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| Molecular Profile | AXL pos FLT3 exon 14 ins |
| Therapy | ONO-7475 |
| Indication/Tumor Type | acute myeloid leukemia |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| AXL pos FLT3 exon 14 ins | acute myeloid leukemia | sensitive | ONO-7475 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, ONO-7475 treatment inhibited phosphorylation of Flt3, Erk and S6, induced apoptosis and cell cycle arrest, and reduced viability of acute myeloid leukemia cell lines expressing AXL and harboring FLT3-ITD in culture, and increased median survival in a cell line xenograft model (PMID: 28912176). | 28912176 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (28912176) | Anexelekto/MER tyrosine kinase inhibitor ONO-7475 arrests growth and kills FMS-like tyrosine kinase 3-internal tandem duplication mutant acute myeloid leukemia cells by diverse mechanisms. | Full reference... |