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Molecular Profile | PIK3CA mutant |
Therapy | Carboxyamidotriazole Orotate |
Indication/Tumor Type | squamous cell carcinoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
PIK3CA mutant | squamous cell carcinoma | sensitive | Carboxyamidotriazole Orotate | Phase I | Actionable | In a Phase I clinical trial, carboxyamidotriazole orotate treatment demonstrated some efficacy in patients with various solid tumors including squamous cell carcinomas (tonsil) with PI3KCA and NRAS mutations (J Clin Oncol 31, 2013 (suppl; abstr 2518)). | detail... |
PubMed Id | Reference Title | Details |
---|---|---|
A phase I study of carboxyamidotriazole orotate (CTO) in of advanced solid tumors. | Full reference... |