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Molecular Profile PTEN loss
Therapy MK2206
Indication/Tumor Type osteosarcoma
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PTEN loss osteosarcoma sensitive MK2206 Preclinical - Pdx Actionable In a preclinical study, a patient derived xenograft (PDX) model of osteosarcoma with biallelic loss of PTEN was sensitive to treatment with MK2206, demonstrating reduced tumor growth and increased apoptotic activity (PMID: 30266815). 30266815
PubMed Id Reference Title Details
(30266815) Genome-Informed Targeted Therapy for Osteosarcoma. Full reference...