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Molecular Profile AXL pos FLT3 exon 14 ins
Therapy Cytarabine + ONO-7475
Indication/Tumor Type acute myeloid leukemia
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
AXL pos FLT3 exon 14 ins acute myeloid leukemia sensitive Cytarabine + ONO-7475 Preclinical - Cell culture Actionable In a preclinical study, ONO-7475 combined with Cytosar-U (cytarabine) treatment resulted in enhanced reduction in viability and induction of apoptosis in acute myeloid leukemia cell lines expressing AXL and harboring FLT3-ITD in culture (PMID: 28912176). 28912176
PubMed Id Reference Title Details
(28912176) Anexelekto/MER tyrosine kinase inhibitor ONO-7475 arrests growth and kills FMS-like tyrosine kinase 3-internal tandem duplication mutant acute myeloid leukemia cells by diverse mechanisms. Full reference...