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Molecular Profile | KIT V560_Y578del KIT T670I |
Therapy | Copanlisib |
Indication/Tumor Type | gastrointestinal stromal tumor |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
KIT V560_Y578del KIT T670I | gastrointestinal stromal tumor | sensitive | Copanlisib | Preclinical - Cell line xenograft | Actionable | In a preclinical study, Aliqopa (copanlisib) inhibited cell growth and PI3K signaling in a gastrointestinal stromal tumor cell line harboring KIT V560_Y578del and KIT T670I in culture, and inhibited tumor growth in cell line xenograft models (PMID: 32371592). | 32371592 |
PubMed Id | Reference Title | Details |
---|---|---|
(32371592) | Preclinical Activity of PI3K Inhibitor Copanlisib in Gastrointestinal Stromal Tumor. | Full reference... |