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| Molecular Profile | MSH6 T1219I |
| Therapy | Temozolomide |
| Indication/Tumor Type | glioblastoma |
| Response Type | resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| MSH6 T1219I | glioblastoma | resistant | Temozolomide | Preclinical | Actionable | In a preclinical study, glioblastoma cells harboring a MSH6 T1219I mutation were resistant to Temodar (temozolomide) in cell culture (PMID: 19584161). | 19584161 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (19584161) | MSH6 mutations arise in glioblastomas during temozolomide therapy and mediate temozolomide resistance. | Full reference... |