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Molecular Profile | IDH1 R132H |
Therapy | Trichostatin A |
Indication/Tumor Type | glioblastoma |
Response Type | resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
IDH1 R132H | glioblastoma | resistant | Trichostatin A | Preclinical - Cell culture | Actionable | In a preclinical study, glioblastoma cells expressing IDH1 R132H were resistant to treatment with Trichostatin (TSA) in culture, demonstrating decreased apoptotic activity and increased cell viability (PMID: 31151327). | 31151327 |
PubMed Id | Reference Title | Details |
---|---|---|
(31151327) | IDH1R132H Causes Resistance to HDAC Inhibitors by Increasing NANOG in Glioblastoma Cells. | Full reference... |