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Molecular Profile | NRAS G13D |
Therapy | Copanlisib + ERAS-007 |
Indication/Tumor Type | mantle cell lymphoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
NRAS G13D | mantle cell lymphoma | sensitive | Copanlisib + ERAS-007 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, the combination of ERAS-007 (ASN007) and Aliqopa (copanlisib) inhibited tumor growth in a cell line xenograft model of mantle cell lymphoma harboring NRAS G13D, and demonstrated improved efficacy over either agent alone (PMID: 34337566). | 34337566 |
PubMed Id | Reference Title | Details |
---|---|---|
(34337566) | ASN007 is a selective ERK1/2 inhibitor with preferential activity against RAS-and RAF-mutant tumors. | Full reference... |