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Molecular Profile | FBXW7 H468R |
Therapy | JQ1 |
Indication/Tumor Type | adult T-cell leukemia/lymphoma |
Response Type | resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FBXW7 H468R | adult T-cell leukemia/lymphoma | resistant | JQ1 | Preclinical - Cell culture | Actionable | In a preclinical study, adult T cell leukemia cells expressing FBXW7 H468R were resistant to treatment with JQ1 in culture (PMID: 32907612). | 32907612 |
PubMed Id | Reference Title | Details |
---|---|---|
(32907612) | Loss of FBXW7-mediated degradation of BRAF elicits resistance to BET inhibitors in adult T cell leukemia cells. | Full reference... |