Therapy Detail
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| Therapy Name | GNF-5837 |
| Synonyms | |
| Therapy Description |
GNF-5837 is a small molecule inhibitor of tropomyosin receptor kinases NTRK1 (TRKA), NTRK2 (TRKB), and NTRK3 (TRKC), preventing proliferation of cancer cell models (PMID: 24900443, PMID: 31485624). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| GNF-5837 | Trk Receptor Inhibitor (Pan) 33 | GNF-5837 is a small molecule inhibitor of tropomyosin receptor kinases NTRK1 (TRKA), NTRK2 (TRKB), and NTRK3 (TRKC), preventing proliferation of cancer cell models (PMID: 24900443, PMID: 31485624). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| NTRK1 positive | gastrointestinal system cancer | sensitive | GNF-5837 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, GNF-5837 prevented proliferation of transformed rat intestinal epithelial cells expressing Ntrk1 in culture and in xenograft mouse models (PMID: 24900443). | 24900443 |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
- Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.
| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|
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