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| Molecular Profile | IDH1 R132H |
| Therapy | Vorinostat |
| Indication/Tumor Type | glioblastoma |
| Response Type | resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| IDH1 R132H | glioblastoma | resistant | Vorinostat | Preclinical - Cell culture | Actionable | In a preclinical study, glioblastoma cells expressing IDH1 R132H were resistant to treatment with Zolinza (vorinostat) in culture, demonstrating increased cell viability (PMID: 31151327). | 31151327 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (31151327) | IDH1R132H Causes Resistance to HDAC Inhibitors by Increasing NANOG in Glioblastoma Cells. | Full reference... |