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| Molecular Profile | TSC2 D1598fs TSC2 D1690fs |
| Therapy | Everolimus |
| Indication/Tumor Type | hepatocellular carcinoma |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| TSC2 D1598fs TSC2 D1690fs | hepatocellular carcinoma | predicted - sensitive | Everolimus | Case Reports/Case Series | Actionable | In a clinical study, a hepatocellular carcinoma patient harboring TSC2 D1598fs and TSC2 D1690fs achieved stable disease following treatment with Afinitor (everolimus) (PMID: 30373752). | 30373752 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (30373752) | Prospective Genotyping of Hepatocellular Carcinoma: Clinical Implications of Next-Generation Sequencing for Matching Patients to Targeted and Immune Therapies. | Full reference... |