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Ref Type
PMID
Authors Alan Sandler, Matthew Hiram Taylor, Walter John Urba, Antonio Marcilio Padula Omuro, Barry Douglas Anderson, Daniel Hansen, Brenda Fisher, Alisa J Claeys, Amy Greathouse, Sean McLean, Rashida A. Karmali
Title A phase I study of carboxyamidotriazole orotate (CTO) in of advanced solid tumors.
Journal Vol Issue Date Pages Journal Short Title
31
URL http://meetinglibrary.asco.org/content/115114-132
Abstract Text J Clin Oncol 31, 2013 (suppl; abstr 2518)

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PIK3CA mutant squamous cell carcinoma sensitive Carboxyamidotriazole Orotate Phase I Actionable In a Phase I clinical trial, carboxyamidotriazole orotate treatment demonstrated some efficacy in patients with various solid tumors including squamous cell carcinomas (tonsil) with PI3KCA and NRAS mutations (J Clin Oncol 31, 2013 (suppl; abstr 2518)). detail...
PIK3CA mutant Advanced Solid Tumor sensitive Carboxyamidotriazole Orotate Phase I Actionable In a Phase I clinical trial, carboxyamidotriazole orotate treatment demonstrated some efficacy in patients with various solid tumors, including patients harboring PIK3CA mutations (J Clin Oncol 31, 2013 (suppl; abstr 2518)). detail...