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| Molecular Profile | FGFR3 rearrange FGFR3 F384L |
| Therapy | Futibatinib |
| Indication/Tumor Type | multiple myeloma |
| Response Type | no benefit |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| FGFR3 rearrange FGFR3 F384L | multiple myeloma | no benefit | Futibatinib | Preclinical - Cell culture | Actionable | In a preclinical study, a multiple myeloma cell line harboring an FGFR3 rearrangement and FGFR3 F384L was not sensitive to treatment with Lytgobi (futibatinib) in culture (PMID: 32973082). | 32973082 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (32973082) | Futibatinib Is a Novel Irreversible FGFR 1-4 Inhibitor That Shows Selective Antitumor Activity against FGFR-Deregulated Tumors. | Full reference... |