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| Authors | Alan Sandler, Matthew Hiram Taylor, Walter John Urba, Antonio Marcilio Padula Omuro, Barry Douglas Anderson, Daniel Hansen, Brenda Fisher, Alisa J Claeys, Amy Greathouse, Sean McLean, Rashida A. Karmali | ||||||||||||
| Title | A phase I study of carboxyamidotriazole orotate (CTO) in of advanced solid tumors. | ||||||||||||
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| URL | http://meetinglibrary.asco.org/content/115114-132 | ||||||||||||
| Abstract Text | J Clin Oncol 31, 2013 (suppl; abstr 2518) | ||||||||||||
| Molecular Profile | Treatment Approach |
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| Gene Name | Source | Synonyms | Protein Domains | Gene Description | Gene Role |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
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| Gene | Variant | Impact | Protein Effect | Variant Description | Associated with drug Resistance |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| PIK3CA mutant | Advanced Solid Tumor | sensitive | Carboxyamidotriazole Orotate | Phase I | Actionable | In a Phase I clinical trial, carboxyamidotriazole orotate treatment demonstrated some efficacy in patients with various solid tumors, including patients harboring PIK3CA mutations (J Clin Oncol 31, 2013 (suppl; abstr 2518)). | detail... |
| PIK3CA mutant | squamous cell carcinoma | sensitive | Carboxyamidotriazole Orotate | Phase I | Actionable | In a Phase I clinical trial, carboxyamidotriazole orotate treatment demonstrated some efficacy in patients with various solid tumors including squamous cell carcinomas (tonsil) with PI3KCA and NRAS mutations (J Clin Oncol 31, 2013 (suppl; abstr 2518)). | detail... |