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| Molecular Profile | ERBB3 positive |
| Therapy | Patritumab |
| Indication/Tumor Type | colorectal cancer |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| ERBB3 positive | colorectal cancer | predicted - sensitive | Patritumab | Preclinical - Cell line xenograft | Actionable | In a preclinical study, Patritumab treatment resulted in reduced Erbb3 (Her3) phosphorylation in Erbb3 (Her3)-positive colorectal cancer cell lines in culture and modest antitumor activity in cell line xenograft models (PMID: 31395690). | 31395690 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (31395690) | U3-1402, a Novel HER3-Targeting Antibody-Drug Conjugate, for the Treatment of Colorectal Cancer. | Full reference... |