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Molecular Profile | BRAF V600E CD274 pos |
Therapy | Dabrafenib |
Indication/Tumor Type | lung adenocarcinoma |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BRAF V600E CD274 pos | lung adenocarcinoma | predicted - sensitive | Dabrafenib | Case Reports/Case Series | Actionable | In a clinical case study, a patient with CD274 (PD-L1)-positive (IHC = 90% of tumor cells) metastatic lung adenocarcinoma harboring BRAF V600E achieved a partial response to treatment with Tafinlar (dabrafenib) and remained stable with improved performance status for 18 months until disease progression, and subsequently achieved a response to Keytruda (pembrolizumab) treatment (PMID: 29142786). | 29142786 |
PubMed Id | Reference Title | Details |
---|---|---|
(29142786) | Extraordinary clinical benefit to sequential treatment with targeted therapy and immunotherapy of a BRAF V600E and PD-L1 positive metastatic lung adenocarcinoma. | Full reference... |