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| Molecular Profile | TP53 inact mut |
| Therapy | Osimertinib |
| Indication/Tumor Type | lung non-small cell carcinoma |
| Response Type | not predictive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| TP53 inact mut | lung non-small cell carcinoma | not predictive | Osimertinib | Clinical Study - Cohort | Actionable | In a retrospective analysis, patients with non-small cell lung cancer harboring inactivating TP53 mutations at treatment discontinuation of Tagrisso (osimertinib) had shorter time to treatment discontinuation (5 vs 11.5 months, p=0.0005) compared to patients with wild-type TP53 (PMID: 31839416). | 31839416 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (31839416) | Next-generation sequencing based mutation profiling reveals heterogeneity of clinical response and resistance to osimertinib. | Full reference... |