Therapy Detail
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| Therapy Name | ISU104 |
| Synonyms | |
| Therapy Description |
ISU104 is a human monoclonal antibody targeting ERBB3 (HER3), potentially inhibits downstream signaling, cell proliferation, and tumor growth (PMID: 33782100). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| ISU104 | ISU-104|ISU 104|Barecetamab | HER3 (ERBB3) Antibody 30 | ISU104 is a human monoclonal antibody targeting ERBB3 (HER3), potentially inhibits downstream signaling, cell proliferation, and tumor growth (PMID: 33782100). |
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| ERBB3 positive | pancreatic cancer | sensitive | ISU104 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, ISU104 treatment inhibited Erbb3 phosphorylation, downstream signaling, and proliferation of pancreatic cancer cells in culture, and inhibited tumor growth in a cell line xenograft model (PMID: 33782100). | 33782100 |
| ERBB3 positive | skin cancer | sensitive | ISU104 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, ISU104 treatment inhibited Erbb3 phosphorylation and downstream signaling in a skin cancer cell line in culture, and inhibited tumor growth in a cell line xenograft model (PMID: 33782100). | 33782100 |
| ERBB3 positive | breast cancer | sensitive | ISU104 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, ISU104 treatment inhibited Erbb3 phosphorylation, downstream signaling, and proliferation in breast cancer cell lines in culture, and inhibited tumor growth in cell line xenograft models (PMID: 33782100). | 33782100 |
| ERBB3 positive | colon cancer | sensitive | ISU104 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, ISU104 treatment inhibited Erbb3 phosphorylation and downstream signaling in a colon cancer cell line in culture, and inhibited tumor growth in a cell line xenograft model (PMID: 33782100). | 33782100 |
| ERBB3 positive | lung non-small cell carcinoma | sensitive | ISU104 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, ISU104 treatment inhibited Erbb3 phosphorylation and downstream signaling in a non-small cell lung cancer cell line in culture, and inhibited tumor growth in a cell line xenograft model (PMID: 33782100). | 33782100 |
| ERBB3 positive | head and neck squamous cell carcinoma | sensitive | ISU104 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, ISU104 treatment inhibited Erbb3 phosphorylation and downstream signaling in head and neck squamous carcinoma cell lines in culture, and resulted in tumor regression in cell line xenograft models (PMID: 33782100). | 33782100 |
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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