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Molecular Profile RAD51C loss
Therapy Olaparib
Indication/Tumor Type stomach cancer
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RAD51C loss stomach cancer sensitive Olaparib Preclinical - Cell line xenograft Actionable In a preclinical study, RAD51C-deficient gastric cancer cells demonstrated increased sensitivity to Lynparza (olaparib) compared to cells over expressing RAD51C, and Lynparza (olaparib) treatment inhibited tumor growth in RAD51C-deficient gastric cancer cell line xenograft models (PMID: 23512992). 23512992
PubMed Id Reference Title Details
(23512992) RAD51C-deficient cancer cells are highly sensitive to the PARP inhibitor olaparib. Full reference...