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| Molecular Profile | ERBB3 positive |
| Therapy | ISU104 |
| Indication/Tumor Type | pancreatic cancer |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| ERBB3 positive | pancreatic cancer | sensitive | ISU104 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, ISU104 treatment inhibited Erbb3 phosphorylation, downstream signaling, and proliferation of pancreatic cancer cells in culture, and inhibited tumor growth in a cell line xenograft model (PMID: 33782100). | 33782100 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (33782100) | A Novel Therapeutic Anti-ErbB3, ISU104 Exhibits Potent Antitumorigenic Activity by Inhibiting Ligand Binding and ErbB3 Heterodimerization. | Full reference... |