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| Molecular Profile | FLT3 I836del |
| Therapy | Cytarabine + Mitoxantrone + Sorafenib |
| Indication/Tumor Type | acute myeloid leukemia |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| FLT3 I836del | acute myeloid leukemia | predicted - sensitive | Cytarabine + Mitoxantrone + Sorafenib | Case Reports/Case Series | Actionable | In a clinical study, combination treatment with Cytosar-U (cytarabine), Novantrone (mitoxantrone), and Nexavar (sorafenib) treatment in an acute myeloid leukemia patient harboring FLT3 I836del led to remission with negative minimal residual disease (PMID: 33563661; NCT02670525). | 33563661 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (33563661) | Matched Targeted Therapy for Pediatric Patients with Relapsed, Refractory, or High-Risk Leukemias: A Report from the LEAP Consortium. | Full reference... |