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| Molecular Profile | NTRK1 positive |
| Therapy | GNF-5837 |
| Indication/Tumor Type | gastrointestinal system cancer |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| NTRK1 positive | gastrointestinal system cancer | sensitive | GNF-5837 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, GNF-5837 prevented proliferation of transformed rat intestinal epithelial cells expressing Ntrk1 in culture and in xenograft mouse models (PMID: 24900443). | 24900443 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (24900443) | Discovery of GNF-5837, a Selective TRK Inhibitor with Efficacy in Rodent Cancer Tumor Models. | Full reference... |