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| Molecular Profile | HRAS wild-type |
| Therapy | FTI-277 |
| Indication/Tumor Type | cancer |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| HRAS wild-type | cancer | predicted - sensitive | FTI-277 | Preclinical | Actionable | In a preclinical study, the farnesyltransferase inhibitor FTI-277 sensitized Hras transformed rat fibroblasts to radiation therapy (PMID: 8620483). | 8620483 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (8620483) | The farnesyltransferase inhibitor FTI-277 radiosensitizes H-ras-transformed rat embryo fibroblasts. | Full reference... |