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Molecular Profile | BRAF V47_D380del BRAF V600E |
Therapy | Vemurafenib |
Indication/Tumor Type | melanoma |
Response Type | resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BRAF V47_D380del BRAF V600E | melanoma | resistant | Vemurafenib | Preclinical - Cell culture | Actionable | In a preclinical study, expression of BRAF V47_D380del in a melanoma cell line harboring BRAF V600E conferred resistance to Zelboraf (vemurafenib) in culture (PMID: 29605720). | 29605720 |
PubMed Id | Reference Title | Details |
---|---|---|
(29605720) | Concomitant BCORL1 and BRAF Mutations in Vemurafenib-Resistant Melanoma Cells. | Full reference... |