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ID DOID:9538
Name multiple myeloma
Definition A myeloid neoplasm that is located_in the plasma cells in bone marrow.
Source DiseaseOntology.org
Alt Ids
Path disease disease of cellular proliferation cancer organ system cancer hematologic cancer bone marrow cancer myeloid neoplasm multiple myeloma

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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
FGFR3 over exp Vofatamab multiple myeloma sensitive detail...
FGFR3 Y373C FGFR3 over exp AZ8010 multiple myeloma sensitive detail...
FGFR3 K650E FGFR3 over exp HRAS K117E PD173074 multiple myeloma sensitive detail...
FGFR3 Y373C FGFR3 over exp PD173074 multiple myeloma sensitive detail...
FGFR3 G384D FGFR3 over exp PD173074 multiple myeloma decreased response detail...
FGFR3 G384D FGFR3 over exp Fexagratinib multiple myeloma decreased response detail...
FGFR3 G384D FGFR3 over exp AZ8010 multiple myeloma decreased response detail...
NRAS mutant Trametinib multiple myeloma sensitive detail...
BRAF mutant Trametinib multiple myeloma sensitive detail...
FGFR3 Y373C E7090 multiple myeloma sensitive detail...
TP53 wild-type KRT-232 multiple myeloma predicted - sensitive detail...
FGFR3 rearrange FGFR3 K650E Futibatinib multiple myeloma predicted - sensitive detail...
FGFR3 rearrange FGFR3 Y373C Futibatinib multiple myeloma sensitive detail...
FGFR3 rearrange FGFR3 F384L Futibatinib multiple myeloma no benefit detail...
FGFR3 rearrange NRAS act mut Futibatinib multiple myeloma no benefit detail...
FGFR3 fusion FGFR3 mut 3D185 multiple myeloma sensitive detail...
NRAS act mut BMF-219 multiple myeloma predicted - sensitive detail...
BRAF V600E Binimetinib + Encorafenib multiple myeloma sensitive detail...
NRAS G12D Trametinib multiple myeloma sensitive detail...
NRAS G12D MRTX-1133 multiple myeloma no benefit detail...
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT00602693 Phase I Sirolimus Allopurinol + Cyclophosphamide + Fludarabine T-Regulatory Cell Infusion Post Umbilical Cord Blood Transplant in Patients With Advanced Hematologic Cancer Completed USA 0
NCT00720785 Phase I Bortezomib Natural Killer Cells and Bortezomib to Treat Cancer Completed USA 0
NCT00734877 Phase III Cisplatin + Cyclophosphamide + Doxorubicin + Etoposide Bortezomib + Dexamethasone + Melphalan + Thalidomide UARK 2008-01, Total Therapy 4 - A Phase III Trial for Low Risk Myeloma Active, not recruiting USA 0
NCT00881920 Phase I CAR.k.28 cells Cyclophosphamide + Fludarabine Kappa-CD28 T Lymphocytes, Chronic Lymphocytic Leukemia, B-cell Lymphoma or Multiple Myeloma, CHARKALL (CHARKALL) Recruiting USA 0
NCT00903968 Phase Ib/II Bortezomib + Plerixafor Combination Plerixafor (AMD3100)and Bortezomib in Relapsed or Relapsed/Refractory Multiple Myeloma Completed USA 0
NCT00918333 Phase Ib/II Everolimus + Panobinostat Panobinostat and Everolimus in Treating Patients With Recurrent Multiple Myeloma, Non-Hodgkin Lymphoma, or Hodgkin Lymphoma Completed USA 0
NCT01028716 Phase II Filgrastim + Mycophenolate mofetil + Tacrolimus Cyclophosphamide + Fludarabine Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies Terminated USA 0
NCT01084252 Phase Ib/II Isatuximab Dexamethasone + Isatuximab Phase 1/2 Dose Escalation and Efficacy Study of Anti-CD38 Monoclonal Antibody in Patients With Selected CD38+ Hematological Malignancies Completed USA | TUR | ITA | ISR | GRC | GBR | FRA | FIN | ESP | BRA | BEL | ARG 5
NCT01146834 Phase III Bortezomib + Filgrastim Bortezomib + Cyclophosphamide + Filgrastim Bortezomib + Cyclophosphamide Trial of Three Stem Cell Mobilization Regimens for Multiple Myeloma Completed USA 0
NCT01163357 Phase I Sirolimus Bortezomib + Fludarabine + Melphalan Bortezomib, Total Marrow Irradiation, Fludarabine Phosphate, and Melphalan in Treating Patients Undergoing Donor Peripheral Blood Stem Cell Transplant For High-Risk Stage I or II Multiple Myeloma Active, not recruiting USA 0
NCT01177397 Phase Ib/II Onatasertib Study to Assess Safety, Pharmacokinetics, and Efficacy of Oral CC-223 for Patients With Advanced Solid Tumors, Non-Hodgkin Lymphoma or Multiple Myeloma Completed USA | GBR | FRA | ESP 0
NCT01177683 Phase Ib/II Bendamustine + Bortezomib + Pegylated liposomal doxorubicin Filgrastim Bendamustine in Combination With Bortezomib and Pegylated Liposomal Doxorubicin for Multiple Myeloma Terminated USA 0
NCT01208662 Phase III Bortezomib + Dexamethasone + Lenalidomide Randomized Trial of Lenalidomide, Bortezomib, Dexamethasone vs High-Dose Treatment With SCT in MM Patients up to Age 65 (DFCI 10-106) Active, not recruiting USA 0
NCT01239368 Phase I Th1/Tc1 Immunotherapy Following Stem Cell Transplantation in Multiple Myeloma Terminated USA 0
NCT01241708 Phase III Bortezomib Tandem Auto Stem Cell Transplant With Melphalan Followed by Melphalan and Bortezomib in Patients With Multiple Myeloma ((Mel/MelVel)) Completed USA 0
NCT01251575 Phase II Fludarabine Cyclosporine + Mycophenolate mofetil + Sirolimus Sirolimus, Cyclosporine, and Mycophenolate Mofetil In Preventing Graft-Versus-Host Disease in Treating Patients With Hematologic Malignancies Undergoing Donor Peripheral Blood Stem Cell Transplant Completed USA | DNK 0
NCT01287546 Phase I Emibetuzumab + Erlotinib Emibetuzumab + Trametinib Emibetuzumab A Study of LY2875358 in Participants With Advanced Cancer Completed USA 0
NCT01301807 Phase I Carfilzomib + Panobinostat Carfilzomib Plus Panobinostat in Relapsed/Refractory Multiple Myeloma (MM) Completed USA 0
NCT01313897 Phase II Bortezomib UARK 2010-35, A Study of Expanded Natural Killer Cell Therapy for Multiple Myeloma (NK2010-35) Completed USA 0
NCT01323751 Phase Ib/II Bortezomib + Dexamethasone Ricolinostat Study of ACY-1215 Alone and in Combination With Bortezomib and Dexamethasone in Multiple Myeloma Completed USA 0
NCT01326702 Phase Ib/II Veliparib Rituximab Bendamustine Veliparib, Bendamustine Hydrochloride, and Rituximab in Treating Patients With Relapsed or Refractory Lymphoma, Multiple Myeloma, or Solid Tumors Completed USA 0
NCT01345019 Phase III Denosumab Zoledronic acid Denosumab Compared to Zoledronic Acid in the Treatment of Bone Disease in Subjects With Multiple Myeloma Completed USA | TUR | SVK | POL | NZL | LTU | ITA | IRL | HUN | GRC | GBR | FRA | ESP | DEU | CZE | CHE | CAN | BGR | AUT | AUS 9
NCT01353625 Phase I CC-115 Study to Assess Safety and Tolerability of Oral CC-115 for Patients With Advanced Solid Tumors, and Hematologic Malignancies. Completed USA | FRA | ESP | DEU 0
NCT01421524 Phase I CC-122 Study of CC-122 to Evaluate the Safety, Tolerability, and Effectiveness for Patients With Advanced Solid Tumors, Non-Hodgkin's Lymphoma, or Multiple Myeloma Completed USA | ITA | FRA | ESP | BEL 0
NCT01428492 Phase I Afuresertib Bortezomib Dexamethasone Ph 1b Study to Evaluate GSK2110183 in Combination With Bortezomib and Dexamethasone in Subjects With Multiple Myeloma Completed USA | IRL | CAN | AUS 1
NCT01440582 Phase I Bortezomib + Dexamethasone + Lenalidomide + Panobinostat Combination Therapy of Lenalidomide/Bortezomib/Dexamethasone and Panobinostat in Transplant Eligible New Diagnosed Multiple Myeloma (MM) Patients Completed USA 0
NCT01453088 Phase II Melphalan Bortezomib Auto Transplant High Dose Melphalan vs High Dose Melphalan+Bortezomib in Pts With Multiple Myeloma Age 65 Years or Older Terminated USA 0
NCT01453101 Phase II Fludarabine + Melphalan Bortezomib Allogeneic Hematopoietic Stem Cell Transplantation for Multiple Myeloma Completed USA 0
NCT01456689 Phase I Midazolam LGH447 A Study of Oral LGH447 in Patients With Relapsed and/or Refractory Multiple Myeloma Completed USA | ESP | DEU 1
NCT01470131 Phase III Masitinib Bortezomib + Dexamethasone A Phase 3 Study to Evaluate Efficacy and Safety of Masitinib in Patients With Relapse or Refractory Multiple Myeloma Terminated USA | FRA 0
NCT01522872 Phase Ib/II Evofosfamide Bortezomib Open-label Study of TH-302 and Dexamethasone With or Without Bortezomib in Subjects With Relapsed/Refractory Multiple Myeloma Unknown status USA 0
NCT01524978 Phase II Vemurafenib Cetuximab A Study of Zelboraf (Vemurafenib) in Patients With BRAF V600 Mutation-Positive Cancers Completed USA | GBR | FRA | ESP | DEU 1
NCT01526096 Phase I Basiliximab Filgrastim Plerixafor Melphalan Stem Cell Transplantation for Patients With Multiple Myeloma Active, not recruiting USA 0
NCT01547806 Phase II Filgrastim Plerixafor Collection of Transplant Stem Cells for Plasma Cell Myeloma Completed USA 0
NCT01582295 Phase I Cabozantinib XL184 For Relapsed/Refractory Multiple Myeloma (MM) With Bone Disease Completed USA 0
NCT01587703 Phase I Molibresib A Study to Investigate the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of GSK525762 in Subjects With NUT Midline Carcinoma (NMC) and Other Cancers Completed USA | NLD | GBR | FRA | ESP | AUS 1
NCT01592370 Phase Ib/II Nivolumab Daratumumab + Nivolumab Daratumumab Ipilimumab + Nivolumab Daratumumab + Dexamethasone + Nivolumab + Pomalidomide Lirilumab + Nivolumab An Investigational Immuno-Therapy Study to Determine the Safety and Effectiveness of Nivolumab and Daratumumab in Patients With Multiple Myeloma Completed USA | POL | ITA | GRC | FRA | BEL 0
NCT01609816 Phase Ib/II Dasatinib Dasatinib in Treating Patients With Multiple Myeloma, Non-Hodgkin, or Hodgkin Lymphoma Previously Treated With Autologous Stem Cell Transplant Terminated USA 0
NCT01665794 Phase Ib/II Carfilzomib + Dexamethasone + Pomalidomide Carfilzomib + Daratumumab + Dexamethasone + Pomalidomide Carfilzomib, Pomalidomide, and Dexamethasone in Treating Patients With Relapsed or Refractory Multiple Myeloma Active, not recruiting USA | CAN 0
NCT01668719 Phase Ib/II Elotuzumab Bortezomib + Dexamethasone + Lenalidomide S1211, Bortezomib, Dexamethasone, and Lenalidomide With or Without Elotuzumab in Treating Patients With Newly Diagnosed High-Risk Multiple Myeloma Active, not recruiting USA 0
NCT01672736 Phase Ib/II Bortezomib + Dexamethasone + Linsitinib A Trial of ASP7487 (OSI-906) in Combination With Bortezomib for the Treatment of Relapsed Multiple Myeloma Terminated USA | CAN 0
NCT01689987 Phase I Cyclophosphamide + Dexamethasone + Hydroxychloroquine + Sirolimus Hydroxychloroquine, Cyclophosphamide, Dexamethasone, and Sirolimus in Treating Patients With Relapsed or Refractory Multiple Myeloma Completed USA 0
NCT01695330 Phase II Bortezomib Subcutaneous (SC) Bortezomib-Regimens for Patients With RR MM Failing Prior IV Bortezomib-Containing Regimens Terminated USA 0
NCT01711528 Phase I Bortezomib + Dexamethasone + Dinaciclib Dinaciclib, Bortezomib, and Dexamethasone in Treating Patients With Relapsed Multiple Myeloma Completed USA 0
NCT01723020 Phase I KRT-232 A Phase 1 Study Evaluating AMG 232 in Advanced Solid Tumors or Multiple Myeloma Completed USA | NLD | FRA 0
NCT01729091 Phase Ib/II Dexamethasone Elotuzumab Filgrastim Melphalan Lenalidomide Study of Umbilical Cord Blood-derived Natural Killer Cells in Conjunction With High Dose Chemotherapy and Autologous Stem Cell Transplant for Patients With Multiple Myeloma Completed USA 0
NCT01729338 Phase II Bortezomib + Cyclophosphamide + Lenalidomide Velcade + Cyclophosphamide in Newly Diagnosed Multiple Myeloma Terminated USA 0
NCT01734928 Phase III Pomalidomide Bortezomib + Dexamethasone Safety and Efficacy of Pomalidomide, Bortezomib and Low-dose Dexamethasone in Subjects With Relapsed or Refractory Multiple Myeloma Completed USA | TUR | SWE | POL | NOR | NLD | ITA | ISR | IRL | GRC | GBR | FRA | FIN | ESP | DNK | DEU | CAN | AUT 4
NCT01794507 Phase I Bortezomib + Dexamethasone + Venetoclax A Study Evaluating ABT-199 in Multiple Myeloma Subjects Who Are Receiving Bortezomib and Dexamethasone as Standard Therapy Completed USA | FRA | AUS 0
NCT01794520 Phase I Venetoclax Study Evaluating ABT-199 in Subjects With Relapsed or Refractory Multiple Myeloma Completed USA | NOR | FRA | BEL 0
NCT01822509 Phase I Ipilimumab + Nivolumab Ipilimumab or Nivolumab in Treating Patients With Relapsed Hematologic Malignancies After Donor Stem Cell Transplant Completed USA 0
NCT01827137 Phase I WT1 vaccine Lenalidomide Sargramostim WT1 Analog Peptide Vaccine in Patients With Multiple Myeloma Following Autologous Stem Cell Transplantation Completed USA 0
NCT01829971 Phase I MRX34 A Multicenter Phase I Study of MRX34, MicroRNA miR-RX34 Liposomal Injection Terminated USA 1
NCT01849783 Phase II Bortezomib + Dexamethasone + Melphalan + Thalidomide Aldoxorubicin + Cisplatin + Cyclophosphamide + Dexamethasone + Etoposide Autologous Stem Cell Transplant Followed By Maintenance Therapy in Treating Elderly Patients With Multiple Myeloma Completed USA 0
NCT01863550 Phase III Dexamethasone Lenalidomide Carfilzomib Bortezomib Bortezomib or Carfilzomib With Lenalidomide and Dexamethasone in Treating Patients With Newly Diagnosed Multiple Myeloma Active, not recruiting USA 1
NCT01866293 Phase Ib/II Cabozantinib Cabozantinib (XL184) in Patients With Relapsed or Refractory Myeloma Completed USA 0
NCT01889420 Phase I Dexamethasone + Everolimus + Pomalidomide Phase I Trial of Everolimus, Pomalidomide and Dexamethasone Patients With Relapsed/Refractory Multiple Myeloma Terminated USA 0
NCT01919086 Phase II Lenalidomide Bortezomib + Dexamethasone Response Adapted Therapy With Bortezomib/Dexamethasone Followed by Addition of Lenalidomide in Non Responders as Initial Treatment for Patients With Multiple Myeloma Completed USA 0
NCT01947140 Phase Ib/II Pralatrexate + Romidepsin Pralatrexate + Romidepsin in Relapsed/Refractory Lymphoid Malignancies (PDX+Romi) Completed USA 0
NCT01953692 Phase I Pembrolizumab A Trial of Pembrolizumab (MK-3475) in Participants With Blood Cancers (MK-3475-013)(KEYNOTE-013) Completed 0
NCT01954784 Phase I Bortezomib + Cyclosporine + Mycophenolate mofetil Lenalidomide Lenalidomide After Donor Stem Cell Transplant and Bortezomib in Treating Patients With High Risk Multiple Myeloma Terminated USA 0
NCT01955434 Phase II Cyclophosphamide + LCL161 SMAC Mimetic LCL161 Alone or With Cyclophosphamide in Treating Patients With Relapsed or Refractory Multiple Myeloma Completed USA 0
NCT01962792 Phase Ib/II Carfilzomib + Ibrutinib Dexamethasone Study of the Bruton's Tyrosine Kinase Inhibitor in Combination With Carfilzomib (Kyprolis), in Subjects With Relapsed or Relapsed and Refractory Multiple Myeloma Completed USA | CAN 0
NCT01965353 Phase I Bortezomib + Dexamethasone + Lenalidomide + Panobinostat A Phase I Study Of Panobinostat/Lenalidomide/Bortezomib/Dex for Relapsed And Relapsed/Refractory Multiple Myeloma Completed USA 0
NCT01989598 Phase II Trametinib + Uprosertib Trametinib and Akt Inhibitor GSK2141795 in Treating Patients With Relapsed or Refractory Multiple Myeloma Completed CAN 0
NCT01995708 Phase I CT7/MAGE-A3/WT1 mRNA-electroporated LCs CT7, MAGE-A3, and WT1 mRNA-electroporated Autologous Langerhans-type Dendritic Cells as Consolidation for Multiple Myeloma Patients Undergoing Autologous Stem Cell Transplantation Completed USA 0
NCT01997840 Phase Ib/II Dexamethasone + Pomalidomide + Ricolinostat ACY-1215 (Ricolinostat) in Combination With Pomalidomide and Low-dose Dex in Relapsed-and-Refractory Multiple Myeloma Terminated USA 0
NCT01998971 Phase I Pomalidomide Bortezomib + Dexamethasone Melphalan Thalidomide Lenalidomide Prednisone Daratumumab Carfilzomib Diphenhydramine Montelukast A Study of JNJ-54767414 (HuMax CD38) (Anti-CD38 Monoclonal Antibody) in Combination With Backbone Treatments for the Treatment of Patients With Multiple Myeloma Completed USA | FRA | ESP 0
NCT02030483 Phase I Palbociclib Dexamethasone Lenalidomide Palbociclib in Combination With Lenalidomide and Dexamethasone for Multiple Myeloma Terminated USA 0
NCT02034110 Phase II Dabrafenib + Trametinib Efficacy and Safety of the Combination Therapy of Dabrafenib and Trametinib in Subjects With BRAF V600E- Mutated Rare Cancers Completed USA | SWE | NOR | NLD | ITA | FRA | ESP | DNK | DEU | CAN | BEL | AUT 2
NCT02036502 Phase I Dexamethasone Lenalidomide + Pembrolizumab A Study of Pembrolizumab (MK-3475) in Combination With Lenalidomide and Dexamethasone in Participants With Multiple Myeloma (MK-3475-023/KEYNOTE-023) Terminated 0
NCT02057640 Phase Ib/II Dexamethasone + Ixazomib + Panobinostat MLN9708 (Ixazomib) in Combination With Panobinostat and Dexamethasone in Multiple Myeloma Completed USA 0
NCT02061761 Phase Ib/II Nivolumab + Relatlimab Relatlimab Safety Study of Anti-LAG-3 in Relapsed or Refractory Hematologic Malignancies Completed USA | CAN 0
NCT02077959 Phase Ib/II Lenalidomide + Pidilizumab Lenalidomide and Pidilizumab in Treating Patients With Relapsed or Refractory Multiple Myeloma Terminated USA 0
NCT02086552 Phase II Lenalidomide + Sonidegib Sonidegib and Lenalidomide After Stem Cell Transplant in Treating Patients With Multiple Myeloma Completed USA 0
NCT02098109 Phase II Plerixafor Filgrastim Non-inferiority Study of XM02 Filgrastim (Granix) and Filgrastim (Neupogen) in Combination With Plerixafor for Autologous Stem Cell Mobilization in Patients With Multiple Myeloma or Non-Hodgkin Lymphoma Completed USA 0
NCT02099539 Phase Ib/II Nogapendekin alfa inbakicept A Study of ALT-803 in Patients With Relapsed or Refractory Multiple Myeloma Terminated USA 0
NCT02101944 Phase I Carfilzomib + Dexamethasone + Pelareorep Viral Protein Production After Dexamethasone, Wild-Type Reovirus, and Carfilzomib in Treating Patients With Multiple Myeloma Completed USA 0
NCT02104427 Phase II Burixafor Filgrastim PD and Safety of TG-0054 Combined With G-CSF in Multiple Myeloma, Non-Hodgkin Lymphoma and Hodgkin Disease Patients Completed USA 0
NCT02110563 Phase I DCR-MYC Phase I, Multicenter, Dose Escalation Study of DCR-MYC in Patients With Solid Tumors, Multiple Myeloma, or Lymphoma Terminated USA 0
NCT02136134 Phase III Daratumumab Bortezomib + Dexamethasone Addition of Daratumumab to Combination of Bortezomib and Dexamethasone in Participants With Relapsed or Refractory Multiple Myeloma Completed USA | TUR | SWE | POL | NLD | HUN | ESP | DEU | CZE | BRA | AUS 4
NCT02140840 Phase II Trametinib A Phase II Open-Label, Multiple-Dose, Single Agent Study to Evaluate the Overall Response Rate of Orally Administered Trametinib Withdrawn USA 0
NCT02144038 Phase Ib/II Alpelisib + LGH447 LGH447 Study of the Safety and Effectiveness of LGH447 and BYL719 in Patients With Relapsed and Refractory Multiple Myeloma Completed USA | ITA | DEU | AUS 1
NCT02157636 Phase I CPI-0610 A Phase 1 Study Evaluating CPI-0610 in Patients With Previously Treated Multiple Myeloma Completed 0
NCT02159365 Phase II Dexamethasone + Elotuzumab + Lenalidomide Study of Safety of Elotuzumab Administered Over Approximately 60 Minutes in Combination With Lenalidomide and Dexamethasone for Newly Diagnosed or Relapsed/Refractory Multiple Myeloma Patients Completed USA 0
NCT02186834 Phase Ib/II Dexamethasone + Pegylated liposomal doxorubicin + Selinexor Selinexor (KPT-330) and Pegylated Liposomal Doxorubicin For Relapsed and Refractory Multiple Myeloma Completed USA 0
NCT02188368 Phase II Bortezomib + Carfilzomib + Clarithromycin Pegylated liposomal doxorubicin + Pomalidomide Pomalidomide Pomalidomide for Lenalidomide for Failures Terminated USA 0
NCT02189343 Phase I Dexamethasone + Pomalidomide + Ricolinostat Phase 1b Study Evaluating ACY-1215 (Ricolinostat) in Combination With Pomalidomide and Dexamethasone in Relapsed-and-Refractory Multiple Myeloma Completed USA 0
NCT02192775 Phase II MV-NIS UARK 2014-21 A Phase II Trial of Oncolytic Virotherapy by Systemic Administration of Edmonston Strain of Measles Virus Completed USA 0
NCT02195479 Phase III Bortezomib Daratumumab Melphalan A Study of Combination of Daratumumanb and Velcade (Bortezomib) Melphalan-Prednisone (DVMP) Compared to Velcade Melphalan-Prednisone (VMP) in Participants With Previously Untreated Multiple Myeloma Completed USA | TUR | ROU | POL | HUN | HRV | GRC | GBR | ESP | DEU | CZE | BRA | BGR | BEL | AUS | ARG 8
NCT02199665 Phase I Carfilzomib + Dexamethasone + Selinexor Selinexor, Carfilzomib, and Dexamethasone in Treating Patients With Relapsed or Refractory Multiple Myeloma Recruiting USA 0
NCT02204553 Phase I Bortezomib + Dexamethasone + Panobinostat Expanded Treatment Prot of Panobinostat in Combo w/ Bortez and Dex in Pts w/ Relapsed and/or Refractory Multiple Myeloma No longer available USA 0
NCT02211014 Phase I Acalabrutinib Dexamethasone An Open-Label, Phase 1b Study of ACP-196 With and Without Dexamethasone in Subjects With Multiple Myeloma Completed USA | GBR 0
NCT02220608 Phase I Bortezomib + Filgrastim Phase I Study of Bortezomib With G-CSF for Stem Cell Mobilization in Patients With Multiple Myeloma Completed USA 0
NCT02223598 Phase I CB-5083 CB-5083 + Dexamethasone A Phase 1 Study Evaluating CB-5083 in Subjects With Lymphoid Hematological Malignancies (CLC-102) Terminated USA | CAN 0
NCT02235740 Phase I Carfilzomib Afuresertib + Carfilzomib A Study Conducted in Subjects With Relapsed/Refractory Multiple Myeloma (MM); to Determine Dose of Afuresertib in Combination With Carfilzomib (Part 1) and to Investigate the Safety, Pharmacokinetic and Clinical Activity of the Combination Compared With Carfilzomib Alone (Part 2) Terminated USA 0
NCT02252263 Phase I Urelumab Lirilumab Elotuzumab A Phase I Open Label Study of the Safety and Tolerability of Elotuzumab (BMS-901608) Administered in Combination With Either Lirilumab (BMS-986015) or Urelumab (BMS-663513) in Subjects With Multiple Myeloma Completed USA | ESP 0
NCT02254551 Phase II Bortezomib + Sonidegib Safety/Efficacy Study of LDE225 (Sonidegib) Plus Bortezomib in Patients With Relapsed or Relapsed/Refractory Multiple Myeloma Terminated USA 0
NCT02283775 Phase I Dexamethasone + Isatuximab + Pomalidomide SAR650984, Pomalidomide and Dexamethasone in Combination in RRMM Patients (PomdeSAR) Completed USA 0
NCT02289222 Phase Ib/II Dexamethasone + Pembrolizumab + Pomalidomide Anti-PD-1 (MK-3475) and IMiD (Pomalidomide) Combination Immunotherapy in Relapsed/Refractory Multiple Myeloma Terminated USA 0
NCT02291848 Phase I MultiTAA-specific T cells Tumor-Associated Antigen-Specific Cytotoxic T-Lymphocytes for Multiple Myeloma (TACTAM) Recruiting USA 0
NCT02308280 Phase II Bortezomib Nonmyeloablative Allogeneic Stem Cell Transplant Followed by Bortezomib in High-risk Multiple Myeloma Patients Completed CAN 0
NCT02328014 Phase Ib/II ACP-319 Acalabrutinib ACP-196 in Combination With ACP-319, for Treatment of B-Cell Malignancies Active, not recruiting USA 0
NCT02331368 Phase II Lenalidomide Melphalan Pembrolizumab Phase 2 Multi-center Study of Anti-PD-1 During Lymphopenic State After HDT/ASCT for Multiple Myeloma Completed USA 0
NCT02332850 Phase I Carfilzomib + Isatuximab SAR650984 in Combination With Carfilzomib for Treatment of Relapsed or Refractory Multiple Myeloma Active, not recruiting USA | CAN 0
NCT02334865 Phase I Lenalidomide + Montanide ISA 51 + Sargramostim + SurVaxM SVN53-67/M57-KLH Peptide Vaccine in Treating Patients With Newly Diagnosed Multiple Myeloma Receiving Lenalidomide Maintenance Therapy Active, not recruiting USA 0
NCT02336815 Phase II Dexamethasone + Selinexor Phase 2b Open-Label Single-Arm Selinexor (KPT-330) + Low-Dose Dexamethasone in Patients w/ Multiple Myeloma Quad-refractory to Previous Therapies Completed USA | GRC | FRA | DEU | BEL | AUT 0
NCT02343042 Phase Ib/II Bortezomib Dexamethasone + Selinexor Pomalidomide Phase 1b/2 Study of Selinexor (KPT-330) in Combination w/ Backbone Treatments for Resistant/Refractory Multiple Myeloma Recruiting USA | CAN 0
NCT02356159 Phase Ib/II Cytarabine + Fludarabine Palifermin Prednisone Filgrastim Methotrexate + Sirolimus + Tacrolimus Doxorubicin + Etoposide + Fludarabine + Vincristine Sulfate Cyclophosphamide + Fludarabine Rituximab Study of Palifermin (Kepivance) in Persons Undergoing Unrelated Donor Allogeneic Hematopoietic Cell Transplantation Active, not recruiting USA 0
NCT02367196 Phase I CC-90002 + Rituximab CC-90002 A Phase 1, Dose Finding Study of CC-90002 in Subjects With Advanced Solid and Hematologic Cancers Completed USA | ESP 0
NCT02368301 Phase I Dexamethasone + Elotuzumab + Lenalidomide Expanded Access Treatment Protocol CA204-143 No longer available 0
NCT02372240 Phase Ib/II Dexamethasone + VLX1570 A Study of VLX1570 and Dexamethasone in Myeloma Patients Terminated USA 0
NCT02375555 Phase II Elotuzumab Bortezomib + Dexamethasone + Lenalidomide Study of Bortezomib,Lenalidomide,Dexamethasone & Elotuzumab in Newly Diagnosed MM Completed USA 0
NCT02391480 Phase I Mivebresib A Study Evaluating the Safety and Pharmacokinetics of ABBV-075 in Subjects With Cancer Completed USA 0
NCT02393248 Phase Ib/II Cisplatin + Gemcitabine + Pemigatinib Docetaxel + Pemigatinib Pemigatinib + Retifanlimab Pemigatinib + Trastuzumab Epacadostat + Pembrolizumab Open-Label, Dose-Escalation Study of Pemigatinib in Subjects With Advanced Malignancies - (FIGHT-101) Terminated USA | DNK 0
NCT02400242 Phase I Citarinostat Dexamethasone Pomalidomide Study of ACY-241 Alone and in Combination With Pomalidomide and Dexamethasone in Multiple Myeloma Terminated USA | GRC | FRA | ESP | DEU 0
NCT02401295 Phase I Celecoxib + Itraconazole + Tretinoin ATRA, Celecoxib, and Itraconazole as Maintenance Completed USA 0
NCT02407509 Phase I RO5126766 Everolimus + RO5126766 Phase I Trial of VS-6766 Alone and in Combination With Everolimus (RAF/MEK) Recruiting GBR 0
NCT02426723 Phase I CWP232291 Dexamethasone + Lenalidomide Clinical Study of CWP232291 in Relapsed or Refractory Myeloma Patients Completed USA 1
NCT02431208 Phase I Lenalidomide Atezolizumab A Study of Atezolizumab (Anti-Programmed Death Ligand 1 [PD-L1] Antibody) Administered With or Without Lenalidomide in Participants With Multiple Myeloma (MM) Completed USA 0
NCT02440464 Phase II Methotrexate + Tacrolimus Ixazomib Fludarabine + Melphalan Bortezomib Allogeneic Hematopoietic Stem Cell Transplantation With Ixazomib for High Risk Multiple Myeloma (BMT CTN 1302) Completed USA 0
NCT02441686 Phase II Bortezomib + Dexamethasone + Lenalidomide Phase II Study of Efficacy and Safety of Lenalidomide, Subcutaneous Bortezomib and Dexamethasone Therapy for Newly Diagnosed Multiple Myeloma Active, not recruiting USA 0
NCT02465060 Phase II Nivolumab + Relatlimab Dabrafenib + Trametinib Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial) Active, not recruiting USA 2
NCT02477878 Phase I BPX-601 Rimiducid Study of Gene Modified Donor T Cell Infusion in Patients With Recurrent Disease After Allogeneic Transplant Active, not recruiting USA 0
NCT02504359 Phase I Ixazomib Carmustine + Cytarabine + Etoposide + Melphalan Methotrexate + Tacrolimus Combination Chemotherapy and Donor Stem Cell Transplant Followed by Ixazomib Citrate Maintenance Therapy in Treating Patients With Relapsed High-Risk Multiple Myeloma Completed USA 0
NCT02514382 Phase I Bortezomib + Dexamethasone + Pelareorep Wild-Type Reovirus, Bortezomib, and Dexamethasone in Treating Patients With Relapsed or Refractory Multiple Myeloma Completed USA 0
NCT02514668 Phase I Isatuximab A Study to Evaluate the Safety, Pharmacokinetics, and Efficacy of Isatuximab in Patients With Multiple Myeloma Completed USA | FRA | CZE 0
NCT02519452 Phase I Daratumumab + rHuPH20 A Study of Daratumumab With the Addition of Recombinant Human Hyaluronidase (rHuPH20) for the Treatment of Participants With Relapsed or Refractory Multiple Myeloma Completed USA | SWE | NLD | FRA | ESP | DNK 0
NCT02548962 Phase Ib/II Ibrutinib Dexamethasone + Pomalidomide Study of Ibrutinib in Combination With Pomalidomide and Dexamethasone in Subjects With Relapsed/Refractory Multiple Myeloma Terminated USA | GRC | ESP | DEU | CZE | AUS 0
NCT02568943 Phase I Bortezomib + Dexamethasone + Panobinostat An Expanded Treatment Protocol of Panobinostat in Combination Therapy for Relapsed, and Relapsed and Refractory Multiple Myeloma No longer available SWE | NOR | DEU | CAN | AUT 1
NCT02569320 Phase I Dexamethasone + Pomalidomide + REC-2282 HDAC Inhibitor AR-42 and Pomalidomide in Treating Patients With Relapsed Multiple Myeloma Completed USA 0
NCT02576496 Phase I Tinostamustine Study of EDO-S101, A First-in-Class Alkylating HDACi Fusion Molecule, in Relapsed/Refractory Hematologic Malignancies Completed USA | NLD | ITA | FRA | ESP | DEU | CHE 0
NCT02576977 Phase III Pomalidomide Pembrolizumab Dexamethasone Study of Pomalidomide and Low Dose Dexamethasone With or Without Pembrolizumab (MK-3475) in Refractory or Relapsed and Refractory Multiple Myeloma (rrMM) (MK-3475-183/KEYNOTE-183) Terminated 0
NCT02579824 Phase I Milademetan DS-3032b for Relapsed and/or Refractory (RR) Myeloma Terminated USA 0
NCT02579863 Phase III Pembrolizumab Dexamethasone Lenalidomide Study of Lenalidomide and Dexamethasone With or Without Pembrolizumab (MK-3475) in Participants With Newly Diagnosed Treatment Naive Multiple Myeloma (MK-3475-185/KEYNOTE-185) Terminated 0
NCT02603887 Phase I Pembrolizumab Pembrolizumab for Smoldering Multiple Myeloma (SMM) Active, not recruiting USA 0
NCT02605356 Phase Ib/II Radium Ra 223 dichloride Bortezomib Dexamethasone Phase 1b/2 Study Testing Radium-223 Dichloride/Bortezomib/Dexamethasone Combination in Relapsed Multiple Myeloma Withdrawn USA | ITA | ISR | GRC | ESP | DEU | CAN | BEL | AUS 2
NCT02609230 Phase I ONC201 A Dose-Escalation Study of Onc201 Administered Every One or Three Weeks in Advanced Solid Tumors and Multiple Myeloma Completed USA 0
NCT02612779 Phase II Dexamethasone + Elotuzumab + Pomalidomide A Study of Elotuzumab in Combination With Pomalidomide and Low Dose Dexamethasone (EPd) in Patients With Multiple Myeloma Relapsed or Refractory to Prior Treatment With Lenalidomide Completed USA 0
NCT02616640 Phase I Pomalidomide Dexamethasone Durvalumab A Study to Determine Dose and Regimen of Durvalumab as Monotherapy or in Combination With Pomalidomide With or Without Dexamethasone in Subjects With Relapsed and Refractory Multiple Myeloma Completed USA | NLD | ITA | FRA | ESP | DEU | CAN 0
NCT02628704 Phase II Carfilzomib + Dexamethasone + Selinexor Selinexor, Carfilzomib, and Dexamethasone Versus Placebo, Carfilzomib, and Dexamethasone in Multiple Myeloma Withdrawn USA 0
NCT02633059 Phase Ib/II Dexamethasone + Idasanutlin + Ixazomib Idasanutlin, Ixazomib Citrate, and Dexamethasone in Treating Patients With Relapsed Multiple Myeloma Completed USA 0
NCT02649790 Phase Ib/II Eltanexor Study of the Safety, Tolerability and Efficacy of KPT-8602 in Patients With Relapsed/Refractory Multiple Myeloma Active, not recruiting USA | FRA | ESP | CAN 1
NCT02654132 Phase II Dexamethasone + Pomalidomide Elotuzumab Trial of Elotuzumab With or Without Pomalidomide and Low-dose Dexamethasone to Treat Refractory and Relapsed and Refractory Multiple Myeloma Completed USA | POL | NLD | ITA | GRC | FRA | ESP | DEU | CAN | AUS 1
NCT02654990 Phase II Bortezomib + Dexamethasone + Panobinostat Panobinostat/Bortezomib/Dexamethasone in Relapsed or Relapsed-and-refractory Multiple Myeloma Completed USA | TUR | SWE | POL | NOR | NLD | LBN | ITA | HUN | GRC | FRA | ESP | DEU | CZE | CAN | BRA | BEL | AUS 4
NCT02655458 Phase I Elotuzumab + Lenalidomide Elotuzumab in Autologous Stem Cell Transplantation (ASCT) and Lenalidomide Maintenance for Multiple Myeloma Completed USA 0
NCT02658396 Phase I Bortezomib + GO-203-2C GO-203-2C + Bortezomib For Relapsed Or Refractory MM Withdrawn USA 0
NCT02658929 Phase I Idecabtagene Vicleucel Study of bb2121 in Multiple Myeloma Completed USA 0
NCT02666209 Phase I Bortezomib + Dexamethasone + Ulocuplumab Dexamethasone + Lenalidomide + Ulocuplumab Early Patient Access Single Named Patient Program for the Use of Ulocuplumab for the Treatment of Multiple Myeloma No longer available USA 0
NCT02675452 Phase I AMG 176 AMG 176 First in Human Trial in Subjects With Relapsed or Refractory Multiple Myeloma and Subjects With Relapsed or Refractory Acute Myeloid Leukemia Completed USA | DEU | CAN | AUS 1
NCT02681302 Phase Ib/II Ipilimumab + Nivolumab Check Point Inhibition After Autologous Stem Cell Transplantation in Patients at High Risk of Post Transplant Recurrence (CPIT001) Terminated USA 0
NCT02684617 Phase I Dinaciclib + Pembrolizumab Study of Pembrolizumab (MK-3475) in Combination With Dinaciclib (MK-7965) in Hematologic Malignancies (MK-3475-155) (KEYNOTE-155) Terminated 0
NCT02685826 Phase I Dexamethasone Durvalumab + Lenalidomide A Study of Durvalumab in Combination With Lenalidomide With and Without Dexamethasone in Subjects With Newly Diagnosed Multiple Myeloma Completed USA | NLD | ITA | FIN | ESP | DNK | DEU | CAN 0
NCT02693535 Phase II Cobimetinib + Vemurafenib Atezolizumab + Talazoparib Regorafenib Larotrectinib Trastuzumab + Tucatinib Ipilimumab + Nivolumab Palbociclib Afatinib Entrectinib Talazoparib Pembrolizumab Temsirolimus Pertuzumab + Trastuzumab Atezolizumab + Pertuzumab/trastuzumab/hyaluronidase-zzxf Crizotinib Abemaciclib Sunitinib Olaparib TAPUR: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancer (TAPUR) Recruiting USA 0
NCT02700841 Phase II Melphalan + PVX-410 Enhancing Anti-Myeloma Vaccine Response After Autologous Stem Cell Transplantation Terminated USA 0
NCT02703779 Phase II Bortezomib Filgrastim + Plerixafor Exploratory Trial to Estimate Proportion of Patients With Tumor Cell Contaminated Leukapheresis Products With and Without Bortezomib With In-vivo Purging - Multiple Myeloma (MM) Completed USA 0
NCT02716805 Phase I Durvalumab + Tremelimumab Phase 1 Study to Assess Safety & Tolerability of Tremelimumab & Durvalumab, Administered With High Dose Chemotherapy and Autologous Stem Cell Transplant Terminated USA 0
NCT02718833 Phase II Bortezomib + Dexamethasone + Elotuzumab + Panobinostat A Study of Elotuzumab With Pomalidomide, Bortezomib, and Dexamethasone in Relapsed Multiple Myeloma Active, not recruiting USA 0
NCT02719613 Phase II Bortezomib + Dexamethasone + Elotuzumab + Lenalidomide Continuing Treatment for Subjects Who Have Participated in a Prior Protocol Investigating Elotuzumab Active, not recruiting USA | TUR | ROU | POL | ITA | HUN | GRC | GBR | ESP | CAN | BEL | AUS 1
NCT02720510 Phase II Panobinostat Bortezomib + Dexamethasone + Lenalidomide A Trial Evaluating Efficacy & Safety of RVD +/- Panobinostat in Transplant Eligible, Newly Diagnosed Multiple Myeloma (NDMM) Terminated USA 0
NCT02722668 Phase II Cyclophosphamide + Fludarabine + Mycophenolate mofetil Sirolimus anti-thymocyte globulin UCB Transplant for Hematological Diseases Using a Non Myeloablative Prep Active, not recruiting USA 0
NCT02722941 Phase II Panobinostat Panobinostat (LBH589): Multiple Myeloma - Autologous Hematopoietic Cell Transplantation (HCT) Completed USA 0
NCT02726581 Phase III Elotuzumab Nivolumab Dexamethasone + Pomalidomide Study of Combinations of Nivolumab, Elotuzumab, Pomalidomide and Dexamethasone in Multiple Myeloma Completed USA | TUR | SWE | NOR | ITA | ISR | GRC | ESP | DNK | DEU | CZE | CHE | CAN | AUT 2
NCT02727803 Phase II anti-thymocyte globulin + Fludarabine + haNK cells + Melphalan anti-thymocyte globulin + Cyclophosphamide + Fludarabine + haNK cells + Rituximab anti-thymocyte globulin + Busulfan + Clofarabine + Fludarabine + haNK cells Personalized NK Cell Therapy in CBT Recruiting USA 0
NCT02755597 Phase III Bortezomib + Dexamethasone Bortezomib + Dexamethasone + Venetoclax A Study Evaluating Venetoclax (ABT-199) in Multiple Myeloma Subjects Who Are Receiving Bortezomib and Dexamethasone as Standard Therapy Completed USA | ITA | IRL | HUN | GBR | FRA | ESP | DEU | CAN | BRA | AUS 5
NCT02757326 Phase Ib/II ABC294640 ABC294640 in Refractory / Relapsed Multiple Myeloma Terminated USA 0
NCT02765854 Phase II Dexamethasone + Ixazomib + Lenalidomide Dexamethasone + Ixazomib Ixazomib and Dexamethasone Versus Ixazomib, Dexamethasone and Lenalidomide, Randomized With NFKB2 Rearrangement Active, not recruiting USA 0
NCT02773030 Phase Ib/II Iberdomide Dexamethasone + Iberdomide Daratumumab + Dexamethasone + Iberdomide Bortezomib + Dexamethasone + Iberdomide A Study to Determine Dose and Tolerability of CC-220 Monotherapy, in Combination With Dexamethasone, and in Combination With Dexamethasone and Daratumumab or Bortezomib in Subjects With Relapsed and Refractory Multiple Myeloma (MM) Active, not recruiting USA | NLD | ITA | ISR | GBR | FRA | ESP | DEU | CAN | AUS 1
NCT02780609 Phase Ib/II Dexamethasone + Melphalan + Selinexor Selinexor Plus High-Dose Melphalan (HDM) Before Autologous Hematopoietic Cell Transplantation for Multiple Myeloma Completed USA 0
NCT02784483 Phase I Atezolizumab Pilot Study Of Anti-Programmed Death Ligand-1 (Anti-PD-L1, Atezolizumab) In Asymptomatic Myeloma Terminated USA 0
NCT02786485 Phase I Rimiducid Rivogenlecleucel Study of Matched Unrelated Donor T Cell Infusion for Hematologic Malignancies After Allo-HSCT Withdrawn 0
NCT02802163 Phase Ib/II Carfilzomib + Dexamethasone + Lenalidomide + Panobinostat Induction Therapy for Multiple Myeloma With Carfilzomib, Lenalidomide,Dexamethasone,Panobinostat Withdrawn 0
NCT02807454 Phase Ib/II Daratumumab + Dexamethasone + Durvalumab + Pomalidomide Daratumumab + Durvalumab A Study to Determine the Safety and Efficacy for the Combination of Durvalumab and Daratumumab in Relapsed and Refractory Multiple Myeloma (FUSIONMM-003) Terminated USA | SWE | ITA | GBR | ESP | DNK | DEU | CAN | BEL 0
NCT02831686 Phase I Dexamethasone + Ixazomib + Selinexor A Study to Test the Combination of Selinexor (KPT-330), Ixazomib, and Dexamethasone in Patients With Myeloma Completed USA 0
NCT02833610 Phase II Denosumab A Study of Denosumab in Multiple Myeloma Patients With Renal Insufficiency Unknown status USA 0
NCT02851056 Phase I Ad5-survivin-transduced autologous DC vaccine + Filgrastim + PCV13 vaccine Survivin Vaccine : Multiple Myeloma Autologous Hematopoietic Cell Transplant (HCT) Completed USA 0
NCT02863991 Phase II ONC201 Oral ONC201 in Relapsed/Refractory Multiple Myeloma Terminated USA 0
NCT02874742 Phase II Daratumumab Bortezomib + Dexamethasone + Lenalidomide Study Comparing Daratumumab, Lenalidomide, Bortezomib, and Dexamethasone (D-RVd) Versus Lenalidomide, Bortezomib, and Dexamethasone (RVd) in Subjects With Newly Diagnosed Multiple Myeloma Completed USA 0
NCT02880228 Phase II Dexamethasone + Lenalidomide + Pembrolizumab Pembrolizumab, Lenalidomide, and Dexamethasone in Treating Patients With Newly Diagnosed Multiple Myeloma Eligible for Stem Cell Transplant Completed USA 0
NCT02890758 Phase I Nogapendekin alfa inbakicept Phase I Trial of Universal Donor NK Cell Therapy in Combination With ALT803 Completed USA 0
NCT02891811 Phase II Carfilzomib + Dexamethasone + Lenalidomide Carfilzomib + Dexamethasone + Thalidomide Patients With Newly Diagnosed Multiple Myeloma Comparing KTd vs. KRd Induction Therapy and Investigating a K-mono Maintenance Strategy Completed DEU | AUT 0
NCT02899052 Phase II Carfilzomib + Dexamethasone + Venetoclax Study of Venetoclax in Combination With Carfilzomib and Dexamethasone in Subjects With Relapsed or Refractory Multiple Myeloma (MM) Active, not recruiting USA | HUN | ESP | AUS 1
NCT02906332 Phase II Pembrolizumab Dexamethasone Pembrolizumab + Lenalidomide Post Autologous Stem Cell Transplant (ASCT) in High-risk Multiple Myeloma (MM) Terminated USA 0
NCT02925234 Phase II Crizotinib Sunitinib Niraparib Olaparib Lorlatinib Erdafitinib Talazoparib Dacomitinib Axitinib Panitumumab The Drug Rediscovery Protocol (DRUP Trial) (DRUP) Recruiting NLD 0
NCT02928029 Phase Ib/II Bortezomib + Dexamethasone + Radium Ra 223 dichloride Study Testing Radium-223 Dichloride in Relapsed Multiple Myeloma Terminated USA | ESP 1
NCT02931110 Phase I CBL0137 Study of IV CBL0137 in Previously Treated Hematological Subjects Terminated USA 0
NCT02943473 Phase II Ibrutinib Study on the Effect of Ibrutinib on High Risk Smoldering Multiple Myeloma Patients Terminated USA 0
NCT02948283 Phase 0 Metformin + Ritonavir Metformin Hydrochloride and Ritonavir in Treating Patients With Relapsed or Refractory Multiple Myeloma or Chronic Lymphocytic Leukemia Completed USA 0
NCT02951819 Phase II Bortezomib + Cyclophosphamide + Daratumumab + Dexamethasone A Study to Evaluate Dara-CyBorD in Previously Untreated and Relapsed Subjects With Multiple Myeloma Completed USA 0
NCT02952573 Phase II Dexamethasone + Erdafitinib Testing JNJ-42756493 In Combination With Dexamethasone in Multiple Myeloma That Came Back After a Period of Improvement Terminated CAN 0
NCT02960646 Phase I Fludarabine + Melphalan CD45RA-depleted donor lymphocytes Cyclophosphamide Tacrolimus Rituximab Engineered Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies Completed USA 0
NCT02963493 Phase II Dexamethasone + Melflufen A Study of Melflufen in Combination With Dexamethasone in Relapsed Refractory Multiple Myeloma Patients (HORIZON) Completed USA | ITA | FRA | ESP 0
NCT02978235 Phase Ib/II TAS4464 A Dose Finding Study Followed by a Safety and Efficacy Study for Patients With Multiple Myeloma or Lymphoma Terminated USA 0
NCT02990338 Phase III Dexamethasone + Isatuximab + Pomalidomide Dexamethasone + Pomalidomide Multinational Clinical Study Comparing Isatuximab, Pomalidomide, and Dexamethasone to Pomalidomide and Dexamethasone in Refractory or Relapsed and Refractory Multiple Myeloma Patients (ICARIA-MM) Completed USA | TUR | SWE | SVK | POL | NZL | NOR | ITA | HUN | GRC | GBR | FRA | ESP | DNK | DEU | CZE | CAN | BEL | AUS 5
NCT02992483 Phase I MIK665 Phase I Study of MIK665, a Mcl-1 Inhibitor, in Patients With Refractory or Relapsed Lymphoma or Multiple Myeloma Completed USA | ITA | FRA | ESP | DEU | AUS 1
NCT02998047 Phase I Lintuzumab-Ac225 A Phase I Study of Lintuzumab-Ac225 in Patients With Refractory Multiple Myeloma Terminated USA 0
NCT03000452 Phase II Daratumumab + Durvalumab A Study to Determine the Efficacy of the Combination of Daratumumab (DARA) Plus Durvalumab (DURVA) (D2) in Subjects With Relapsed and Refractory Multiple Myeloma (RRMM) (FUSION-MM-005) Completed USA | SWE | NLD | GRC | ESP | AUT 0
NCT03003728 Phase II Elotuzumab + Melphalan + Nogapendekin alfa inbakicept 2015-10: Expanded Natural Killer Cells and Elotuzumab for High-Risk Myeloma Post- Autologous Stem Cell Transplant (ASCT) Withdrawn USA 0
NCT03004287 Phase II Melphalan Carfilzomib Cisplatin Cyclophosphamide Lenalidomide Dexamethasone Daratumumab Bortezomib Etoposide Doxorubicin Thalidomide 2015-12: A Study Exploring the Use of Early and Late Consolidation/Maintenance Therapy Active, not recruiting USA 0
NCT03015792 Phase Ib/II Dexamethasone + Ibrutinib + Lenalidomide Ibrutinib, Lenalidomide, and Dexamethasone in Treating Patients With Multiple Myeloma Ineligible for Transplant Terminated USA 0
NCT03017820 Phase I VSV-hIFNbeta-NIS VSV-hIFNbeta-NIS in Treating Patients With Relapsed or Refractory Multiple Myeloma, Acute Myeloid Leukemia, or T-cell Lymphoma Recruiting USA 0
NCT03018405 Phase Ib/II NKR-2 cells A Dose Escalation Phase I Study to Assess the Safety and Clinical Activity of Multiple Cancer Indications (THINK) Unknown status USA | BEL 0
NCT03019666 Phase I Allogeneic NAM NK cells Cyclophosphamide + Fludarabine Ph I Trial of NAM NK Cells and IL-2 for Adult Pts With MM and NHL Completed USA 0
NCT03030261 Phase II Melphalan Dexamethasone + Elotuzumab + Pomalidomide Elotuzumab, Pomalidomide, & Dexamethasone (Elo-Pom-Dex) With Second Autologous Stem Cell Transplantation for Relapsed Multiple Myeloma Active, not recruiting USA | CAN 0
NCT03031730 Phase I Carfilzomib + Dexamethasone + KRT-232 + Lenalidomide MDM2 Inhibitor AMG-232, Carfilzomib, Lenalidomide, and Dexamethasone in Treating Patients With Relapsed or Refractory Multiple Myeloma Terminated USA 0
NCT03068351 Phase I TEN-010 Daratumumab + TEN-010 Study of Bromodomain and Extra-Terminal Protein (BET) Inhibitor RO6870810 as Mono- and Combination Therapy in Advanced Multiple Myeloma Completed USA | GBR | AUS 0
NCT03091257 Phase I Dabrafenib + Trametinib Dabrafenib Trametinib A Study of Dabrafenib and/or Trametinib in Patients With Relapsed and/or Refractory Multiple Myeloma Recruiting USA 0
NCT03104270 Phase II Carfilzomib + Dexamethasone + Elotuzumab + Pomalidomide Combination Study for High Risk Multiple Myeloma Patients Terminated USA 0
NCT03104842 Phase II Carfilzomib + Dexamethasone + Isatuximab + Lenalidomide Evaluation iNduction, Consolidation and Maintenance Treatment With Isatuximab , Carfilzomib, LEnalidomide and Dexamethasone Active, not recruiting DEU 0
NCT03106428 Phase I MEDI7247 A Multiple Ascending Dose Study of MEDI7247 in Patients With Selected Relapsed/Refractory Hematological Malignancies Completed USA | FRA 1
NCT03110562 Phase III Bortezomib + Dexamethasone + Selinexor Bortezomib + Dexamethasone Bortezomib, Selinexor, and Dexamethasone in Patients With Multiple Myeloma (BOSTON) Completed USA | ROU | POL | ITA | ISR | HUN | GRC | GBR | FRA | ESP | DEU | CZE | CAN | BGR | BEL | AUT | AUS 4
NCT03110822 Phase I Lenalidomide + Methylprednisolone + Ruxolitinib A Phase 1 Study of Ruxolitinib, Steroids and Lenalidomide for Relapsed/Refractory Multiple Myeloma (RRMM) Patients Recruiting USA 0
NCT03111992 Phase I LCL161 + Spartalizumab CJM112 + Spartalizumab Spartalizumab Study of Single Agent CJM112, and PDR001 in Combination With LCL161 or CJM112 in Patients With Multiple Myeloma Completed USA | ITA | ESP | DEU 0
NCT03143985 Phase I Pomalidomide + Vactosertib TEW-7197 in Combination w/ Pomalidomide in Relapsed or Relapsed and Refractory Multiple Myeloma Completed USA 0
NCT03145181 Phase I Teclistamab Dose Escalation Study of JNJ-64007957, a Humanized BCMA CD3 DuoBody® Antibody, in Participants With Relapsed or Refractory Multiple Myeloma Active, not recruiting USA | SWE | NLD | FRA | ESP 0
NCT03151811 Phase III Dexamethasone + Pomalidomide Dexamethasone + Melflufen A Study of Melflufen-dex or Pomalidomide-dex for RRMM Patients Refractory to Lenalidomide (OCEAN) Terminated USA | ROU | POL | NOR | NLD | LTU | ITA | ISR | HUN | GRC | GBR | FRA | EST | ESP | DNK | CZE | BEL | AUT 3
NCT03168100 Phase II Bortezomib + Dexamethasone + Lenalidomide Dexamethasone + Elotuzumab + Lenalidomide 2017-03: A Single-Arm, Open-label Study of Anti-Signaling Lymphocytic Activation Molecule F7 (Anti-SLAMF7) Monoclonal Antibody (mAb) Therapy After Autologous Stem Cell Transplant in Patients With Multiple Myeloma Withdrawn USA 0
NCT03168438 Phase II Letetresgene autoleucel Letetresgene autoleucel + Pembrolizumab Letetresgene Autoleucel Engineered T Cells Alone and in Combination With Pembrolizumab in NY-ESO-1 Positive Multiple Myeloma Terminated USA 0
NCT03194867 Phase Ib/II Cemiplimab + Isatuximab Isatuximab in Combination With REGN2810 in Relapsed/Refractory Multiple Myeloma (RRMM) Patients Completed USA | ITA | HUN | GRC | FRA | ESP | CZE | CAN | BRA | AUS 0
NCT03201250 Phase Ib/II Cabozantinib + Carfilzomib + Dexamethasone Cabozantinib as a Targeted Strategy to Reverse Carfilzomib Resistance in Refractory Multiple Myeloma Terminated USA 0
NCT03215030 Phase Ib/II Dexamethasone + TAK-573 TAK-573 A Study to Investigate the Safety, Tolerability, Efficacy, Pharmacokinetics, and Immunogenicity of TAK-573 in Participants With Refractory Multiple Myeloma (MM) Active, not recruiting USA | TUR | NOR | ITA | ISR | GRC | GBR | FRA | ESP | DEU | CAN 5
NCT03218683 Phase I AZD5991 Study of AZD5991 in Relapsed or Refractory Haematologic Malignancies. Terminated USA 0
NCT03221634 Phase II Daratumumab + Pembrolizumab Efficacy and Safety Study of Pembrolizumab (MK-3475) in Combination With Daratumumab in Participants With Relapsed Refractory Multiple Myeloma (MK-3475-668/KEYNOTE-668) Withdrawn USA | SWE | ISR | FRA | ESP | CAN 0
NCT03227432 Phase II Dexamethasone + Elotuzumab + Nivolumab + Pomalidomide Elotuzumab + Nivolumab An Exploratory Study to Evaluate the Combination of Elotuzumab and Nivolumab With and Without Pomalidomide in Relapsed Refractory Multiple Myeloma Withdrawn USA 0
NCT03246529 Phase III Filgrastim BKT140 + Filgrastim A Phase III, Safety, Tolerability and Efficacy of Combination Treatment of BL-8040 and G-GSF as Compared to Placebo and G-CSF for thE MobilizatioN of HematopoiEtic Stem Cells for Autologous TransplantatIon in SubjectS With MM (GENESIS) Active, not recruiting USA | ITA | HUN | ESP | DEU 0
NCT03256045 Phase II Carfilzomib + Dexamethasone + Panobinostat Panobinostat, Carfilzomib and Dexamethasone in Patients With Relapsed or Refractory Multiple Myeloma Terminated USA 0
NCT03263637 Phase I AZD4573 Study to Assess Safety, Tolerability, Pharmacokinetics and Antitumor Activity of AZD4573 in Relapsed/Refractory Haematological Malignancies Completed NLD | GBR | DEU 0
NCT03266692 Phase I ACTR087 + SEA-BCMA Study of ACTR087 in Combination With SEA-BCMA in Subjects With Relapsed or Refractory Multiple Myeloma Terminated USA 0
NCT03267888 Phase I Pembrolizumab Pembrolizumab and Radiation Therapy in Patients With Relapsed or Refractory Multiple Myeloma Completed USA 0
NCT03269136 Phase I Elranatamab-bcmm Phase 1 Study Of PF-06863135, A BCMA- CD3 Bispecific Ab, In Relapse/ Refractory Multiple Myeloma Completed USA | CAN 0
NCT03275103 Phase I Cevostamab Dose-Escalation Study of BFCR4350A in Participants With Relapsed or Refractory Multiple Myeloma (R/R MM) Recruiting USA | ESP | CAN | AUS 0
NCT03275285 Phase III Carfilzomib + Dexamethasone + Isatuximab Carfilzomib + Dexamethasone Multinational Clinical Study Comparing Isatuximab, Carfilzomib And Dexamethasone To Carfilzomib And Dexamethasone In Relapse And/Or Refractory Multiple Myeloma Patients (IKEMA) Active, not recruiting USA | TUR | NZL | ITA | HUN | GRC | GBR | FRA | ESP | CZE | CAN | BRA | AUS 3
NCT03287908 Phase I AMG 701 A Phase 1/2 Study of AMG 701 in Subjects With Multiple Myeloma Terminated USA | NLD | DEU | CAN | AUS 1
NCT03288480 Phase I Imifoplatin A Phase 1/2a Dose-Finding Study of PT-112 in Patients With Relapsed or Refractory Multiple Myeloma Completed USA 0
NCT03288493 Phase I P-BCMA-101 CAR-T cells P-BCMA-101 Tscm CAR-T Cells in the Treatment of Patients With Multiple Myeloma (MM) Terminated USA 0
NCT03297606 Phase II Bosutinib Palbociclib Vismodegib Ipilimumab + Nivolumab Cobimetinib + Vemurafenib Temsirolimus Olaparib Erlotinib Crizotinib Sunitinib Afatinib Dasatinib Pertuzumab + Trastuzumab Axitinib Canadian Profiling and Targeted Agent Utilization Trial (CAPTUR) (CAPTUR) Recruiting CAN 0
NCT03309111 Phase I ISB 1342 Study of GBR 1342, a CD38/CD3 Bispecific Antibody, in Subjects With Previously Treated Multiple Myeloma Completed USA | FRA 0
NCT03314181 Phase II Bortezomib + Daratumumab + Dexamethasone + Venetoclax Daratumumab + Dexamethasone Daratumumab + Dexamethasone + Venetoclax A Study of Combination Therapy With Venetoclax, Daratumumab and Dexamethasone (With and Without Bortezomib) in Subjects With Relapsed or Refractory Multiple Myeloma Active, not recruiting USA | FRA | DNK | DEU | CAN | AUS 1
NCT03315026 Phase II Siltuximab Siltuximab to Decrease Symptom Burden After Autologous Stem Cell Transplantation for Patients With Multiple Myeloma and AL Amyloidosis Active, not recruiting USA 0
NCT03319667 Phase III Bortezomib + Dexamethasone + Lenalidomide Dexamethasone + Isatuximab + Lenalidomide Bortezomib + Dexamethasone + Isatuximab + Lenalidomide Clinical Benefit of SAR650984, Bortezomib, Lenalidomide and Dexamethasone Combination in NDMM Patients Not Eligible for Transplant (IMROZ) Active, not recruiting USA | TUR | SWE | POL | NZL | LTU | ITA | GRC | FRA | ESP | DNK | DEU | CZE | BEL | AUS 6
NCT03333746 Phase II Lenalidomide + Nivolumab Lenalidomide and Nivolumab in Treating Patients With Relapsed or Refractory Multiple Myeloma Terminated USA 0
NCT03338972 Phase I Cyclophosphamide + Fludarabine Anti-BCMA CAR-T cells Immunotherapy With BCMA CAR-T Cells in Treating Patients With BCMA Positive Relapsed or Refractory Multiple Myeloma Completed USA 0
NCT03346135 Phase II Melphalan Daratumumab Daratumumab After Stem Cell Transplant in Treating Patients With Multiple Myeloma Active, not recruiting USA 0
NCT03352765 Phase I Bendamustine + Melphalan + Rituximab A Phase I Study of Bendamustine and Melphalan Conditioning and Autologous Stem Cell Transplantation for Treatment of Multiple Myeloma and Relapsed/Refractory B-cell Lymphoma in Elderly Patients Active, not recruiting USA 0
NCT03357952 Phase I Cetrelimab + Daratumumab A Study of JNJ-63723283, an Anti-programmed Death-1 Monoclonal Antibody, Administered in Combination With Daratumumab, Compared With Daratumumab Alone in Participants With Relapsed or Refractory Multiple Myeloma Completed ISR | ESP | BEL 0
NCT03361306 Phase II Carfilzomib + Dexamethasone + Elotuzumab + Lenalidomide LCI-HEM-MYE-CRD-002: Carfilzomib-Revlimid-Dexamethasone-Elotuzumab in Relapsed/Refractory Multiple M Active, not recruiting USA 0
NCT03361748 Phase II Idecabtagene Vicleucel Efficacy and Safety Study of bb2121 in Subjects With Relapsed and Refractory Multiple Myeloma (KarMMa) (bb2121) Completed USA | ITA | FRA | ESP | DEU | CAN | BEL 1
NCT03374085 Phase I CC-92480 + Dexamethasone A Safety, PK and Efficacy Study of CC-92480 in Combination With Dexamethasone in Subjects With Relapsed and Refractory Multiple Myeloma Active, not recruiting USA | GRC | GBR | FIN | ESP | DNK | CAN | BEL | AUS 2
NCT03399799 Phase I Talquetamab-tgvs Dose Escalation Study of JNJ-64407564 in Participants With Relapsed or Refractory Multiple Myeloma Recruiting USA | NLD | ESP | BEL 0
NCT03411031 Phase II Elotuzumab + Lenalidomide Dexamethasone Elotuzumab Plus Lenalidomide (Elo/Rev) for Serologic Relapse/Progression While on Lenalidomide Terminated USA 0
NCT03412565 Phase II Bortezomib + Daratumumab + Dexamethasone + Melphalan + Prednisone Daratumumab + Dexamethasone + Lenalidomide Bortezomib + Daratumumab + Dexamethasone + Lenalidomide A Study to Evaluate Subcutaneous Daratumumab in Combination With Standard Multiple Myeloma Treatment Regimens Completed USA | ISR | GBR | FRA | ESP | DEU | CZE | BRA 1
NCT03424603 Phase I STRO-001 Study of STRO-001, an Anti-CD74 Antibody Drug Conjugate, in Patients With Advanced B-Cell Malignancies Completed USA 0
NCT03428373 Phase II Dexamethasone + Lenalidomide + Rivaroxaban Aspirin + Dexamethasone + Lenalidomide ASA vs. Rivaroxaban in Newly Diagnosed or Relapsed and Refractory Multiple Myeloma Patients Treated With Len-Dex Combination Therapy. (RithMM) Active, not recruiting CAN 0
NCT03439280 Phase Ib/II Dexamethasone + Mezagitamab + Pomalidomide Mezagitamab A Study to Investigate the Safety, Tolerability, Efficacy, Pharmacokinetics, and Immunogenicity of TAK-079 Administered Subcutaneously as a Single Agent in Participants With Relapsed/Refractory (r/r) Multiple Myeloma (MM) Completed USA 0
NCT03441958 Phase Ib/II Cyclophosphamide + ECT-001 cord blood cells + Fludarabine + Mycophenolate mofetil + Tacrolimus ECT-001 (UM171) Expanded Cord Blood Transplant to Treat High-risk Multiple Myeloma Active, not recruiting CAN 0
NCT03457142 Phase II BMS-188667 + Dexamethasone + Ixazomib Abatacept, Ixazomib Citrate, and Dexamethasone in Treating Patients With Multiple Myeloma Resistant to Chemotherapy Active, not recruiting USA 0
NCT03464916 Phase I CAR2 anti-CD38 A2 CAR T cells Study to Evaluate the Safety and Efficacy of Anti-CD38 CAR-T in Relapsed or Refractory Multiple Myeloma Patients Completed USA 0
NCT03465540 Phase I AMG 397 + Azacitidine AMG 397 + Dexamethasone AMG 397 Safety, Tolerability, Pharmacokinetics and Efficacy of AMG 397 in Subjects With Selected Relapsed or Refractory Hematological Malignancies Terminated USA | ITA | GRC | FRA | AUS 1
NCT03477539 Phase II Daratumumab + Lenalidomide Daratumumab Daratumumab in Treating Transplant-Eligible Participants With Multiple Myeloma Active, not recruiting USA 0
NCT03480360 Phase III Cyclophosphamide + Fludarabine Filgrastim + Mycophenolate mofetil + Tacrolimus Haploidentical Allogeneic Peripheral Blood Transplantation: Examining Checkpoint Immune Regulators' Expression Active, not recruiting USA 0
NCT03481556 Phase Ib/II Bortezomib + Dexamethasone + Melflufen Daratumumab + Dexamethasone + Melflufen Study of Melflufen + Dex With Bortezomib or Daratumumab in Patients With RRMM (ANCHOR) Terminated USA | FRA | ESP | CZE 0
NCT03486067 Phase I CC-93269 Study of CC-93269, a BCMA x CD3 T Cell Engaging Antibody, in Subjects With Relapsed and Refractory Multiple Myeloma Active, not recruiting USA | SWE | ITA | ESP | DEU 1
NCT03489525 Phase I MEDI2228 MEDI2228 in Subjects With Relapsed/Refractory Multiple Myeloma (MEDI2228) Completed USA | GRC | ESP | AUS 0
NCT03490344 Phase II Daratumumab + Lenalidomide Short Course Daratumumab in Patients With Multiple Myeloma Completed USA 0
NCT03492138 Phase Ib/II Dexamethasone + Ixazomib + ONC201 Ixazomib, ONC201, and Dexamethasone in Relapsed/Refractory Multiple Myeloma Terminated USA 0
NCT03500445 Phase II Carfilzomib + Daratumumab + Dexamethasone + Lenalidomide Daratumumab, Carfilzomib, Lenalidomide and Low Dose Dexamethasone (DKRd) in Newly Diagnosed, Multiple Myeloma Active, not recruiting USA 0
NCT03502577 Phase I Anti-BCMA CAR-T cells + Cyclophosphamide + Fludarabine + LY3039478 BCMA-Specific CAR T-Cells Combined With a Gamma Secretase Inhibitor (JSMD194) to Treat Relapsed or Persistent Multiple Myeloma Terminated USA 0
NCT03503968 Phase Ib/II MDG1011 TCR Modified T Cells MDG1011 in High Risk Myeloid and Lymphoid Neoplasms Terminated DEU 0
NCT03506360 Phase II Dexamethasone + Ixazomib + Pembrolizumab Pembrolizumab, Ixazomib Citrate, and Dexamethasone in Treating Participants With Relapsed Multiple Myeloma Completed USA 0
NCT03506802 Phase I Filgrastim + Plerixafor Lenalidomide Aldesleukin + LV-NY-ESO TCR/sr39TK PBSC + RV-NY-ESO TCR PBMC Melphalan TCR Genetically Engineered PBMC and PBSC After Melphalan Conditioning Regimen in Treating Participants With Relapsed and Refractory Multiple Myeloma Withdrawn USA 0
NCT03525678 Phase II belantamab mafodotin-blmf A Study to Investigate the Efficacy and Safety of Two Doses of GSK2857916 in Subjects With Multiple Myeloma Who Have Failed Prior Treatment With an Anti-CD38 Antibody Completed USA | ITA | GBR | FRA | ESP | DEU | CAN | AUS 0
NCT03530683 Phase I TTI-622 A Trial of TTI-622 in Patients With Advanced Relapsed or Refractory Lymphoma or Myeloma Terminated USA 0
NCT03531736 Phase I Rituximab Cyclophosphamide + Fludarabine T Cell Depleted Allogeneic Hematopoietic Stem Cell Transplantation Conditioned With a Reduced Intensity Regimen in Patients With Hematologic Malignancies and Aplastic Anemia Active, not recruiting USA 0
NCT03537482 Phase I APG-2575 APG-2575 Study of Safety, Tolerability ,PK/PD in Patients With Hematologic Malignancies Recruiting USA | AUS 0
NCT03539744 Phase III Dexamethasone + Pomalidomide Dexamethasone + Venetoclax A Study of Venetoclax and Dexamethasone Compared With Pomalidomide and Dexamethasone in Subjects With Relapsed or Refractory Multiple Myeloma (CANOVA) Active, not recruiting USA | TUR | SWE | ITA | ISR | GRC | GBR | FRA | ESP | DNK | DEU | CZE | CAN | AUS 6
NCT03544281 Phase II belantamab mafodotin-blmf + Bortezomib + Dexamethasone belantamab mafodotin-blmf + Dexamethasone + Lenalidomide To Evaluate Safety, Tolerability, and Clinical Activity of the Antibody-drug Conjugate, GSK2857916 Administered in Combination With Lenalidomide Plus Dexamethasone (Arm A), or in Combination With Bortezomib Plus Dexamethasone (Arm B) in Subjects With Relapsed/Refractory Multiple Myeloma (RRMM) Completed USA | GBR | ESP | CAN | AUS 0
NCT03548207 Phase Ib/II Ciltacabtagene autoleucel A Study of JNJ-68284528, a Chimeric Antigen Receptor T Cell (CAR-T) Therapy Directed Against B-Cell Maturation Antigen (BCMA) in Participants With Relapsed or Refractory Multiple Myeloma Completed USA 1
NCT03556332 Phase II Carfilzomib + Daratumumab + Dexamethasone + Lenalidomide A Study of Carfilzomib, Lenalidomide, Dexamethasone and Daratumumab for Patients With Relapsed/Refractory Myeloma With Salvage Autologous Hematopoietic Cell Transplantation Active, not recruiting USA 0
NCT03567616 Phase II Dexamethasone + Pomalidomide + Venetoclax A Study of Venetoclax in Combination With Pomalidomide and Dexamethasone in Subjects With Relapsed or Refractory Multiple Myeloma Terminated USA | GBR | ESP 0
NCT03582033 Phase I SEA-BCMA A Safety Study of SEA-BCMA in Patients With Multiple Myeloma Terminated USA 0
NCT03589222 Phase II Bortezomib + Daratumumab + Dexamethasone + Selinexor SELIBORDARA: Selinexor, Bortezomib and Daratumumab in Multiple Myeloma Unknown status ESP 0
NCT03591614 Phase I DKK1 dendritic cell vaccine Dendritic Cell DKK1 Vaccine for Monoclonal Gammopathy and Stable or Smoldering Myeloma Withdrawn USA 0
NCT03601078 Phase II Idecabtagene Vicleucel An Efficacy and Safety Study of bb2121 in Subjects With Relapsed and Refractory Multiple Myeloma and in Subjects With High-Risk Multiple Myeloma Having Progressed Within One Year of Initial Treatment (KarMMa-2) Recruiting USA | ITA | GBR | FRA | ESP | DEU 0
NCT03602612 Phase I Anti-BCMA CAR-T cells + Cyclophosphamide + Fludarabine T Cells Expressing a Novel Fully-Human Anti-BCMA CAR for Treating Multiple Myeloma Active, not recruiting USA 0
NCT03605719 Phase I Carfilzomib + Dexamethasone + Nivolumab + Pelareorep Carfilzomib + Dexamethasone + Nivolumab Dexamethasone, Carfilzomib, & Nivolumab With Reovirus for Relapsed/Refractory Multiple Myeloma Completed USA 0
NCT03607643 Phase Ib/II Temozolomide Bevacizumab + Fluorouracil + Irinotecan + Leucovorin + Oxaliplatin Bevacizumab + Cannabidiol + Fluorouracil + Irinotecan + Leucovorin + Oxaliplatin Bortezomib Bortezomib + Cannabidiol Cannabidiol + Gemcitabine Cannabidiol + Temozolomide Gemcitabine A Study of the Efficacy of Cannabidiol in Patients With Multiple Myeloma, Glioblastoma Multiforme, and GI Malignancies Unknown status USA 0
NCT03622775 Phase II Daratumumab Daratumumab in Treating Participants With Relapsed Multiple Myeloma After Stem Cell Transplant Active, not recruiting USA 0
NCT03634800 Phase II Nivolumab Radiotherapy With Immunotherapy for Systemic Effect in Myeloma (RISE-M) (RISE-M) Terminated USA 0
NCT03650491 Phase I FOR46 A Study of FOR46 in Patients With Relapsed or Refractory Multiple Myeloma (RRMM) Completed USA 0
NCT03651128 Phase III Bortezomib + Daratumumab + Dexamethasone Idecabtagene Vicleucel Dexamethasone + Ixazomib + Lenalidomide Daratumumab + Dexamethasone + Pomalidomide Efficacy and Safety Study of bb2121 Versus Standard Triplet Regimens in Subjects With Relapsed and Refractory Multiple Myeloma (RRMM) (KarMMa-3) Active, not recruiting USA | SWE | NOR | NLD | ITA | GBR | FRA | ESP | DEU | CHE | CAN | BEL 1
NCT03652064 Phase III Bortezomib + Dexamethasone + Lenalidomide Bortezomib + Daratumumab + Dexamethasone + Lenalidomide Dexamethasone + Lenalidomide Daratumumab + Dexamethasone + Lenalidomide A Study Comparing Daratumumab, VELCADE (Bortezomib), Lenalidomide, and Dexamethasone (D-VRd) With VELCADE, Lenalidomide, and Dexamethasone (VRd) in Participants With Untreated Multiple Myeloma and for Whom Hematopoietic Stem Cell Transplant is Not Planned as Initial Therapy Active, not recruiting USA | TUR | POL | NLD | ISR | GBR | FRA | ESP | DEU | CZE | CAN | BRA 1
NCT03657420 Phase I Dexamethasone + Nab-rapamycin + Pomalidomide Safety and Efficacy of ABI-009 (Nab-rapamycin) in Combination With Pomalidomide and Dexamethasone for Relapsed and Refractory Multiple Myeloma Withdrawn USA 0
NCT03669445 Phase II Daratumumab + Dexamethasone + Ixazomib + Lenalidomide Study Association of Lenalidomide, Ixazomib, Dexamethasone and Daratumumab in Newly Diagnosed Standard Risk Multiple Myeloma (IFM2018-01) Recruiting FRA 0
NCT03672318 Phase I ATLCAR.CD138 + Cyclophosphamide + Fludarabine Study of ATLCAR.CD138 Cells for Relapsed/Refractory Multiple Myeloma Recruiting USA 0
NCT03687125 Phase Ib/II Tinostamustine Tinostamustine Conditioning and Autologous Stem Cell (TITANIUM1) Terminated USA | NOR | CHE 0
NCT03701321 Phase Ib/II Bortezomib + Daratumumab + Dexamethasone Bortezomib + Daratumumab + Dexamethasone + Venetoclax Daratumumab, Bortezomib, and Dexamethasone With or Without Venetoclax in Treating Patients With Relapsed or Refractory Multiple Myeloma Withdrawn USA 0
NCT03702725 Phase I Dexamethasone + Ibrutinib + Lenalidomide Study of Ibrutinib in Combination With Revlimid/Dexamethasone in Relapsed/Refractory Multiple Myeloma Active, not recruiting USA 0
NCT03710421 Phase I CS1-CAR T cells + Cyclophosphamide + Fludarabine CS1-CAR T Therapy Following Chemotherapy in Treating Patients With Relapsed or Refractory CS1 Positive Multiple Myeloma Recruiting USA 0
NCT03713294 Phase II Dexamethasone + Elotuzumab + Pomalidomide Dexamethasone, Elotuzumab, and Pomalidomide in Treating Patients With Refractory Multiple Myeloma Active, not recruiting USA 0
NCT03715478 Phase Ib/II belantamab mafodotin-blmf + Dexamethasone + Pomalidomide Multi-Center Study of GSK2857916 in Combination With Pomalidomide and Dex Active, not recruiting CAN 0
NCT03729804 Phase III Bortezomib + Dexamethasone + Lenalidomide Carfilzomib + Dexamethasone + Lenalidomide Carfilzomib, Lenalidomide, and Dexamethasone Versus Bortezomib, Lenalidomide and Dexamethasone (KRd vs. VRd) in Patients With Newly Diagnosed Multiple Myeloma (COBRA) ((COBRA)) Active, not recruiting USA 0
NCT03732703 Phase Ib/II Dexamethasone + Enasidenib + Ixazomib + Pomalidomide Cobimetinib + Dexamethasone + Ixazomib + Pomalidomide Dexamethasone + Erdafitinib + Ixazomib + Pomalidomide Dexamethasone + Ixazomib + Pomalidomide + Venetoclax Abemaciclib + Dexamethasone + Ixazomib + Pomalidomide Daratumumab + Dexamethasone + Ixazomib + Pomalidomide Myeloma-Developing Regimens Using Genomics (MyDRUG) (MyDRUG) Unknown status USA 0
NCT03741127 Phase I Rimiducid Long-Term Follow-Up Study for Subjects Treated With P-BCMA-101 Active, not recruiting USA 0
NCT03742297 Phase III Carfilzomib + Dexamethasone + Lenalidomide Carfilzomib + Daratumumab + Dexamethasone + Lenalidomide Bortezomib + Dexamethasone + Lenalidomide + Melphalan + Prednisone Treatment for Elderly Fit Newly Diagnosed Multiple Myeloma Patients Aged Between 65 and 80 Years Active, not recruiting ESP 0
NCT03755154 Phase I VOB560 Study of a New Intravenous Drug, Called S65487, in Patients With Acute Myeloid Leukemia, Non Hodgkin Lymphoma, Multiple Myeloma or Chronic Lymphocytic Leukemia Terminated GBR | FRA | ESP | AUS 0
NCT03757221 Phase II Daratumumab + Ixazomib Ixazomib -Daratumumab Without Dexamethasone (IDara) in Elderly Relapse Refractory Multiple Myeloma (IDARA) Recruiting FRA 0
NCT03761108 Phase Ib/II Linvoseltamab First in Human (FIH) Study of REGN5458 in Patients With Relapsed or Refractory Multiple Myeloma Recruiting USA | GBR | ESP | DEU | BEL 2
NCT03763162 Phase II Bortezomib + Daratumumab + Dexamethasone Daratumumab + Dexamethasone + Ixazomib Daratumumab, Bortezomib, and Dexamethasone Followed by Daratumumab, Ixazomib, and Dexamethasone in Treating Patients With Relapsed or Refractory Multiple Myeloma Active, not recruiting USA 0
NCT03770260 Phase I Ixazomib + MLN4924 Ixazomib and Pevonedistat in Treating Patients With Multiple Myeloma That Has Come Back or Does Not Respond to Treatment Completed USA 0
NCT03773107 Phase Ib/II Carfilzomib + Dexamethasone + Ruxolitinib LCI-HEM-MYE-CRD-004 (MMRC-073 CARJAK): Study of CRD for Carfilzomib-Refractory Multiple Myeloma Completed USA 0
NCT03782064 Phase II DC myeloma fusion vaccine + Nivolumab Dendritic Cell (DC)/Myeloma Fusions in Combination With Nivolumab in Patients With Relapsed Multiple Myeloma Terminated USA 0
NCT03785184 Phase II Dexamethasone + Lenalidomide + Venetoclax A Study of Venetoclax Plus Lenalidomide and Dexamethasone for the Treatment of Newly Diagnosed t(11;14)-Positive Multiple Myeloma in Subjects Who Are Ineligible for High-Dose Therapy Withdrawn USA | ESP | CAN | AUS 0
NCT03829020 Phase I Metformin + Nelfinavir Bortezomib + Metformin + Nelfinavir Metformin and Nelfinavir in Treating Patients With Relapsed and/or Refractory Multiple Myeloma Completed USA 0
NCT03829371 FDA approved Dexamethasone + Lenalidomide Bortezomib + Melphalan + Prednisone STUDY COMPARING TWO STANDARD TREATMENTS IN AUTOLOGOUS STEM CELL TRANSPLANTATION INELIGIBLE POPULATION AFFECTED BY MULTIPLE MYELOMA Recruiting ITA 0
NCT03837509 Phase Ib/II Daratumumab + INCB001158 Daratumumab INCB001158 Combined With Subcutaneous (SC) Daratumumab, Compared to Daratumumab SC, in Relapsed or Refractory Multiple Myeloma Terminated USA | ESP | DEU 0
NCT03841565 Phase II Daratumumab + Dexamethasone + Pomalidomide Daratumumab, Pomalidomide, and Dexamethasone in Treating Patients With Relapsed Multiple Myeloma Withdrawn USA 0
NCT03848845 Phase II belantamab mafodotin-blmf + Pembrolizumab Study Evaluating Safety, Tolerability and Clinical Activity of GSK2857916 in Combination With Pembrolizumab in Subjects With Relapsed/Refractory Multiple Myeloma (RRMM) (DREAMM 4) Completed USA | ESP | DEU | CAN 0
NCT03859427 Phase III Carfilzomib + Dexamethasone + Lenalidomide A Study Comparing Once-weekly vs Twice-weekly Carfilzomib in Combination With Lenalidomide and Dexamethasone in Subjects With Relapsed or Refractory Multiple Myeloma (ARROW2) Completed USA | TUR | SWE | SVK | ROU | NLD | LTU | GRC | FRA | FIN | ESP | DEU | CZE | BGR | AUT 2
NCT03871829 Phase II Carfilzomib + Daratumumab + Dexamethasone Carfilzomib + Dexamethasone Daratumumab Retreatment in Participants With Multiple Myeloma Who Have Been Previously Treated With Daratumumab Terminated USA | POL | NLD | ITA | GRC | FRA | ESP | DNK | DEU | CAN | BRA | BEL 1
NCT03896737 Phase II Bortezomib + Cyclophosphamide + Daratumumab + Dexamethasone Ixazomib Bortezomib + Dexamethasone + Thalidomide Daratumumab + Ixazomib Daratumumab-bortezomib-dexamethasone (Dara-VCd) vs Bortezomib-Thalidomide-Dexamethasone (VTd), Then Maintenance With Ixazomib (IXA) or IXA-Dara Active, not recruiting ITA | GRC | CZE 0
NCT03900442 Phase I GGTI-2418 Phase 1 Study of PTX-100 in Patients With Advanced Malignancies Unknown status AUS 0
NCT03901963 Phase III Daratumumab + Lenalidomide Lenalidomide A Study of Daratumumab Plus Lenalidomide Versus Lenalidomide Alone as Maintenance Treatment in Participants With Newly Diagnosed Multiple Myeloma Who Are Minimal Residual Disease Positive After Frontline Autologous Stem Cell Transplant (AURIGA) Active, not recruiting USA | CAN 0
NCT03910439 Phase II Avelumab Avelumab in Combination With Hypofractionated Radiotherapy in Patients With Relapsed Refractory Multiple Myeloma Terminated USA 0
NCT03915184 Phase I Anti-BCMA CAR-T cells Clinical Trial to Evaluate CT053 in Patients With Relapsed and/or Refractory Multiple Myeloma Active, not recruiting USA | CAN 0
NCT03933735 Phase I ABBV-383 A Study of TNB-383B in Subjects With Relapsed or Refractory Multiple Myeloma Active, not recruiting USA | DEU 0
NCT03937635 Phase III Dexamethasone + Lenalidomide Daratumumab + Dexamethasone + Lenalidomide Lenalidomide, and Dexamethasone With or Without Daratumumab in Treating Patients With High-Risk Smoldering Myeloma Recruiting USA 1
NCT03942224 Phase II Daratumumab + Dexamethasone + Ixazomib Bortezomib + Daratumumab + Dexamethasone Daratumumab, Ixazomib, & Dexamethasone With or Without Bortezomib in Patients With Newly Diagnosed Multiple Myeloma (DeRIVE) Active, not recruiting USA 0
NCT03948035 Phase III Carfilzomib + Dexamethasone + Lenalidomide Carfilzomib + Dexamethasone + Elotuzumab + Lenalidomide Elotuzumab in Combination With Carfilzomib, Lenalidomide and Dexamethasone (E-KRd) Versus KRd in MM Active, not recruiting DEU | AUT 0
NCT03958656 Phase I Anti-SLAMF7 CAR T cells + Cyclophosphamide + Fludarabine Rimiducid T-cells Expressing an Anti-SLAMF7 CAR for Treating Multiple Myeloma Completed USA 0
NCT03984097 Phase I Dexamethasone + Lenalidomide + Mezagitamab Bortezomib + Dexamethasone + Lenalidomide + Mezagitamab A Study to Evaluate Subcutaneous TAK-079 Added to Standard of Care Regimens in Participants With Newly Diagnosed Multiple Myeloma (NDMM) Active, not recruiting USA 0
NCT03989414 Phase Ib/II Bortezomib + CC-92480 + Dexamethasone CC-92480 + Daratumumab + Dexamethasone Carfilzomib + CC-92480 + Dexamethasone A Study to Determine the Recommended Dose and Regimen and Evaluate the Safety and Preliminary Efficacy of CC-92480 in Combination With Standard Treatments in Subjects With Relapsed or Refractory Multiple Myeloma (RRMM) and Newly Diagnosed Multiple Myeloma (NDMM) Active, not recruiting USA | ITA | GRC | FRA | ESP | DNK | DEU | CZE | CAN 0
NCT03992170 Phase II Daratumumab Study of Daratumumab in Multiple Myeloma (MM) Patients in >VGPR/MRD-positive (DART4MM) Unknown status ITA 0
NCT03993912 Phase III Daratumumab + Dexamethasone + Lenalidomide Dexamethasone + Lenalidomide Compare Lenalidomide and Subcutaneous Daratumumab vs Lenalidomide and Dexamethasone in Frail Subjects With Previously Untreated Multiple Myeloma Who Are Ineligible for High Dose Therapy (IFM2017_03) Active, not recruiting FRA 0
NCT03997968 Phase Ib/II CYT01B A Phase 1/2 Study of CYT-0851, an Oral RAD51 Inhibitor, in B-Cell Malignancies and Advanced Solid Tumors Active, not recruiting USA 0
NCT04000282 Phase I SAR442085 First-in-human Single Agent Study of SAR442085 in Relapsed or Refractory Multiple Myeloma Completed USA | GRC | FRA | ESP | CZE 1
NCT04009109 Phase II Daratumumab + Dexamethasone + Ixazomib + Lenalidomide Study of Lenalidomide/Ixazomib/Dexamethasone/Daratumumab in Transplant-Ineligible Patients With Newly Diagnosed MM Active, not recruiting USA 0
NCT04017130 Phase I TAK-169 A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), and Efficacy of TAK-169 in Participants With Relapsed or Refractory Multiple Myeloma (RRMM) Terminated USA 0
NCT04036461 Phase I CC-99712 A Study of CC-99712, a BCMA Antibody-Drug Conjugate, in Subjects With Relapsed and Refractory Multiple Myeloma Terminated USA | ITA | FRA | ESP | CAN 0
NCT04045028 Phase I Tiragolumab Daratumumab + Tiragolumab Rituximab + Tiragolumab A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), Pharmacodynamics (PD), and Preliminary Activity of Tiragolumab in Participants With Relapsed or Refractory Multiple Myeloma or With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma Terminated USA 1
NCT04045795 Phase I Dexamethasone + Isatuximab + Pomalidomide Multi-center, Open-label, Phase 1b Study in Patients With Relapsed/Refractory Multiple Myeloma (RRMM) Completed USA | FRA | ESP | BEL | AUS 1
NCT04052880 Phase II Daratumumab + Ixazomib Bortezomib + Daratumumab + Dexamethasone + Lenalidomide Daratumumab + Lenalidomide Study of SubQ Dara With Dose-Attenuated Bortezomib, Lenalidomide, Dexamethasone in Elderly NDMM Recruiting USA 0
NCT04068597 Phase Ib/II CCS1477 Study to Evaluate CCS1477 in Haematological Malignancies Recruiting USA | SWE | GBR | FRA | ESP 0
NCT04071457 Phase III Daratumumab + Lenalidomide + rHuPH20 Lenalidomide S1803, Daratumumab/rHuPh20 +/- Lenalidomide as Post-ASCT Maintenance for MM w/MRD to Direct Therapy Duration (DRAMMATIC) Recruiting USA | CAN 0
NCT04083534 Phase I REGN5459 First In Human (FIH) Study of REGN5459 in Patients With Relapsed or Refractory Multiple Myeloma (MM) Active, not recruiting USA 0
NCT04083898 Phase Ib/II Bendamustine + Isatuximab + Prednisone Isatuximab, Bendamustine, and Prednisone in Penta-Refractory Multiple Myeloma Terminated USA 0
NCT04091126 Phase III Bortezomib + Dexamethasone + Lenalidomide belantamab mafodotin-blmf + Bortezomib + Dexamethasone + Lenalidomide Bortezomib, Lenalidomide and Dexamethasone (VRd) With Belantamab Mafodotin Versus VRd Alone in Transplant Ineligible Multiple Myeloma Recruiting USA | POL | ITA | GBR | FRA | ESP | DEU | CAN | AUS 1
NCT04093596 Phase I ALLO-647 + ALLO-715 ALLO-647 + ALLO-715 + Cyclophosphamide + Fludarabine Safety and Efficacy of ALLO-715 BCMA Allogenic CAR T Cells in in Adults With Relapsed or Refractory Multiple Myeloma (UNIVERSAL) (UNIVERSAL) Active, not recruiting USA 0
NCT04108195 Phase I Daratumumab + Teclistamab Daratumumab + Talquetamab-tgvs A Study of Subcutaneous Daratumumab Regimens in Combination With Bispecific T Cell Redirection Antibodies for the Treatment of Participants With Multiple Myeloma Active, not recruiting USA | NLD | ESP | DEU | CAN 0
NCT04111107 Phase II Precision Medicine for Patients With Identified Actionable Mutations Terminated USA 0
NCT04113018 Phase II Carfilzomib + Daratumumab + Dexamethasone + Lenalidomide Study of Daratumumab Combined With Carfilzomib, Lenalidomide and Dexamethasone for Newly Diagnosed Multiple Myeloma Active, not recruiting USA 0
NCT04119336 Phase II Cyclophosphamide + Dexamethasone + Ixazomib + Nivolumab Nivolumab, Ixazomib, Cyclophosphamide, and Dexamethasone in Relapsed/Refractory Myeloma Terminated USA 0
NCT04123418 Phase I WVT078 A Study of WVT078 in Patients With Multiple Myeloma (MM) Active, not recruiting USA | NOR | ITA | ISR | ESP | DEU | AUS 1
NCT04126200 Phase II belantamab mafodotin-blmf + Isatuximab belantamab mafodotin-blmf + Dostarlimab-gxly belantamab mafodotin-blmf + GSK3359609 belantamab mafodotin-blmf + Nirogacestat belantamab mafodotin-blmf belantamab mafodotin-blmf + GSK3174998 Platform Study of Belantamab Mafodotin as Monotherapy and in Combination With Anti-cancer Treatments in Participants With Relapsed/Refractory Multiple Myeloma (RRMM) (DREAMM 5) Recruiting USA | SWE | POL | NOR | NLD | ISR | GRC | FRA | ESP | DEU | CAN | BRA | AUS 4
NCT04133636 Phase II Ciltacabtagene autoleucel A Study of JNJ-68284528, a Chimeric Antigen Receptor T Cell (CAR-T) Therapy Directed Against B-cell Maturation Antigen (BCMA) in Participants With Multiple Myeloma (CARTITUDE-2) Recruiting USA | NLD | ISR | FRA | ESP | DEU | BEL 1
NCT04136756 Phase I NKTR-255 Daratumumab + NKTR-255 NKTR-255 in Relapsed/Refractory Multiple Myeloma and Non Hodgkin Lymphoma and Combined With Daratumumab for Multiple Myeloma Completed USA 0
NCT04140162 Phase II Lenalidomide Bortezomib + Daratumumab + Dexamethasone + Lenalidomide Daratumumab + Dexamethasone + Lenalidomide Daratumumab + Lenalidomide Adaptive Strategy in Treatment for Newly Diagnosed Multiple Myeloma With Upfront Daratumumab-based Therapy Active, not recruiting USA 0
NCT04142619 Phase I UCARTCS1A Study Evaluating Safety and Efficacy of UCART Targeting CS1 in Patients With Relapsed/Refractory Multiple Myeloma (MELANI-01) Terminated USA 0
NCT04150692 Phase II Daratumumab Escalation of Daratumumab Frequency Following Biochemical Progression in Relapsed/Refractory Multiple Myeloma Withdrawn 0
NCT04150965 Phase Ib/II Relatlimab BMS-986207 BMS-986207 + Dexamethasone + Pomalidomide Dexamethasone + Pomalidomide + Relatlimab Dexamethasone + Elotuzumab + Pomalidomide Immuno-Oncology Drugs Elotuzumab, Anti-LAG-3 and Anti-TIGIT Active, not recruiting USA 0
NCT04151667 Phase II Daratumumab + Dexamethasone Bortezomib + Daratumumab + Dexamethasone Daratumumab + Dexamethasone + Lenalidomide Daratumumab Based Response Adapted Therapy for Older Adults With Newly Diagnosed Multiple Myeloma Active, not recruiting USA 0
NCT04155749 Phase I CART-ddBCMA ACLX-001 Master Protocol for the Phase 1 Study of Cell Therapies in Multiple Myeloma Active, not recruiting USA 0
NCT04162210 Phase III Dexamethasone + Pomalidomide belantamab mafodotin-blmf Study of Single Agent Belantamab Mafodotin Versus Pomalidomide Plus Low-dose Dexamethasone (Pom/Dex) in Participants With Relapsed/Refractory Multiple Myeloma (RRMM) Active, not recruiting USA | POL | NLD | ITA | HUN | GRC | GBR | FRA | ESP | DEU | CAN | BRA | BGR | BEL | AUS 4
NCT04166565 Phase II Bortezomib + Cyclophosphamide + Daratumumab + Dexamethasone Daratumumab Combined With Bortezomib, Cyclophosphamide and Dexamethasone for the Treatment of Multiple Myeloma Patients Presenting With Extramedullary Disease (EMN19) Active, not recruiting TUR | ITA | GRC 0
NCT04171843 Phase Ib/II Cyclophosphamide + Fludarabine + PBCAR269A Cyclophosphamide + Fludarabine + Nirogacestat + PBCAR269A A Dose-escalation Study to Evaluate the Safety and Clinical Activity of PBCAR269A, With or Without Nirogacestat, in Study Participants With Relapsed/Refractory Multiple Myeloma Terminated USA 0
NCT04176380 Phase II RAPA-201 RAPA-201 T Cell Therapy for Relapsed, Refractory Multiple Myeloma Unknown status USA 0
NCT04176718 Phase II Carfilzomib + Daratumumab + Dexamethasone + Pomalidomide Daratumumab, Carfilzomib, Pomalidomide, Dexamethasone In MM Recruiting USA 0
NCT04178902 Phase I ABBV-467 A Study of the Safety and Tolerability of ABBV-467 in Adult Participants With Relapsed/Refractory Multiple Myeloma Terminated USA | ISR | FRA | ESP | AUS 2
NCT04181827 Phase III Daratumumab + Dexamethasone + Pomalidomide Bortezomib + Dexamethasone + Pomalidomide Bortezomib + Ciltacabtagene autoleucel + Cyclophosphamide + Dexamethasone + Fludarabine + Pomalidomide Ciltacabtagene autoleucel + Cyclophosphamide + Daratumumab + Dexamethasone + Fludarabine + Pomalidomide A Study Comparing JNJ-68284528, a CAR-T Therapy Directed Against B-cell Maturation Antigen (BCMA), Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) or Daratumumab, Pomalidomide and Dexamethasone (DPd) in Participants With Relapsed and Lenalidomide-Refractory Multiple Myeloma (CARTITUDE-4) Active, not recruiting USA | SWE | POL | NLD | ITA | ISR | GRC | GBR | FRA | ESP | DNK | DEU | BEL | AUS 2
NCT04184050 Phase Ib/II HPN217 A Phase 1/2 Open-label, Multicenter, Dose Escalation and Dose Expansion Study of the Safety, Tolerability, and PK of HPN217 in Patients With R/R MM Active, not recruiting USA | FRA | ESP 0
NCT04196491 Phase I Lenalidomide Cyclophosphamide + Fludarabine + Idecabtagene Vicleucel A Study to Evaluate the Safety of bb2121 in Subjects With High Risk, Newly Diagnosed Multiple Myeloma (NDMM) (KarMMa-4) (KarMMa-4) Completed USA 0
NCT04205240 Phase II Cyclophosphamide + Daratumumab + Mycophenolate mofetil + Tacrolimus Fludarabine + Melphalan Reduce Intensity Conditioning Donor Stem Cell Transplant for the Treatment of Relapsed Multiple Myeloma Terminated USA 0
NCT04205409 Phase II Nivolumab Nivolumab for the Treatment of Relapsed or Refractory Hematologic Malignancies Active, not recruiting USA 0
NCT04214093 Phase I AZD0466 A Study of AZD0466 in Patients With Advanced Hematologic or Solid Tumors Terminated USA 0
NCT04223661 Phase II Daratumumab + Dexamethasone + Lenalidomide Frailty Score-guided Dosing of Lenalidomide, Dexamethasone and Daratumumab Induction Therapy Withdrawn USA 0
NCT04240054 Phase II Bortezomib + Cyclophosphamide + Dexamethasone + Isatuximab Bortezomib, Isatuximab, Cyclophosphamide and Dexamethasone Induction in Transplant-Eligible Multiple Myeloma Patients (VICD) Recruiting USA 0
NCT04244656 Phase I CTX120 A Safety and Efficacy Study Evaluating CTX120 in Subjects With Relapsed or Refractory Multiple Myeloma Active, not recruiting USA | ESP | CAN | AUS 0
NCT04246047 Phase III belantamab mafodotin-blmf + Bortezomib + Dexamethasone Bortezomib + Daratumumab + Dexamethasone Evaluation of Efficacy and Safety of Belantamab Mafodotin, Bortezomib and Dexamethasone Versus Daratumumab, Bortezomib and Dexamethasone in Participants With Relapsed/Refractory Multiple Myeloma (DREAMM 7) Active, not recruiting USA | POL | NZL | NLD | ITA | ISR | GRC | GBR | FRA | ESP | DEU | CZE | CAN | BRA | BEL | AUS 4
NCT04258683 Phase II Bortezomib + Cyclophosphamide + Dexamethasone + Pembrolizumab A Study of Pembrolizumab Added to the Standard First-Line Therapy of Cyclophosphamide, Bortezomib, and Dexamethasone (CyBorD) for NDMM NTE Withdrawn CAN 0
NCT04268199 Phase II Bortezomib A Multicentre, Non-Blinded Study Exploring Self-Administration of Chemotherapy in the Home Environment (EASE) Recruiting CAN 0
NCT04268498 Phase II Carfilzomib + Dexamethasone + Lenalidomide Bortezomib + Dexamethasone + Lenalidomide Carfilzomib + Daratumumab + Dexamethasone + Lenalidomide A Study of Daratumumab, Carfilzomib, Lenalidomide, and Dexamethasone in Patients With Newly-Diagnosed Multiple Myeloma Recruiting USA | SWE 0
NCT04280328 Phase I CPI-444 + Daratumumab CPI-444 Study of CPI-444 as a Single Agent and in Combination With Daratumumab in Patients With Relapsed or Refractory Multiple Myeloma Completed USA 0
NCT04283097 Phase I KPG-818 Safety, Tolerability and Pharmacokinetics Study of KPG-818 in Hematological Malignancies Subjects Recruiting USA 0
NCT04287855 Phase II Carfilzomib + Isatuximab + Pomalidomide Multicenter Open Label Phase 2 Study of Isatuximab Plus Pomalidomide and Dexamethasone With Carfilzomib in Relapsed or Refractory Multiple Myeloma Active, not recruiting FRA 0
NCT04302324 Phase II Clarithromycin + Daratumumab + Dexamethasone + Pomalidomide A Phase II Study of Daratumumab, Clarithromycin, Pomalidomide And Dexamethasone (D-ClaPd) In Multiple Myeloma Patients Previously Exposed to Daratumumab Recruiting USA 0
NCT04309084 Phase Ib/II CYNK-001 Natural Killer Cell (CYNK-001) Infusions in Adults With Multiple Myeloma Active, not recruiting USA 0
NCT04318327 Phase I PHE885 BCMA-directed CAR-T Cell Therapy in Adult Patients With Relapsed and/or Refractory Multiple Myeloma Active, not recruiting USA | ISR | AUS 1
NCT04341181 Phase II Atezolizumab Niraparib Erlotinib Axitinib Cobimetinib + Vemurafenib Avelumab Pertuzumab + Trastuzumab Vismodegib Alectinib Ado-trastuzumab emtansine ProTarget - A Danish Nationwide Clinical Trial on Targeted Cancer Treatment Based on Genomic Profiling (ProTarget) Recruiting DNK 0
NCT04352205 Phase II Bortezomib + Daratumumab + Dexamethasone + Lenalidomide Bortezomib + Daratumumab + Dexamethasone + Thalidomide Daratumumab-Based Therapy for the Treatment of Newly Diagnosed Multiple Myeloma With Kidney Failure Terminated USA 0
NCT04361851 Phase II Daratumumab + Pembrolizumab Study of Dara-Pembro for Multiple Myeloma Patients Withdrawn 0
NCT04394650 Phase I Cyclophosphamide + Fludarabine CC-98633 A Study of CC-98633, BCMA-targeted Chimeric Antigen Receptor (CAR) T Cells, in Subjects With Relapsed and/or Refractory Multiple Myeloma Completed USA 0
NCT04398680 Phase I belantamab mafodotin-blmf A Study of Belantamab Mafodotin in Multiple Myeloma Participants With Normal and Impaired Hepatic Function (DREAMM 13) Recruiting USA | GRC 1
NCT04398745 Phase I belantamab mafodotin-blmf A Study of Belantamab Mafodotin Monotherapy in Multiple Myeloma Participants With Normal and Varying Degree of Impaired Renal Function (DREAMM12) Recruiting USA | GRC 2
NCT04401020 Phase I SAR442257 First-in-human Single Agent Study of SAR442257 in RRMM and RR-NHL Active, not recruiting USA | NOR | ESP | CZE 1
NCT04405167 Phase I Tasquinimod Dexamethasone + Ixazomib + Lenalidomide + Tasquinimod Tasquinimod for the Treatment of Relapsed or Refractory Myeloma Recruiting USA 0
NCT04407442 Phase II Azacitidine + Daratumumab + Dexamethasone Daratumumab, Azacitidine, and Dexamethasone for Treatment of Patients With Recurrent or Refractory Multiple Myeloma Previously Treated With Daratumumab Terminated USA 0
NCT04414475 Phase II Bortezomib + Dexamethasone + Selinexor Dexamethasone + Pomalidomide + Selinexor Dexamethasone + Selinexor A Study of Selinexor (Seli) + Low-dose Dexamethasone (LDD) in Penta-refractory Multiple Myeloma (MM), Seli and Bortezomib + LDD in Triple-class Refractory MM, and Seli and Pomalidomide + LDD in Relapsed Refractory MM Recruiting ISR | GRC 0
NCT04430894 Phase II Carfilzomib + Dexamethasone + Isatuximab + Lenalidomide Carfilzomib + Isatuximab + Lenalidomide Lenalidomide KRDI in Transplant-Eligible MM Active, not recruiting USA 0
NCT04445701 Phase Ib/II AO-176 AO-176 + Dexamethasone AO-176 + Bortezomib + Dexamethasone Study of AO-176 as Monotherapy and in Combination With Bortezomib/Dexamethasone in Relapsed/Refractory Multiple Myeloma Completed USA 0
NCT04453397 Expanded access ABBV-383 Expanded Access for TNB-383B in a Subject With Relapsed/Refractory Multiple Myeloma No longer available USA 0
NCT04483739 Phase III Carfilzomib + Dexamethasone + Lenalidomide Carfilzomib + Dexamethasone + Isatuximab + Lenalidomide Isa-KRd vs KRd in Newly Diagnosed Multiple Myeloma Patients Eligible for Autologous Stem Cell Transplantation (IsKia TRIAL) (IsKia) Active, not recruiting NOR | NLD | ITA | GRC | ESP | DEU | CZE 0
NCT04484623 Phase III Bortezomib + Dexamethasone + Pomalidomide belantamab mafodotin-blmf + Dexamethasone + Pomalidomide Belantamab Mafodotin Plus Pomalidomide and Dexamethasone (Pd) Versus Bortezomib Plus Pd in Relapsed/Refractory Multiple Myeloma (DREAMM 8) Recruiting USA | TUR | POL | NZL | ITA | ISR | GRC | GBR | FRA | ESP | DEU | CZE | BRA | AUS 4
NCT04499339 Phase Ib/II Anti-SLAMF7 CAR T cells A Phase I/IIa Clinical Trial to Assess Feasibility, Safety and Antitumor Activity of Autologous SLAMF7 CAR-T Cells in Multiple Myeloma Active, not recruiting FRA | ESP | DEU 0
NCT04505813 Phase Ib/II NEXI-002 T Cells Antigen-specific T Cell Therapy for Patients With Relapsed Refractory Multiple Myeloma Suspended USA 0
NCT04513639 Phase II Carfilzomib + Daratumumab + Dexamethasone The Relapse From MRD Negativity as Indication for Treatment (REMNANT) Study Recruiting NOR 0
NCT04519476 Phase I Lenalidomide + Selinexor Methylprednisolone Selinexor Treatment for Multiple Myeloma Patients Who Are Refractory to Lenalidomide-containing Therapy. Recruiting USA 0
NCT04534322 Expanded access Dexamethasone + Melflufen Expanded Access Program for Melphalan Flufenamide (Melflufen) in Triple Class Refractory Multiple Myeloma (sEAPort) Approved for marketing USA 0
NCT04543305 Phase I PRT1419 A Study of PRT1419 in Patients With Relapsed/Refractory Hematologic Malignancies Completed USA 0
NCT04555551 Phase I MCARH109 MCARH109 Chimeric Antigen Receptor (CAR) Modified T Cells for the Treatment of Multiple Myeloma Active, not recruiting USA 0
NCT04557098 Phase II Teclistamab A Study of Teclistamab, in Participants With Relapsed or Refractory Multiple Myeloma Active, not recruiting USA | SWE | NLD | ITA | GBR | FRA | ESP | DEU | CAN | BEL 1
NCT04557150 Phase I RO7425781 A Study Evaluating the Safety and Pharmacokinetics of Escalating Doses of RO7425781 in Participants With Relapsed or Refractory Multiple Myeloma (r/r MM) Recruiting NZL | ITA | GBR | FRA | ESP | DNK | BRA | BEL | AUS 1
NCT04564703 Phase II Iberdomide Iberdomide (Cc220) Maintenance After Asct in Newly Diagnosed MM Patients Active, not recruiting NLD | ITA | GRC | FRA 0
NCT04566328 Phase III Bortezomib + Daratumumab + Dexamethasone + Lenalidomide Daratumumab + Lenalidomide Daratumumab + Dexamethasone + Lenalidomide Testing the Use of Combination Therapy in Adult Patients With Newly Diagnosed Multiple Myeloma, the EQUATE Trial Recruiting USA 1
NCT04570631 Phase I ABBV-621 + Bortezomib + Dexamethasone Study to Determine Recommended Phase 2 Dose of Intravenous (IV) Eftozanermin Alfa in Combination With IV or Subcutaneous (SC) Bortezomib and Oral Dexamethasone Tablet and to Assess Change in Disease Symptoms in Adult Participants With Relapsed or Refractory Multiple Myeloma Active, not recruiting USA | ITA | FRA | ESP | DEU 1
NCT04586426 Phase I Talquetamab-tgvs + Teclistamab A Study of the Combination of Talquetamab and Teclistamab in Participants With Relapsed or Refractory Multiple Myeloma Recruiting USA | ISR | ESP | CAN | AUS 2
NCT04613557 Phase I CYAD-211 Safety, Activity and Cell Kinetics of CYAD-211 in Patients With Relapsed or Refractory Multiple Myeloma (IMMUNICY-1) Active, not recruiting USA | BEL 0
NCT04614636 Phase I Cyclophosphamide + Fludarabine Daratumumab + FT538 Elotuzumab + FT538 FT538 FT538 in Subjects With Advanced Hematologic Malignancies Terminated USA 0
NCT04634552 Phase II Talquetamab-tgvs A Study of Talquetamab in Participants With Relapsed or Refractory Multiple Myeloma Recruiting USA | POL | NLD | ISR | FRA | ESP | DEU | BEL 3
NCT04635189 Phase II Daratumumab + Dexamethasone + Lenalidomide Daratumumab + Lenalidomide Steroid Sparing Treatment With in Newly Diagnosed Transplant Ineligible Patients With Multiple Myeloma Active, not recruiting USA 0
NCT04635735 Phase Ib/II Ipilimumab Study of Ipilimumab After Stem Cell Transplantation in People With Relapsed/Refractory Multiple Myeloma Terminated USA 0
NCT04643002 Phase Ib/II Dexamethasone + Isatuximab + Pomalidomide Dexamethasone + Isatuximab + SAR439459 Isatuximab in Combination With Novel Agents in RRMM Recruiting USA | NOR | ITA | ISR | GRC | FRA | DEU | AUS 2
NCT04649060 Phase III Daratumumab + Dexamethasone + Melflufen Daratumumab Study of Melphalan Flufenamide (Melflufen) in Combination With Daratumumab in Relapsed Refractory Multiple Myeloma (LIGHTHOUSE) Terminated POL | NOR | GRC | ESP | DEU | CZE | BGR 4
NCT04649359 Phase II Elranatamab-bcmm Study of PF-06863135 Monotherapy in Participants With Multiple Myeloma Who Are Refractory to at Least One PI, One IMiD and One Anti-CD38 mAb Active, not recruiting USA | POL | GBR | FRA | ESP | DEU | CAN | BEL | AUS 1
NCT04653246 Phase II Bortezomib + Dexamethasone + Isatuximab + Lenalidomide Phase 2, Multi-Center, Single-Arm, Open-Label Study to Evaluate the Efficacy and Safety of the Combination Regimen Isatuximab, Lenalidomide, Bortezomib, and Dexamethasone in Patients With Newly Diagnosed Multiple Myeloma Recruiting USA 0
NCT04656951 Phase II Daratumumab Daratumumab for First Line Treatment of Transplant-ineligible Myeloma Patients Followed by Daratumumab Re-treatment at First Relapse (GMMG-DADA) Recruiting DEU 0
NCT04661137 Phase II Dexamethasone + Pomalidomide + Selinexor Daratumumab + Dexamethasone + Selinexor Carfilzomib + Dexamethasone + Selinexor A Study of Selinexor, in Combination With Carfilzomib, Daratumumab or Pomalidomide in Patients With Multiple Myeloma Recruiting USA 0
NCT04674813 Phase I BMS-986393 + Cyclophosphamide + Fludarabine A Study of CC-95266 in Subjects With Relapsed and/or Refractory Multiple Myeloma Active, not recruiting USA 0
NCT04680468 Phase II belantamab mafodotin-blmf Study of Belantamab Mafodotin as Pre- and Post-autologous Stem Cell Transplant and Maintenance for Multiple Myeloma Recruiting USA 0
NCT04684108 Phase I SG301 SG301 Safety Study in Subjects With Relapsed or Refractory Multiple Myeloma and Other Hematological Malignancies Active, not recruiting 1
NCT04688853 Phase I TEG002 A Study to Investigate the Safety and Efficacy of TEG002 in Relapsed/Refractory Multiple Myeloma Patients Unknown status USA 0
NCT04700176 Phase II Daratumumab + Dexamethasone + Pomalidomide + Tretinoin A Study of Daratumumab With Pomalidomide, Dexamethasone, and All-Transretinoic Acid in Patients With Multiple Myeloma Terminated USA 0
NCT04702425 Phase I MIK665 + VOB560 VOB560-MIK665 Combination First in Human Trial in Patients With Hematological Malignancies (Relapsed/Refractory Non-Hodgkin Lymphoma, Relapsed/Refractory Acute Myeloid Leukemia, or Relapsed/Refractory Multiple Myeloma) Terminated USA | ITA | ISR | FIN | ESP | BEL 3
NCT04720313 Phase I NXC-201 NXC-201 (Formerly HBI0101) Multiple Myeloma Recruiting ISR 0
NCT04722146 Phase I Nirogacestat + Teclistamab Daratumumab + Pomalidomide + Teclistamab Bortezomib + Daratumumab + Lenalidomide + Teclistamab A Study of Teclistamab With Other Anticancer Therapies in Participants With Multiple Myeloma Active, not recruiting USA | GBR | FRA | BEL | AUS 0
NCT04735575 Phase Ib/II EMB-06 A Ph1/2 Study of EMB-06 in Participants With Relapsed or Refractory Myeloma Recruiting AUS 1
NCT04751877 Phase III Dexamethasone + Isatuximab + Lenalidomide Bortezomib + Dexamethasone + Isatuximab + Lenalidomide Study of Isatuximab+Lenalidomide+Dexamethasone With/Without Bortezomib in de Novo Non Frail NTE Multiple Myeloma Elderly Patients (IFM2020-05) Active, not recruiting FRA 0
NCT04756401 Phase II Carfilzomib + Daratumumab + Dexamethasone + Selinexor Selinexor, Daratumumab, Carfilzomib and Dexamethasone for the Treatment of High-Risk, Recurrent or Refractory Multiple Myeloma Active, not recruiting USA 0
NCT04756726 Phase Ib/II CFT7455 CFT7455 + Dexamethasone Study to Assess the Safety and Tolerability of CFT7455 in Relapsed/Refractory Non-Hodgkin's Lymphoma or Multiple Myeloma Recruiting USA 0
NCT04758767 Phase I CID-103 CID-103 (Anti-CD38 Antibody) in Previously Treated Relapsed or Refractory Multiple Myeloma Active, not recruiting GBR | FRA 0
NCT04764942 Phase Ib/II Dexamethasone + Pomalidomide + Selinexor Carfilzomib + Dexamethasone + Pomalidomide + Selinexor Selinexor, Pomalidomide, and Dexamethasone With or Without Carfilzomib for the Treatment of Patients With Relapsed Refractory Multiple Myeloma, The SCOPE Trial Recruiting USA 0
NCT04771572 Phase I LP-118 Study of Oral Administration of LP-118 in Patients With Relapsed or Refractory CLL, SLL, MDS, MDS/MPN, AML, CMML-2, MPN-BP, ALL, MF, NHL, RT, MM or T-PLL. Recruiting USA 0
NCT04775550 Phase II Bortezomib + Daratumumab + Dexamethasone + Lenalidomide DARA RVD For High Risk SMM (PRISM) Recruiting USA 0
NCT04776018 Phase Ib/II Mezagitamab + Subasumstat Daratumumab and hyaluronidase-fihj + Subasumstat A Study Of TAK-981 Given With Monoclonal Antibodies In Adults With Relapsed or Refractory Multiple Myeloma Terminated USA | CAN 0
NCT04776395 Phase II Iberdomide Dexamethasone + Iberdomide Iberdomide Alone or in Combination With Dexamethasone for the Treatment of Intermediate- or High-Risk Smoldering Multiple Myeloma Recruiting USA 0
NCT04782687 Phase II Daratumumab + Dexamethasone + Lenalidomide + Selinexor Phase II Study of Selinexor Plus DRd for Newly Diagnosed Multiple Myeloma Recruiting USA 0
NCT04802031 Phase II Isatuximab Rapid-infusion Isatuximab in Relapsed/Refractory Multiple Myeloma Withdrawn 0
NCT04802356 Phase II belantamab mafodotin-blmf + Bortezomib + Dexamethasone + Lenalidomide Belantamab Mafodotin in Newly Diagnosed Transplant Eligible Multiple Myeloma Patients Recruiting ESP 0
NCT04822337 Phase Ib/II belantamab mafodotin-blmf + Carfilzomib + Dexamethasone + Lenalidomide Study of Carfilzomib, Lenalidomide, Dexamethasone and Belantamab Mafodotin in Multiple Myeloma Active, not recruiting USA 0
NCT04824794 Phase Ib/II GEN3014 GEN3014 Safety Trial in Relapsed or Refractory Hematologic Malignancies Active, not recruiting USA | SWE | POL | NZL | NLD | HUN | GRC | FRA | ESP | DNK | CZE | AUS 8
NCT04835129 Phase II Dexamethasone + Elotuzumab + Isatuximab + Pomalidomide Isatuximab, Pomalidomide, Elotuzumab and Dexamethasone in Relapsed and/or Refractory Multiple Myeloma Recruiting USA 0
NCT04843579 Phase II Clarithromycin + Dexamethasone + Pomalidomide + Selinexor Treatment of Selinexor in Combination With Clarithromycin, Pomalidomide and Dexamethasone for Relapsed Refractory Multiple Myeloma Patients (ClaSPd) Terminated USA 0
NCT04850599 Phase II Carfilzomib + Isatuximab + Pomalidomide Isatuximab, Carfilzomib, and Pomalidomide for the Treatment of Relapsed or Refractory Multiple Myeloma Active, not recruiting USA 0
NCT04855136 Phase Ib/II Iberdomide + Idecabtagene Vicleucel Idecabtagene Vicleucel + LY3039478 Bortezomib + Dexamethasone + Idecabtagene Vicleucel + Pomalidomide Safety and Efficacy of bb2121 (Ide-cel) Combinations in Multiple Myeloma (KarMMa-7) Active, not recruiting USA | ESP 0
NCT04855929 Phase Ib/II ANV419 A Study Evaluating Safety and Therapeutic Activity of ANV419 in Patients With Advanced Cancer and Multiple Myeloma. (ANV419-001) Completed GBR | ESP | CHE 0
NCT04864522 Phase I SLAMF7 BATs Pilot Study of SLAMF7 BATs/CS-1 BATs in Relapsed/Refractory Multiple Myeloma (MM BATs) Withdrawn USA 0
NCT04876248 Phase II belantamab mafodotin-blmf + Lenalidomide Belantamab Mafodotin and Lenalidomide for the Treatment of Multiple Myeloma in Patients With Minimal Residual Disease Positive After Stem Cell Transplant Recruiting USA 0
NCT04879043 Phase Ib/II HDP-101 Study to Assess Safety of HDP-101 in Patients With Relapsed Refractory Multiple Myeloma Recruiting USA | POL | HUN | DEU 0
NCT04883242 Phase II Carfilzomib + Dexamethasone + Isatuximab + Pomalidomide Isatuximab, Carfilzomib, Pomalidomide, and Dexamethasone for the Treatment of Relapsed or Refractory Multiple Myeloma Recruiting USA 0
NCT04891809 Phase II Dexamethasone + Isatuximab + Lenalidomide Dexamethasone + Lenalidomide Isatuximab in Combination With Rd Compared to Rd in Elderly Patients (Aged >=70 Years) With NDMM Recruiting GRC | AUT 1
NCT04892264 Phase Ib/II belantamab mafodotin-blmf + Daratumumab + Lenalidomide belantamab mafodotin-blmf + Daratumumab + Dexamethasone + Lenalidomide Belantamab Mafodotin, Lenalidomide, and Daratumumab for the Treatment of Relapsed, Refractory, or Previously Untreated Multiple Myeloma Completed USA 0
NCT04892446 Phase II Dexamethasone + Hu5F9-G4 + Pomalidomide Daratumumab + Hu5F9-G4 Bortezomib + Dexamethasone + Hu5F9-G4 Study of Magrolimab Combinations in Participants With Relapsed/Refractory Multiple Myeloma Completed USA | CZE | CAN 0
NCT04895410 Phase I Lemzoparlimab Dexamethasone + Lemzoparlimab Daratumumab + Dexamethasone + Lemzoparlimab Carfilzomib + Dexamethasone + Lemzoparlimab Dexamethasone + Lemzoparlimab + Pomalidomide Study to Assess Adverse Events and Change in Disease Activity of Intravenous (IV) Lemzoparlimab (TJ011133) With or Without Oral/IV Dexamethasone and in Combination With Oral/IV/Subcutaneous Anti-Myeloma Regimens in Adult Participants With Multiple Myeloma Terminated USA | ISR | FRA | ESP | DEU | AUS 1
NCT04896658 Phase Ib/II belantamab mafodotin-blmf + Cyclophosphamide + Dexamethasone Belantamab Mafodotin, Cyclophosphamide, and Dexamethasone in Relapsed/Refractory Multiple Myeloma Active, not recruiting USA 0
NCT04910568 Phase I Cevostamab + Tocilizumab A Study Evaluating the Safety, Pharmacokinetics, and Activity of Cevostamab in Participants With Relapsed or Refractory Multiple Myeloma Recruiting USA | POL | ITA | ISR | GBR | FRA | ESP | DNK | CZE | CAN | AUS 2
NCT04912427 Phase I Bortezomib + Dexamethasone + Isatuximab satuximab, Velcade, and Dexamethasone in Patients With Multiple Myeloma and Severe KIDNEY Disease Terminated USA 0
NCT04923893 Phase III Dexamethasone + Lenalidomide Ciltacabtagene autoleucel + Cyclophosphamide + Fludarabine Bortezomib + Dexamethasone + Lenalidomide A Study of Bortezomib, Lenalidomide and Dexamethasone (VRd) Followed by Cilta-cel, a CAR-T Therapy Directed Against BCMA Versus VRd Followed by Lenalidomide and Dexamethasone (Rd) Therapy in Participants With Newly Diagnosed Multiple Myeloma for Whom ASCT is Not Planned as Initial Therapy (CARTITUDE-5) Active, not recruiting USA | SWE | POL | NOR | NLD | ISR | IRL | HUN | GRC | GBR | FRA | FIN | ESP | DNK | DEU | CZE | CHE | CAN | BRA | BEL | AUT | AUS | ARG 3
NCT04925193 Phase II Carfilzomib + Dexamethasone + Selinexor Daratumumab + Dexamethasone + Selinexor Dexamethasone + Pomalidomide + Selinexor Personalized Selinexor-based Therapy for Relapsed/Refractory Multiple Myeloma Active, not recruiting USA 0
NCT04933539 Phase II Carfilzomib + Daratumumab + Dexamethasone Subcutaneous Daratumumab, Once Weekly Carfilzomib, and Dexamethasone (DKd) in Patients With High-Risk Smoldering Multiple Myeloma Active, not recruiting USA 0
NCT04934475 Phase III Carfilzomib + Dexamethasone + Isatuximab + Lenalidomide Melphalan MInimal Residual Disease Adapted Strategy (MIDAS) Active, not recruiting FRA | BEL 1
NCT04942067 Phase Ib/II APG-2575 + Dexamethasone + Lenalidomide APG-2575 + Dexamethasone + Pomalidomide APG-2575 + Daratumumab + Dexamethasone + Lenalidomide APG-2575 in Combination With Novel Therapeutic Regimens in Subjects With Relapsed or Refractory Multiple Myeloma Recruiting USA 0
NCT04956302 Phase I Bortezomib + Daratumumab and hyaluronidase-fihj + Dexamethasone + Panobinostat Panobinostat in Combination With Daratumumab, Bortezomib and Dexamethasone for the Treatment of Relapsed/Refractory Multiple Myeloma Terminated USA 0
NCT04960579 Phase I P-BCMA-ALLO1 + Rimiducid P-BCMA-ALLO1 Allogeneic CAR-T Cells in the Treatment of Subjects With Multiple Myeloma (MM) Recruiting USA 0
NCT04973605 Phase Ib/II BGB-11417 + Carfilzomib + Dexamethasone BGB-11417 + Dexamethasone Treatment of Relapsed/Refractory Multiple Myeloma With t 11;14 Translocation Using BGB-11417 With Dexamethasone; Also Using BGB-11417 in Combination With Dexamethasone and Carfilzomib. Recruiting USA | NZL | GBR | CAN | BRA | AUS 2
NCT04975399 Phase I CC-92328 Study to Evaluate the Safety and Tolerability of CC-92328 in Participants With Relapsed and/or Refractory Multiple Myeloma Active, not recruiting USA | ESP | CAN 0
NCT04975555 Phase II Siltuximab Study to Evaluate the Role of Siltuximab in Treatment of Cytokine Release Syndrome (CRS) and Immune Effector Cell Associated Neurotoxicity (ICANS) Related to CAR-T Cell Therapy Recruiting USA 0
NCT04975997 Phase III Bortezomib + Daratumumab + Dexamethasone Daratumumab + Dexamethasone + Iberdomide Open-label Study Comparing Iberdomide, Daratumumab and Dexamethasone (IberDd) Versus Daratumumab, Bortezomib, and Dexamethasone (DVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM). Recruiting USA | TUR | SWE | POL | NOR | NLD | ITA | ISR | IRL | GRC | GBR | FRA | FIN | ESP | DNK | DEU | CZE | CHE | CAN | BRA | BEL | AUT | AUS | ARG 8
NCT04998786 Phase II Dexamethasone + Iberdomide + Ixazomib A Multi-center Open-label Phase 2 Study of Ixazomib, Iberdomide and Dexamethasone in Elderly Patients With Multiple Myeloma at First Relapse." (I2D IFM2021_03) Active, not recruiting FRA 0
NCT05000450 Phase Ib/II ALLO-605 + ALLO-647 + Cyclophosphamide + Fludarabine Safety and Efficacy of ALLO-605 an Anti-BCMA Allogeneic CAR T Cell Therapy in Patients With Relapsed/Refractory Multiple Myeloma Terminated USA 0
NCT05002816 Phase Ib/II belantamab mafodotin-blmf + Elotuzumab Novel Combination of Belantamab Mafodotin and Elotuzumab to Enhance Therapeutic Efficacy in Multiple Myeloma Recruiting USA 0
NCT05005442 Phase II MK-7684A A Study of Pembrolizumab/Vibostolimab (MK-7684A) in Relapsed/Refractory Hematological Malignancies (MK-7684A-004) Active, not recruiting USA | TUR | POL | ITA | ISR | HUN | FRA | ESP | DNK | DEU | CAN | BRA 4
NCT05007418 Phase I STI-1492 Study to Assess Allogeneic Anti-CD38 A2 Dimeric Antigen Receptor T Cells in Relapsed or Refractory Multiple Myeloma Recruiting USA 0
NCT05014412 Phase II Elranatamab-bcmm MagnetisMM-9: Study of Elranatamab (PF-06863135) Monotherapy in Participants With Relapsed/Refractory Multiple Myeloma Active, not recruiting USA | GBR 2
NCT05020236 Phase III Elranatamab-bcmm Daratumumab + Dexamethasone + Pomalidomide Daratumumab + Elranatamab-bcmm MagnetisMM-5: Study of Elranatamab (PF-06863135) Monotherapy and Elranatamab + Daratumumab Versus Daratumumab + Pomalidomide + Dexamethasone in Participants With Relapsed/Refractory Multiple Myeloma (MAGNETISMM-5) Recruiting USA | TUR | SWE | POL | NZL | NOR | NLD | ITA | GRC | GBR | FRA | FIN | ESP | DEU | CZE | CAN | BRA | BEL | AUT | AUS | ARG 5
NCT05027594 Phase I Dexamethasone + NMS-03597812 NMS-03597812 Ph I Study in Adult Patients With Relapsed or Refractory Multiple Myeloma Terminated USA 0
NCT05028348 Phase III Dexamethasone + Elotuzumab + Pomalidomide Dexamethasone + Pomalidomide + Selinexor A Study of Combination of Selinexor, Pomalidomide, and Dexamethasone (SPd) Versus Elotuzumab, Pomalidomide, and Dexamethasone (EloPd) in Subject With Previously Treated Multiple Myeloma Recruiting USA | NLD | ITA | GRC | FRA | ESP | DEU 0
NCT05032820 Phase II Cyclophosphamide + Fludarabine Idecabtagene Vicleucel + Lenalidomide MM CAR-T to Upgrade Response Active, not recruiting USA 0
NCT05050097 Phase I Lenalidomide + Talquetamab-tgvs Daratumumab + Lenalidomide + Talquetamab-tgvs Pomalidomide + Talquetamab-tgvs Carfilzomib + Talquetamab-tgvs Carfilzomib + Daratumumab + Talquetamab-tgvs A Study of Talquetamab With Other Anticancer Therapies in Participants With Multiple Myeloma Active, not recruiting USA | NLD | GBR | FRA | BEL | AUS 0
NCT05060627 Phase Ib/II belantamab mafodotin-blmf + Carfilzomib + Dexamethasone An Open Label, Multicenter, Phase I/II Study of Belantamab Mafodotin in Combination With Kd for the Treatment of Relapsed Myeloma Patients, Refractory to Lenalidomide Recruiting ESP 0
NCT05064358 Phase II belantamab mafodotin-blmf Study to Investigate Alternative Dosing Regimens of Belantamab Mafodotin in Participants With Relapsed or Refractory Multiple Myeloma (DREAMM 14) Active, not recruiting USA | POL | ITA | IRL | GRC | GBR | FRA | ESP | DEU | CHE | CAN | BRA | AUS | ARG 5
NCT05065047 Phase I belantamab mafodotin-blmf Belantamab Mafadotin Maintenance Therapy After Salvage Autologous Hematopoietic Cell Transplantation in Patients With Relapse Refractory Multiple Myeloma Recruiting USA 0
NCT05083169 Phase III Bortezomib + Daratumumab + Dexamethasone Daratumumab + Teclistamab Daratumumab + Dexamethasone + Pomalidomide A Study of Teclistamab in Combination With Daratumumab Subcutaneously (SC) (Tec-Dara) Versus Daratumumab SC, Pomalidomide, and Dexamethasone (DPd) or Daratumumab SC, Bortezomib, and Dexamethasone (DVd) in Participants With Relapsed or Refractory Multiple Myeloma (MajesTEC-3) Active, not recruiting USA | TUR | SWE | POL | NLD | ITA | GRC | GBR | FRA | ESP | DNK | DEU | CAN | BRA | BEL | ARG 5
NCT05090566 Phase II Elranatamab-bcmm + Nirogacestat MagnetisMM-4: Umbrella Study of Elranatamab (PF-06863135) in Combination With Anti-Cancer Treatments in Multiple Myeloma Recruiting USA | CAN 0
NCT05091372 Phase II belantamab mafodotin-blmf Lenalidomide Minimal Residual Disease Guided Maintenance Therapy With Belantamab Mafodotin and Lenalidomide After Autologous Hematopoietic Cell Transplantation in Patients With Newly Diagnosed Multiple Myeloma Recruiting USA 0
NCT05113342 Phase Ib/II Descartes-25 Descartes-25 in Relapsed/Refractory Multiple Myeloma Terminated USA | TUR 0
NCT05117008 Phase II belantamab mafodotin-blmf Maintenance Belantamab Mafodotin (Blenrep) After B-cell Maturation Antigen-Directed Chimeric Antigen Receptor T-cell Therapy in Patients With Relapsed and/or Refractory Multiple Myeloma (EMBRACE) Terminated USA 0
NCT05121103 Phase I EZM0414 A Study in Subjects With Relapsed/Refractory Multiple Myeloma and Relapsed/Refractory Diffuse Large B-Cell Lymphoma Terminated USA 0
NCT05123131 Phase II Bortezomib + Dexamethasone + Isatuximab + Lenalidomide Isa-RVD Study in Patients With Newly Diagnosed Multiple Myeloma (Isa-RVD) Recruiting IRL | DNK 0
NCT05130827 Phase II Plinabulin Study of Plinabulin and Pegfilgrastim in People With Multiple Myeloma Undergoing an Autologous Hematopoietic Stem Cell Transplant (AHCT) Active, not recruiting USA 0
NCT05137054 Phase I Bortezomib + Dexamethasone + Linvoseltamab Carfilzomib + Dexamethasone + Linvoseltamab Dexamethasone + Lenalidomide + Linvoseltamab Daratumumab + Dexamethasone + Linvoseltamab REGN5458 (Anti-BCMA x Anti-CD3 Bispecific Antibody) Plus Other Cancer Treatments for Participants With Relapsed/Refractory Multiple Myeloma Recruiting USA | GRC | FRA | ESP 0
NCT05139225 Phase I Daratumumab + TTI-622 Daratumumab + TTI-621 A Study of TTI-621 and TTI-622 in Combination With Daratumumab Hyaluronidase-fihj in People With Multiple Myeloma Active, not recruiting USA 0
NCT05145400 Phase II Dexamethasone + Isatuximab + Lenalidomide Isa-Rd for Frail and/or Much Older Patients With Newly Diagnosed Multiple Myeloma Recruiting USA 0
NCT05147493 Phase II Bortezomib + Cyclophosphamide + Dexamethasone + Isatuximab Isatuximab + Lenalidomide A Phase 2 Study of Isatuximab in Combination With Bortezomib, Cyclophosphamide and Dexamethasone Followed by Isatuximab and Lenalidomide Maintenance in Newly Diagnosed Patients With Multiple Myeloma and Severe Renal Impairment Not yet recruiting GRC 0
NCT05153330 Phase I BMF-219 Study of BMF-219, a Covalent Menin Inhibitor, in Adult Patients With AML, ALL With KMT2A/ MLL1r, NPM1 and Other Mutations Recruiting USA | NLD | ITA | GRC | ESP 0
NCT05172596 Phase II PHE885 PHE885 CAR-T Therapy in Adult Participants With Relapsed and Refractory Multiple Myeloma Active, not recruiting USA | ITA | ISR | GRC | GBR | FRA | ESP | DEU | CAN | BRA | AUS 3
NCT05177536 Phase II Iberdomide Iberdomide Maintenance Therapy in Patients With Multiple Myeloma Recruiting USA 0
NCT05182073 Phase I Cyclophosphamide + Fludarabine FT576 Daratumumab + FT576 FT576 in Subjects With Multiple Myeloma Active, not recruiting USA 0
NCT05191472 Phase II Pembrolizumab Pembrolizumab for the Treatment of Relapsed or Refractory Multiple Myeloma After Anti-BCMA CAR-T Therapies Terminated USA 0
NCT05199311 Phase Ib/II Carfilzomib + Dexamethasone + Iberdomide Carfilzomib, Iberdomide (CC-220) and Dexamethasone (KID) in Transplant Eligible Multiple Myeloma Recruiting USA 0
NCT05201781 FDA approved Ciltacabtagene autoleucel A Long-term Study for Participants Previously Treated With Ciltacabtagene Autoleucel Recruiting USA | NLD | ISR | FRA | ESP | BEL 2
NCT05204160 Phase II Pembrolizumab Pembrolizumab as Salvage Therapy for the Treatment of Multiple Myeloma in Patients Progressing on CAR-T Cell Therapy Withdrawn USA 0
NCT05205252 Phase Ib/II Lenalidomide + Tafasitamab-cxix + Tazemetostat Daratumumab + Dexamethasone + Pomalidomide + Tazemetostat Daratumumab and hyaluronidase-fihj + Dexamethasone + Pomalidomide + Tazemetostat Mosunetuzumab-axgb + Tazemetostat Lenalidomide + Tazemetostat Acalabrutinib + Tazemetostat A Study of Tazemetostat in Combination With Various Treatments in Participants With Blood Cancer. (ARIA) Withdrawn USA 0
NCT05208307 Phase II belantamab mafodotin-blmf + Dexamethasone + Pomalidomide Belantamab Mafodotin, Pomalidomide and Dexamethasone for the Treatment of High-Risk Myeloma Recruiting USA 0
NCT05227144 Phase I ORIC-533 Study of ORIC-533 in Relapsed or Refractory Multiple Myeloma Active, not recruiting USA | CAN 0
NCT05243342 Phase I Daratumumab + RO7310729 A Study to Evaluate the Safety and Pharmacokinetics of XMAB24306 in Combination With Daratumumab in Participants With Relapsed/Refractory Multiple Myeloma Completed NOR | ESP | DNK | AUS 0
NCT05243797 Phase III Lenalidomide Lenalidomide + Teclistamab A Study of Teclistamab in Combination With Lenalidomide Versus Lenalidomide Alone in Participants With Newly Diagnosed Multiple Myeloma as Maintenance Therapy Following Autologous Stem Cell Transplantation (MajesTEC-4) Recruiting TUR | NOR | NLD | ITA | ISR | IRL | GRC | GBR | FRA | DNK | DEU | CZE | CHE | CAN | BRA | BEL | AUT | AUS 2
NCT05257083 Phase III Ciltacabtagene autoleucel + Cyclophosphamide + Fludarabine Bortezomib + Daratumumab + Dexamethasone + Lenalidomide A Study of Daratumumab, Bortezomib, Lenalidomide and Dexamethasone (DVRd) Followed by Ciltacabtagene Autoleucel Versus Daratumumab, Bortezomib, Lenalidomide and Dexamethasone (DVRd) Followed by Autologous Stem Cell Transplant (ASCT) in Participants With Newly Diagnosed Multiple Myeloma (CARTITUDE-6) Recruiting USA | SWE | NOR | NLD | ITA | ISR | GRC | GBR | FRA | ESP | DEU | CZE | CHE | CAN | BEL | AUS 1
NCT05259839 Phase I ABBV-383 + Dexamethasone + Pomalidomide ABBV-383 + Dexamethasone + Lenalidomide ABBV-383 + Daratumumab + Dexamethasone ABBV-383 + Nirogacestat A Study to Assess Adverse Events and Change in Disease Activity of Intravenously (IV) Infused ABBV-383 in Combination With Anti-Cancer Regimens for the Treatment of Adult Participants With Relapsed/Refractory Multiple Myeloma Recruiting USA | POL | ITA | ESP | DEU | AUS 1
NCT05280275 Phase Ib/II belantamab mafodotin-blmf + Daratumumab + Dexamethasone + Lenalidomide A Study to Investigate the Safety and Clinical Activity of Belantamab Mafodotin in Combination With Daratumumab, Lenalidomide and Dexamethasone in Patients With Newly Diagnosed Multiple Myeloma Transplant Ineligible Recruiting GRC 0
NCT05289492 Phase Ib/II EOS-448 EOS-448 + Iberdomide Dexamethasone + EOS-448 + Iberdomide Study of Novel Regimens in Relapsed or Refractory Multiple Myeloma Terminated USA | FRA | ESP | BEL 0
NCT05293912 Phase I SG2501 SG2501 Safety Study in Subjects With Relapsed or Refractory Hematological Malignancies and Lymphoma. Recruiting USA 0
NCT05298683 Phase II Dexamethasone + Isatuximab + Pomalidomide A Phase 2 Study of Isatuximab in Combination With Pomalidomide and Dexamethasone in MM Patients Who Received One Prior Line of Therapy Containing Lenalidomide and a Proteasome Inhibitor Not yet recruiting GRC 0
NCT05308225 Phase Ib/II STI-6129 Study to Assess Anti-CD38 Antibody Drug Conjugate in Relapsed or Refractory Multiple Myeloma Active, not recruiting USA 0
NCT05308654 Phase I ABBV-453 A Study to Assess the Adverse Events and Change in Disease Activity in Adult Participants With Relapsed or Refractory Multiple Myeloma Receiving Oral ABBV-453 Tablets Active, not recruiting USA | ISR | GBR | AUS 0
NCT05317416 Phase III Lenalidomide Elranatamab-bcmm Study With Elranatamab Versus Lenalidomide in Patients With Newly Diagnosed Multiple Myeloma After Transplant (MagnetisMM-7) Recruiting USA | TUR | SWE | POL | NOR | NLD | ITA | ISR | HUN | GRC | GBR | FRA | FIN | ESP | DEU | CZE | CHE | CAN | BRA | BEL | AUT | AUS 5
NCT05338775 Phase I Talquetamab-tgvs + Teclistamab + unspecified PD-1 antibody A Study of Talquetamab and Teclistamab Each in Combination With a Programmed Cell Death Receptor-1 (PD-1) Inhibitor for the Treatment of Participants With Relapsed or Refractory Multiple Myeloma Active, not recruiting USA | FRA | ESP | DEU 0
NCT05344833 Phase II Isatuximab + Lenalidomide Post-Autologous Transplant Maintenance With Isatuximab and Lenalidomide in Minimal Residual Disease Positive Multiple Myeloma Recruiting USA 0
NCT05346809 Phase II Isatuximab Isatuximab During Stem Cell Collection and Transplant in Patients With Multiple Myeloma and Lymphoma Recruiting USA 0
NCT05347485 Phase II Ciltacabtagene autoleucel Cyclophosphamide + Fludarabine A Study of JNJ-68284528 Out-of-Specification (OOS) for Commercial Release in Participants With Multiple Myeloma Completed USA 0
NCT05354557 Phase II Iberdomide Study of Iberdomide in People With Multiple Myeloma Who Have Had an Autologous Hematopoietic Stem Cell Transplant (AHCT) Recruiting USA 0
NCT05363111 Phase I 225Ac-DOTA-Daratumumab Radioimmunotherapy (111Indium/225Actinium-DOTA-daratumumab) for the Treatment of Relapsed/Refractory Multiple Myeloma Recruiting USA 0
NCT05372354 Phase Ib/II CC-92480 + Dexamethasone + Tazemetostat CC-92480 + Dexamethasone + Trametinib BMS986158 + CC-92480 + Dexamethasone CC-92480 + Dexamethasone A Study to Evaluate Safety, Drug Levels and Effectiveness of CC-92480 (BMS-986348) in Combination With Other Treatments in Participants With Relapsed or Refractory Multiple Myeloma Recruiting USA | NOR | GBR | ESP | CAN 0
NCT05391750 Phase I Tocilizumab + Venetoclax Venetoclax and Tocilizumab for the Treatment of Patients With Relapsed or Refractory t(11;14) Multiple Myeloma Recruiting USA 0
NCT05392946 Phase Ib/II Bortezomib + Daratumumab + Dexamethasone + Iberdomide Iberdomide, Daratumumab, Bortezomib, and Dexamethasone for the Treatment of Newly Diagnosed Multiple Myeloma, IDEAL Study Recruiting USA 0
NCT05396885 Phase II CART-ddBCMA Study of CART-ddBMCA in Relapsed or Refractory Multiple Myeloma (iMMagine-1) Recruiting USA 0
NCT05405166 Phase III Dexamethasone + Isatuximab + Pomalidomide SC Versus IV Isatuximab in Combination With Pomalidomide and Dexamethasone in RRMM Active, not recruiting USA | TUR | SWE | POL | NOR | ITA | HUN | GRC | GBR | FRA | ESP | DEU | CZE | CAN | BRA | AUS | ARG 4
NCT05427812 Phase Ib/II ISB 1442 Phase 1/2 Study of ISB 1442 in Relapsed/Refractory Multiple Myeloma Recruiting USA | AUS 1
NCT05431608 Phase I MCARH109 + MCARH125 A Study of MCARH109 and MCARH125 in People With Multiple Myeloma Recruiting USA 0
NCT05434689 Phase Ib/II Daratumumab + Dexamethasone + Iberdomide Carfilzomib + Daratumumab + Dexamethasone + Iberdomide COMbination Regimens in MM Post AHCT to elimiNate MRD Utilizing IbERdomide (COMMANDER) Recruiting USA 0
NCT05438043 Phase III Daratumumab + Dexamethasone + Lenalidomide Daratumumab + Dexamethasone + Pomalidomide Daratumumab Carfilzomib + Daratumumab + Dexamethasone A Study of Daratumumab Recruiting USA | POL | ITA | GRC | FRA | ESP | DNK | DEU | BEL 4
NCT05455320 Phase III Daratumumab + Dexamethasone + Pomalidomide + Talquetamab-tgvs Daratumumab + Dexamethasone + Talquetamab-tgvs Dexamethasone + Pomalidomide A Study Comparing Talquetamab in Combination With Daratumumab or in Combination With Daratumumab and Pomalidomide Versus Daratumumab in Combination With Pomalidomide and Dexamethasone in Participants With Relapsed or Refractory Multiple Myeloma Recruiting USA | TUR | POL | NLD | ITA | ISR | GRC | GBR | FRA | ESP | DEU | CZE | BRA | BEL 4
NCT05461209 Phase III belantamab mafodotin-blmf Talquetamab-tgvs A Study of Comparing Talquetamab to Belantamab Mafodotin in Participants With Relapsed/Refractory Multiple Myeloma (MonumenTAL-5) Withdrawn USA | POL 0
NCT05462639 Expanded access Elranatamab-bcmm Elranatamab Expanded Access Protocol in Adults With Relapsed/Refractory Multiple Myeloma (MAGNETISMM17) No longer available USA | CAN 0
NCT05463939 Expanded access Teclistamab Teclistamab Expanded Access Treatment Protocol for Relapsed or Refractory Multiple Myeloma Patients Approved for marketing 0
NCT05493618 Phase Ib/II belantamab mafodotin-blmf + Dexamethasone + Pembrolizumab Pembrolizumab, Belantamab and Dexamethasone in Refractory Multiple Myeloma. Withdrawn USA 0
NCT05497804 Phase II Carfilzomib + Daratumumab + Lenalidomide Carfilzomib + Daratumumab + Dexamethasone + Lenalidomide Combination Treatment Therapy Approaches for the Treatment of High-Risk Multiple Myeloma, REACH Trial Recruiting USA 0
NCT05503550 Expanded access Talquetamab-tgvs Pre-Approval Access Single Patient Request for Talquetamab in Relapsed or Refractory Multiple Myeloma No longer available SVN | ISL | BEL 1
NCT05514990 Phase Ib/II Bortezomib + Dexamethasone + Pembrolizumab Bortezomib + Dexamethasone + Pelareorep + Pembrolizumab Standard Doses of Bortezomib and Pembrolizumab With or Without Pelareorep for the Treatment of Relapsed or Refractory Multiple Myeloma, AMBUSH Trial Recruiting USA 0
NCT05519085 Phase III Bortezomib + Dexamethasone + Pomalidomide Bortezomib + CC-92480 + Dexamethasone A Study to Evaluate CC-92480, Bortezomib and Dexamethasone (480Vd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM) (Successor-1) Recruiting USA | TUR | ROU | POL | NZL | ITA | ISR | IRL | GRC | GBR | FRA | FIN | ESP | DEU | CZE | CAN | BRA | BEL | AUT | AUS | ARG 7
NCT05527340 Phase II Daratumumab + Dexamethasone + Iberdomide Dexamethasone + Iberdomide Iberdomide-dexamethasone Alone or in Combination With Standard MM Treatment Regimens in Transplant Ineligible Newly Diagnosed Patients. Not yet recruiting ESP 0
NCT05530421 Phase II Dexamethasone + Selinexor + Venetoclax Selinexor, Venetoclax, and Dexamethasone (XVenD) in t(11;14)-Positive Relapsed/Refractory Multiple Myeloma (SELVEDge) Recruiting USA 0
NCT05535244 Phase Ib/II Cevostamab + Tocilizumab A Study Evaluating the Efficacy and Safety of Cevostamab in Prior B Cell Maturation Antigen (BCMA)-Exposed Participants With Relapsed/Refractory Multiple Myeloma (CAMMA 2) Recruiting USA | ITA | ISR | FRA | ESP | DEU | BEL | AUS 0
NCT05546723 Phase I LMY-920 LMY-920 for Treatment of Relapsed or Refractory Myeloma (LMY-920-002) Recruiting USA 0
NCT05552222 Phase III Daratumumab + Dexamethasone + Lenalidomide Daratumumab + Lenalidomide + Teclistamab A Study to Compare Teclistamab in Combination With Daratumumab and Lenalidomide (Tec-DR) in Participants With Newly Diagnosed Multiple Myeloma (MajesTEC-7) Recruiting TUR | SWE | POL | NOR | NLD | ITA | ISR | GRC | GBR | FRA | ESP | DNK | DEU | CZE | CHE | CAN | BRA | BEL | AUT | AUS 4
NCT05552976 Phase III Carfilzomib + Dexamethasone Carfilzomib + CC-92480 + Dexamethasone A Study to Evaluate CC-92480 in Combination With Carfilzomib and Dexamethasone (480Kd) Versus Carfilzomib and Dexamethasone (Kd) in Participants With Relapsed or Refractory Multiple Myeloma (SUCCESSOR-2) (SUCCESSOR-2) Recruiting USA | ROU | NOR | NLD | ITA | ISR | HUN | GRC | GBR | ESP | DNK | DEU | CAN | BRA | BGR | AUT | AUS | ARG 9
NCT05556616 Phase I Lenalidomide + TAK-573 Pomalidomide + TAK-573 Bortezomib + TAK-573 Carfilzomib + TAK-573 Bortezomib + Pomalidomide + TAK-573 Carfilzomib + Pomalidomide + TAK-573 Carfilzomib + Daratumumab + TAK-573 Daratumumab + Pomalidomide + TAK-573 A Study of Modakafusp Alfa in Adult Participants With Multiple Myeloma Completed USA | ISR | ESP | BEL 0
NCT05556798 Phase I belantamab mafodotin-blmf + Nirogacestat A Study of Belantamab Mafodotin and Nirogacestat in People With Multiple Myeloma That Has Not Responded to Treatment or Has Come Back After Treatment Active, not recruiting USA 0
NCT05558319 Phase III Bortezomib + Dexamethasone + Iberdomide + Isatuximab + Lenalidomide Bortezomib + Dexamethasone + Isatuximab + Lenalidomide Bortezomib + Dexamethasone + Iberdomide + Isatuximab NDMM Patients Candidates for ASCT Comparing Extended VRD Plus vs. Isa-VRD vs. Isa-V-Iberdomide (GEM21menos65) Not yet recruiting ESP 0
NCT05560399 Phase I Dexamethasone + Elotuzumab + Iberdomide A Study of Iberdomide (CC-220) in Combination With Elotuzumab and Dexamethasone for Relapsed/Refractory Multiple Myeloma (CC-220) Recruiting USA 0
NCT05561387 Phase III Daratumumab and hyaluronidase-fihj + Dexamethasone + Lenalidomide Bortezomib + Dexamethasone + Lenalidomide Daratumumab and hyaluronidase-fihj Lenalidomide Comparing Combinations of Drugs to Treat Newly Diagnosed Multiple Myeloma (NDMM) When a Stem Cell Transplant is Not a Medically Suitable Treatment Recruiting USA 0
NCT05572229 Phase II Lenalidomide + Teclistamab Daratumumab + Teclistamab Study of Teclistamab in Combination in Elderly Patients With Multiple Myeloma (IFM2021-01) Recruiting FRA 0
NCT05572515 Phase III Teclistamab Carfilzomib + Dexamethasone Bortezomib + Dexamethasone + Pomalidomide A Study Comparing Teclistamab Monotherapy Versus Pomalidomide, Bortezomib, Dexamethasone (PVd) or Carfilzomib, Dexamethasone (Kd) in Participants With Relapsed or Refractory Multiple Myeloma (MajesTEC-9) Recruiting USA | TUR | SWE | POL | NLD | ITA | ISR | GRC | GBR | FRA | ESP | DNK | DEU | CZE | CAN | BRA | BEL | AUT | AUS 5
NCT05573802 Phase Ib/II belantamab mafodotin-blmf + Dexamethasone + Lenalidomide + Nirogacestat A Study to Investigate Safety and Clinical Activity of Belantamab Mafodotin in Combination With Lenalidomide, Dexamethasone and Nirogacestat in Patients With Transplant Ineligible Newly Diagnosed Multiple Myeloma Recruiting GRC 0
NCT05577000 Phase I Anti-BCMA CAR-T cells + Cyclophosphamide + Fludarabine Anti-BCMA Chimeric Antigen Receptor T Cells for Relapsed or Refractory Multiple Myeloma Active, not recruiting USA 0
NCT05583617 Phase Ib/II Cevostamab + Lenalidomide + Tocilizumab A Study Evaluating the Safety and Efficacy of Multiple Treatment Combinations in Participants With Multiple Myeloma (PLYCOM) Recruiting POL | FRA | ESP | AUS 1
NCT05590377 Phase Ib/II Daratumumab + TAK-573 A Study of Modakafusp Alfa Together With Daratumumab Adults With Relapsed or Refractory Multiple Myeloma Completed USA | FRA | ESP | CAN | AUS 2
NCT05623020 Phase III Daratumumab + Elranatamab-bcmm + Lenalidomide Daratumumab + Dexamethasone + Lenalidomide A Study to Learn About the Effects of the Combination of Elranatamab (PF-06863135), Daratumumab, and Lenalidomide Compared With Daratumumab, Lenalidomide, and Dexamethasone in Patients With Newly Diagnosed Multiple Myeloma Who Are Not Candidates for Transplant (MagnetisMM-6) Recruiting POL | NLD | ITA | ISR | GRC | FRA | ESP | DEU | CZE | CAN | AUS 3
NCT05641324 Phase I ANV419 + Dexamethasone + Lenalidomide ANV419 + Daratumumab ANV419 A Study of ANV419 Alone or in Combination With Approved Treatments in Patients With Multiple Myeloma (OMNIA-2) Terminated FRA | ESP | DNK | DEU | CHE 0
NCT05646836 Phase I Cevostamab + Tocilizumab Cevostamab + RO7310729 + Tocilizumab A Study to Evaluate the Safety, Pharmacokinetics, and Activity of XmAb24306 in Combination With Cevostamab in Participants With Relapsed/Refractory Multiple Myeloma Recruiting NOR | ISR | GRC | ESP | DNK | AUS 1
NCT05650632 Phase I ABBV-383 A Study to Assess Adverse Events of Intravenously (IV) Infused ABBV-383 in Adult Participants With Relapsed or Refractory Multiple Myeloma Recruiting USA | ISR | GBR | FRA | ESP | DNK | CAN 0
NCT05651932 Phase I KTX-1001 A Study of an MMSET Inhibitor in Patients With Relapsed and Refractory Multiple Myeloma Recruiting USA | FRA | ESP | CAN 0
NCT05652335 Phase I JNJ-79635322 A Study of JNJ-79635322 in Participants With Relapsed or Refractory Multiple Myeloma Recruiting USA | NLD | GBR | FRA | ESP | BEL 1
NCT05665140 Phase II Lenalidomide Isatuximab Bortezomib + Dexamethasone + Lenalidomide Expression-linked and R-ISS-adapted Stratification for First Line Therapy in Multiple Myeloma Patients (ELIAS) Recruiting DEU 0
NCT05666700 Phase I Ciltacabtagene autoleucel CAR-T Cell Therapy in RelApsed/Refractory Myeloma With ExtrameduLlary Disease - an in Vivo Imaging and Molecular Monitoring Study (CARAMEL) Recruiting AUS 0
NCT05675319 Phase III Bortezomib + Daratumumab + Dexamethasone Carfilzomib + Dexamethasone + Lenalidomide belantamab mafodotin-blmf + Daratumumab + Dexamethasone + Lenalidomide Dexamethasone + Elotuzumab + Lenalidomide Bortezomib + Dexamethasone + Pomalidomide Dexamethasone + Ixazomib + Lenalidomide Carfilzomib + Daratumumab + Dexamethasone Allogeneic Stem Cell Transplantation vs. Conventional Therapy as Salvage Therapy for Relapsed / Progressive Patients With Multiple Myeloma After First-line Therapy (AlloRelapseMM) Recruiting DEU 0
NCT05675449 Phase I Carfilzomib + Elranatamab-bcmm A Clinical Trial of Three Medicines (Elranatamab Plus Carfilzomib and Dexamethasone) in People With Relapsed Refractory Multiple Myeloma (MagnetisMM-20) Recruiting USA | ISR 0
NCT05690984 Phase II Dexamethasone + Isatuximab + Lenalidomide Elimination of Minimal Residual Disease After Transplant (EMAT) Recruiting USA 0
NCT05695508 Phase II Daratumumab + Dexamethasone + Lenalidomide + Teclistamab Daratumumab + Lenalidomide + Teclistamab Bortezomib + Daratumumab + Dexamethasone + Lenalidomide + Teclistamab GMMG-HD10 / DSMM-XX / 64007957MMY2003, MajesTEC-5 (HD10/DSMMXX) Recruiting DEU 0
NCT05698303 Phase I CT103A A Study of Fully Human BCMA Chimeric Antigen Receptor Autologous T Cell Injection (CT103A) in the Treatment of Patients With Relapsed/Refractory Multiple Myeloma Not yet recruiting USA 0
NCT05698888 Phase I VP301 Study of VP301 in Patients With Multiple Myeloma, Lymphoma, or Solid Tumors Terminated USA 0
NCT05704049 Phase II Carfilzomib + Dexamethasone + Isatuximab A Study to Investigate Subcutaneous Isatuximab in Combination With Carfilzomib and Dexamethasone in Adult Participants With Relapsed and/or Refractory Multiple Myeloma Active, not recruiting GRC | CZE | BRA | AUS 2
NCT05714839 Phase I Belantamab Belantamab + belantamab mafodotin-blmf + Dexamethasone + Lenalidomide belantamab mafodotin-blmf A Study to Investigate the Safety and Efficacy of Belantamab for the Treatment of Multiple Myeloma When Used as Monotherapy and in Combination Treatments (DREAMM-20) Recruiting TUR | POL | GBR | BRA | AUS | ARG 3
NCT05722418 Phase I CB-011 CRISPR-Edited Allogeneic Anti-BCMA CAR-T Cell Therapy in Patients With Relapsed/Refractory Multiple Myeloma (CaMMouflage) Recruiting USA 0
NCT05730036 Phase III Linvoseltamab Dexamethasone + Elotuzumab + Pomalidomide A Study to Learn How Linvoseltamab (REGN5458) Will Work Compared to the Elotuzumab, Pomalidomide and Dexamethasone (EPd) Combination, in Participants With Relapsed/Refractory Multiple Myeloma (LINKER-MM3) Recruiting USA | POL | NLD | ITA | ISR | GBR | FRA | ESP | DEU | CAN | BRA | BEL | AUS 4
NCT05776979 Phase II Isatuximab + Lenalidomide Post-Transplant Maintenance Therapy With Isatuximab Plus Lenalidomide for High-Risk Multiple Myeloma Patients Recruiting USA 0
NCT05789303 Phase II belantamab mafodotin-blmf + Carfilzomib + Dexamethasone + Pomalidomide Study of Belantamab Mafodotin With Carfilzomib, Pomalidomide, and Dexamethasone in Relapsed Multiple Myeloma Recruiting USA 0
NCT05801939 Phase II Cevostamab Cevostamab Following CAR T Cell Therapy for RRMM Recruiting USA 0
NCT05804032 Phase III Bortezomib + Dexamethasone + Isatuximab + Lenalidomide Lenalidomide, Bortezomib and Dexamethasone Induction Therapy With Either Intravenous or Subcutaneous Isatuximab in Patients With Newly Diagnosed Multiple Myeloma Recruiting DEU | AUT 0
NCT05820763 Phase II Dexamethasone + Lenalidomide + Selinexor Lenalidomide + Selinexor Selinexor and Lenalidomide for Consolidation and Maintenance Treatment in Multiple Myeloma Post-transplant Withdrawn 0
NCT05823571 Phase I Itacitinib Itacitinib With High-dose Posttransplantation Cyclophosphamide in Older Patients Recruiting USA 0
NCT05827016 Phase III Lenalidomide Iberdomide A Study to Compare Iberdomide Maintenance Versus Lenalidomide Maintenance Therapy Following Autologous Stem Cell Transplant in Participants With Newly Diagnosed Multiple Myeloma Recruiting USA | TUR | SWE | ROU | POL | NLD | ITA | ISR | HUN | GRC | GBR | FRA | FIN | ESP | DNK | DEU | CZE | CHE | CAN | BRA | BEL | AUT | AUS | ARG 11
NCT05828511 Phase Ib/II Linvoseltamab A Window of Opportunity Trial to Learn if Linvoseltamab is Safe and Well Tolerated, and How Well it Works in Participants With Recently Diagnosed Multiple Myeloma Who Have Not Already Received Treatment. (LINKER-MM4) Recruiting USA | FRA | ESP 0
NCT05839626 Phase Ib/II SAR445514 A Study to Investigate Safety and Efficacy With SAR445514 in Participants With Relapsed/Refractory Multiple Myeloma (RRMM) and Relapsed/Refractory Light-chain Amyloidosis (RRLCA) Recruiting ITA | HUN | GBR | ESP | CZE | BEL | AUS 0
NCT05841550 Phase Ib/II QS21 + TG01 The TG01 Study With TG01/QS-21 Vaccine in Patients With High-risk Smouldering Multiple Myeloma and Multiple Myeloma Recruiting NOR 0
NCT05847569 Phase II belantamab mafodotin-blmf Alternate Doses and Dosing Schedules of Belantamab Mafodotin for the Treatment of Triple-Class Recurrent and/or Refractory Multiple Myeloma Recruiting USA 0
NCT05849610 Phase II Bortezomib + Daratumumab + Dexamethasone + Lenalidomide Daratumumab + Teclistamab Daratumumab + Talquetamab-tgvs Teclistamab-Daratumumab and Talquestamab-Daratumumab in Newly Diagnosed High-risk Multiple Myeloma (GEM-TECTAL) Recruiting ESP 0
NCT05850234 Phase Ib/II GC012F A Study of GC012F, a CAR T Therapy Targeting CD19 and BCMA in Subjects With Relapsed/Refractory Multiple Myeloma Recruiting USA 0
NCT05853965 Phase Ib/II belantamab mafodotin-blmf + Venetoclax Combination Treatment of Belantamab Mafodotin and Venetoclax in Treatment of Relapsed and Refractory t(11;14) Multiple Myeloma (BELI(E)VE) Recruiting DEU 0
NCT05862012 Phase I ISB 2001 Study of ISB 2001 in Relapsed/Refractory Multiple Myeloma Recruiting USA | AUS 1
NCT05874193 Phase II belantamab mafodotin-blmf A Collaborative Community Effort Using Belantamab Mafodotin in Relapsed Refractory Myeloma (COSTA) Not yet recruiting USA 0
NCT05889221 Phase II Bortezomib + Dexamethasone + Isatuximab + Lenalidomide Multicenter Phase 2 Study of Subcutaneous Isatuximab Plus Bortezomib, Lenalidomide and Dexamethasone in the Treatment of Newly Diagnosed Transplant Ineligible Multiple Myeloma Active, not recruiting FRA 0
NCT05896228 Phase II Iberdomide Carfilzomib + Daratumumab + Dexamethasone + Iberdomide Iberdomide, Daratumumab, Carfilzomib, and Dexamethasone (Iber-KDd) in Patients With Relapsed/Refractory Multiple Myeloma (Iber-KDd) Recruiting USA 0
NCT05908396 Phase I IGM-2644 Evaluation of IGM-2644 in Adults With Relapsed and/or Refractory Multiple Myeloma Terminated USA 0
NCT05908409 Phase Ib/II IDP-121 A Phase 1/2 Study of IDP-121 in Patients With Relapsed/Refractory Hematologic Malignancies Recruiting ESP 0
NCT05911321 Phase II Dexamethasone + Isatuximab + Pomalidomide Isa-Pom-Dex in Elderly/Frail Subjects With RRMM Recruiting USA 0
NCT05918250 Phase I mRNA-2736 mRNA-2736 for Participants With Relapsed or Refractory Multiple Myeloma (RRMM) Withdrawn USA | CAN 0
NCT05922501 Phase II belantamab mafodotin-blmf + Dexamethasone + Isatuximab + Pomalidomide Isatuximab, Bela Maf, Pom, and Dex in Relapsed/Refractory Multiple Myeloma (ISABELA) Not yet recruiting USA 0
NCT05927571 Phase I Cevostamab + Elranatamab-bcmm Tocilizumab A Study Evaluating the Safety, Pharmacokinetics, and Activity of the Combination of Cevostamab and Elranatamab in Participants With Relapsed or Refractory Multiple Myeloma (R/R MM) Recruiting ISR | AUS 1
NCT05972135 Phase II Teclistamab + Tocilizumab Outpatient Administration of Teclistamab for Multiple Myeloma Recruiting USA 0
NCT05981209 Phase I CC-92480 + Dexamethasone + Elotuzumab Elotuzumab, CC-92480, and Dexamethasone for the Treatment of Relapsed or Refractory Myeloma After CD38- and BCMA-Targeted Therapies Recruiting USA 0
NCT06042725 Phase I Daratumumab + Dexamethasone + Lenalidomide + Venetoclax Daratumumab + Dexamethasone + Venetoclax Dexamethasone + Lenalidomide + Venetoclax Venetoclax in Combination With Lenalidomide and Dexamethasone (Ven-Rd), Daratumumab and Dexamethasone (Ven-Dd), or Daratumumab-Lenalidomide-Dexamethasone (Ven-DRd) for the Treatment of Multiple Myeloma Recruiting USA 0
NCT06045806 Phase III Idecabtagene Vicleucel + Lenalidomide Cyclophosphamide + Fludarabine A Study to Compare the Efficacy and Safety of Idecabtagene Vicleucel With Lenalidomide Maintenance Therapy Versus Lenalidomide Maintenance Therapy Alone in Adult Participants With Newly Diagnosed Multiple Myeloma Who Have Suboptimal Response After Autologous Stem Cell Transplantation (KarMMa-9) Active, not recruiting USA | ROU | POL | NOR | ITA | ISR | GRC | GBR | FRA | ESP | DNK | DEU | CZE | CAN | BEL | AUT | AUS 2
NCT06048250 Phase I CC-92480 Mezigdomide (CC-92480) Post Idecabtagene Vicleucel in Treating Patients With Relapsed Multiple Myeloma Recruiting USA 0
NCT06050512 Phase Ib/II CC-92480 + Dexamethasone + Ixazomib Mezigdomide Plus Ixazomib and Dexamethasone for Relapsed and Refractory Multiple Myeloma Recruiting 0
NCT06055075 Phase I Carfilzomib + RO7425781 Daratumumab + RO7425781 RO7425781 A Study Evaluating Safety, Tolerability, and Clinical Activity of Forimtamig-Based Treatment Combinations in Participants With Relapsed or Refractory Multiple Myeloma Recruiting USA | NZL | ITA | FRA | ESP | DNK | DEU | CAN | BRA | AUS 1
NCT06057402 FDA approved Elranatamab-bcmm Elranatamab Post Trial Access Study for Participants With Multiple Myeloma (MM) (MagnetisMM15) Recruiting USA | FRA | CAN | AUS 1
NCT06066346 Phase II Talquetamab-tgvs A Study of Talquetamab for People With Multiple Myeloma Who Have Received BCMA CAR T-Cell Therapy Recruiting USA 0
NCT06066359 Phase Ib/II Cyclophosphamide + Fludarabine + NY-ESO-1 TCR/IL-15 NK Phase I/II Trial of Cord Blood-Derived NK Cells Genetically Engineered With NY-ESO-1 TCR/IL-15 Cell Receptor for Relapsed/Refractory Multiple Myeloma Recruiting USA 0
NCT06083207 Phase Ib/II IBI3003 A Study of IBI3003 in Subjects With Relapsed or Refractory Multiple Myeloma Recruiting AUS 1
NCT06087653 Phase Ib/II Bortezomib + Dexamethasone + Lenalidomide Safety, Efficacy, and Pharmacokinetics of Continuous Subcutaneous Lenalidomide in Multiple Myeloma (MM) Recruiting USA 0
NCT06105554 Phase Ib/II Belumosudil mesylate Phase I/II Open Label Study of Belumosudil Mesylate Alone, and in Combination With Dexamethasone, in Patients With Relapsed/Refractory Multiple Myeloma Recruiting USA 0
NCT06106945 Phase Ib/II AZD0305 A Phase I/II Study of AZD0305 for Relapsed/Refractory Multiple Myeloma Recruiting USA | FRA | ESP | DEU | CAN | AUS 2
NCT06107738 Phase II Daratumumab + Iberdomide Iberdomide and Daratumumab as Maintenance Therapy After an Autologous Stem Cell Transplant for Multiple Myeloma (IBEX) Recruiting USA 0
NCT06119685 Phase Ib/II IDP-023 Cyclophosphamide + Fludarabine Daratumumab + IDP-023 Aldesleukin + IDP-023 IDP-023 + Rituximab IDP-023 as a Single Agent and in Combination With Antibody Therapies in Patients With Advanced Hematologic Cancers Recruiting USA 0
NCT06121843 Phase I BMS-986393 + Iberdomide BMS-986393 + CC-92480 BMS-986393 + CC-93269 A Study to Evaluate the Safety, Effectiveness and Tolerable Dose of BMS-986393 in Novel Combinations in Participants With Relapsed and/or Refractory Multiple Myeloma Recruiting USA | CAN 0
NCT06138275 Phase II Elranatamab-bcmm Elranatamab in R/R Multiple Myeloma Recruiting USA 0
NCT06152575 Phase III Dexamethasone + Elotuzumab + Pomalidomide Carfilzomib + Dexamethasone Bortezomib + Dexamethasone + Pomalidomide Elranatamab-bcmm MagnetisMM-32: A Study to Learn About the Study Medicine Called Elranatamab in People With Multiple Myeloma (MM) That Has Come Back After Taking Other Treatments (Including Prior Treatment With an Anti-CD38 Antibody and Lenalidomide) Recruiting USA | SWE | NOR | NLD | ITA | GRC | GBR | FRA | FIN | ESP | DNK | DEU | CZE | CAN | BRA | BEL | ARG 1
NCT06153251 Phase I BMS-986453 Cyclophosphamide + Fludarabine A Study to Assess BMS-986453 in Participants With Relapsed and/or Refractory Multiple Myeloma Recruiting USA | FRA | ESP | DEU 0
NCT06158841 Phase III Dexamethasone + Elotuzumab + Pomalidomide Carfilzomib + Dexamethasone Bortezomib + Dexamethasone + Selinexor ABBV-383 Study Assessing Activity of Intravenous (IV) ABBV-383 Monotherapy Versus Standard Available Therapies in Adult Participants With Relapsed or Refractory Multiple Myeloma Recruiting USA | SWE | POL | ITA | ISR | HUN | GRC | FRA | ESP | DNK | DEU | BEL | AUT | AUS 6
NCT06163898 Phase Ib/II CC-93269 CC-92480 + CC-93269 + Dexamethasone A Study to Evaluate Alnuctamab in Combination With Mezigdomide in Participants With Relapsed and/or Refractory Multiple Myeloma Active, not recruiting USA | ISR 0
NCT06169215 Phase II Bortezomib + Daratumumab and hyaluronidase-fihj + Dexamethasone + Lenalidomide Bortezomib + Daratumumab + Dexamethasone + Lenalidomide Daratumumab and hyaluronidase-fihj Bortezomib + Daratumumab + Dexamethasone + Selinexor Bortezomib + Daratumumab and hyaluronidase-fihj + Dexamethasone + Selinexor Comparing the Combination of Selinexor-Daratumumab-Velcade-Dexamethasone (Dara-SVD) With the Usual Treatment (Dara-RVD) for High-Risk Newly Diagnosed Multiple Myeloma Recruiting USA 0
NCT06171685 Phase II Teclistamab MMRC Horizon One Adaptive Platform Trial Evaluating Therapies in RRMM Recruiting USA 0
NCT06179888 Phase II Iberdomide Iberdomide Versus Observation Off Therapy After Idecabtagene Vicleucel CAR-T for Multiple Myeloma Recruiting USA 0
NCT06182774 Phase III Dexamethasone + Lenalidomide Daratumumab + Dexamethasone + Lenalidomide Fixed Duration vs Continuous Daratumumab in Transplant Ineligible Older Adults With Newly Diagnosed Multiple Myeloma Recruiting CAN 0
NCT06187441 Phase III Daratumumab + Dexamethasone + Lenalidomide FeAsiBility of a Treatment Free Interval in Newly Diagnosed MM Patients Treated With Daratumumab-lenalidomide-dexamethasone (HOVON174MM) (HOVON174MM) Recruiting NLD 0
NCT06189833 Phase II Bortezomib + Daratumumab + Dexamethasone + Lenalidomide Phase 2 Study Applying MRD Techniques for Participants With Previously Untreated Multiple Myeloma Treated With D-VRd Prior To and After High-dose Therapy Followed by ASCT - TAURUS (TAURUS) Recruiting NLD | ITA | GRC | DEU | AUT 0
NCT06203912 Phase I Cyclophosphamide Dexamethasone Isatuximab + TGF-beta-imprinted NK cells Donor Immune Cells (TGFbi NK Cells) and Isatuximab for the Treatment of Relapsed or Refractory Multiple Myeloma Recruiting USA 0
NCT06207799 Phase II Elranatamab-bcmm Pre-transplant Purging and Post-transplant MRD-guided Maintenance Therapy With Elranatamab in Patients With High-risk Multiple Myeloma Recruiting USA 0
NCT06208150 Phase III Dexamethasone + Elotuzumab + Pomalidomide Bortezomib + Dexamethasone + Pomalidomide Talquetamab-tgvs + Teclistamab Pomalidomide + Talquetamab-tgvs Dexamethasone A Study Comparing Talquetamab Plus Pomalidomide, Talquetamab Plus Teclistamab, and Elotuzumab, Pomalidomide, and Dexamethasone or Pomalidomide, Bortezomib, and Dexamethasone in Participants With Relapsed or Refractory Myeloma Who Have Received an Anti-CD38 Antibody and Lenalidomide (MonumenTAL-6) Recruiting USA | TUR | SWE | POL | NLD | ITA | ISR | HUN | GRC | GBR | FRA | ESP | DNK | DEU | CZE | CAN | BRA | BEL | AUT | AUS | ARG 5
NCT06215118 Phase I Elranatamab-bcmm + Iberdomide A Study to Learn About the Effects of the Combination of Elranatamab (PF-06863135) and Iberdomide in Patients With Relapsed or Refractory Multiple Myeloma (MagnetisMM-30) Recruiting USA | CAN 0
NCT06216158 Phase III Iberdomide Iberdomide + Isatuximab Dexamethasone Iberdomide vs. Iberdomide Plus Isatuximab Maintenance Therapy Post ASCT in Newly Diagnosed Multiple Myeloma Recruiting DEU 0
NCT06223516 Phase I ABBV-383 Study of ABBV-383 Assessing Adverse Events and Clinical Activity With Subcutaneous (SC) Injection in Adult Participants With Relapsed or Refractory Multiple Myeloma Recruiting USA | ISR | DEU 1
NCT06232707 Phase III Carfilzomib Pomalidomide Elotuzumab Dexamethasone Daratumumab CC-93269 A Study to Evaluate Efficacy and Safety of Alnuctamab Compared to Standard of Care Regimens in Participants With Relapsed or Refractory Multiple Myeloma (RRMM) (ALUMMINATE) Withdrawn USA | TUR | SWE | ROU | NOR | ITA | IRL | HUN | GRC | GBR | FRA | ESP | DEU | CZE | CHE | CAN | BRA | BEL | AUT | AUS | ARG 6
NCT06271252 Phase I OriCAR-017 A Study to Evaluate the Safety, PK/PD of (OriCAR-017) in Subjects With RR/MM - RIGEL Study Recruiting USA 0
NCT06282978 Phase II Elranatamab-bcmm Phase II Study of Elranatamab as Single Agent for Relapsed or Refractory Myeloma in Patients Previously Exposed to Three-drug Classes Recruiting ESP 0
NCT06297226 Phase II BMS-986393 Study of BMS-986393 a GPRC5D-directed CAR T Cell Therapy in Adult Participants With Relapsed or Refractory Multiple Myeloma (QUINTESSENTIAL) Recruiting USA | CAN 1
NCT06304636 Phase I Descartes-15 Descartes-15 for Patients With Relapsed/Refractory Multiple Myeloma (DC15-MM-01) Recruiting USA 0
NCT06348108 Phase I Dexamethasone + Iberdomide + Talquetamab-tgvs Talquetamab in Combination With Iberdomide and Dexamethasone for Relapsed or Refractory Multiple Myeloma Not yet recruiting USA 0
NCT06348147 Phase II Bortezomib + Daratumumab + Dexamethasone + Lenalidomide Dara-RVd Induction for Newly Diagnosed Multiple Myeloma With Autologous Stem Cell Transplantation Not yet recruiting USA 0
NCT06351644 Phase Ib/II Dexamethasone + Narazaciclib ON 123300 (Narazaciclib) and Dexamethasone in Patients With Relapsed and/or Refractory Multiple Myeloma Recruiting USA 0
NCT06353022 Phase II Talquetamab-tgvs + Teclistamab Bortezomib + Daratumumab + Dexamethasone + Lenalidomide Lenalidomide + Teclistamab Minimal Residual Disease-based Strategy With T-Cell Redirector After Treatment With Daratumumab, Bortezomib, Lenalidomide, and Dexamethasone (D-VRd) in Newly Diagnosed Multiple Myeloma (IFm2022-01) Not yet recruiting FRA 0
NCT06376526 Phase II Linvoseltamab IMMUNOPLANT for Newly Diagnosed Multiple Myeloma (IMMUNOPLANT) Recruiting USA 0
NCT06381141 Phase I CLN-619 A Study of CLN-619 (Anti-MICA/MICB Antibody) in Patients With Relapsed and Refractory Multiple Myeloma Recruiting USA 0
NCT06411301 Phase I RYZ101 A Phase I Study to Assess the Tolerability of 225Ac-DOTATATE in Patients With Refractory and Relapsing Multiple Myeloma Expressing Somatostatin Receptors (AcTRESS) Not yet recruiting BEL 0
NCT06413498 Phase III Cyclophosphamide + Fludarabine Carfilzomib + Daratumumab + Dexamethasone Daratumumab + Dexamethasone + Pomalidomide Bortezomib + Dexamethasone + Pomalidomide CART-ddBCMA Carfilzomib + Dexamethasone A Study Comparing Anitocabtagene Autoleucel to Standard of Care Therapy in Participants With Relapsed/ Refractory Multiple Myeloma (iMMagine-3) Recruiting USA 0
NCT06421675 Phase II Elranatamab-bcmm Outpatient and Intermittent Dosing of Elranatamab in Relapsed/Refractory Multiple Myeloma (EMBRACE) Not yet recruiting CAN 0
NCT06425991 Phase I Teclistamab A Study Comparing Pre- and Post-Change Teclistamab in Participants With Relapsed or Refractory Multiple Myeloma (MajesTEC-10) Recruiting USA | POL | ITA | GBR | FRA | ESP | DEU | CAN | AUS 1
NCT06433947 Phase I OPN-6602 Dexamethasone + OPN-6602 Study to Assess Safety and Tolerability of OPN-6602 in Subjects With Relapsed and/or Refractory Multiple Myeloma Recruiting USA 0
NCT06461988 Phase II Lenalidomide + Talquetamab-tgvs Talquetamab-tgvs Talquetamab & Lenalidomide as Post Stem Cell Transplant Maintenance in Multiple Myeloma Not yet recruiting USA 0
NCT06465316 Phase I Iberdomide + Teclistamab Testing Teclistamab (TECVAYLI) in Combination With Iberdomide for Relapsed or Refractory Multiple Myeloma Recruiting USA 0
NCT06505369 Phase II Talquetamab-tgvs Teclistamab Bortezomib + Daratumumab + Dexamethasone + Lenalidomide Bispecific T-cell Redirectors as Part of First Line Treatment in Transplant Eligible Multiple Myeloma Patients (TALTEC) Recruiting NOR | EST | DNK 0
NCT06517017 Phase II Dexamethasone + Isatuximab + Lenalidomide Use of Isatuximab, Dexamethasone and Lenalidomide in a Go-Slow Fashion for Ultra-Frail Patients With Multiple Myeloma (UltraFrailMM) Not yet recruiting USA 0
NCT06518551 Phase Ib/II Dexamethasone + Elotuzumab + Iberdomide Elotuzumab + Iberdomide + Dexamethasone Post Ide-Cel in RRMM Not yet recruiting USA 0
NCT06523621 Phase II Nivolumab Nivolumab in Multiple Myeloma Patients After Idecabtagene Vicleucel Not yet recruiting USA 0
NCT06536413 Phase Ib/II Carfilzomib + Dexamethasone + Tretinoin ATRA and Carfilzomib in Plasma Cell Myeloma Patients (ATRA) Recruiting USA 0
NCT06550895 Phase II Daratumumab + Dexamethasone + Lenalidomide Ciltacabtagene autoleucel + Talquetamab-tgvs A Study of Ciltacabtagene Autoleucel and Talquetamab for the Treatment of Participants With High-Risk Multiple Myeloma (MonumenTAL-8) Recruiting USA | AUS 0
NCT06572605 Phase Ib/II Talquetamab-tgvs External Beam Radiation Therapy in Combination With Talquetamab for the Treatment of Multiple Myeloma Patients With Extramedullary Disease Not yet recruiting USA 0
NCT06577025 Phase II Ciltacabtagene autoleucel Cyclophosphamide + Fludarabine Bortezomib + Daratumumab + Dexamethasone + Lenalidomide Daratumumab + Talquetamab-tgvs Daratumumab + Teclistamab A Study of Different Sequences of Cilta-cel, Talquetamab in Combination With Daratumumab and Teclistamab in Combination With Daratumumab Following Induction With Daratumumab, Bortezomib, Lenalidomide and Dexamethasone in Participants With Standard-risk Newly Diagnosed Multiple Myeloma (aMMbition) Recruiting USA | BRA | AUS 0
NCT06582017 Phase I QXL138AM Safety, PK and Efficacy of QXL138AM in Patients With Solid Tumors and Multiple Myeloma Recruiting USA 0
NCT06588660 Phase I ST-067 + Teclistamab ST-067 and Teclistamab for the Treatment of Relapsed or Refractory Multiple Myeloma Not yet recruiting USA 0
NCT06615479 Phase III Carfilzomib + Daratumumab + Dexamethasone + Lenalidomide BMS-986393 + Carfilzomib + Daratumumab + Dexamethasone + Pomalidomide Cyclophosphamide + Fludarabine A Study to Compare the Efficacy and Safety of BMS-986393 Versus Standard Regimens in Adult Participants With Relapsed or Refractory and Lenalidomide-refractory Multiple Myeloma (QUINTESSENTIAL-2) Not yet recruiting USA | TUR | SWE | ROU | POL | NOR | NLD | ITA | ISR | HUN | GRC | GBR | FRA | FIN | ESP | DNK | DEU | CZE | CHE | CAN | BRA | BEL | AUT | AUS | ARG 6
NCT06623630 Phase I Ciltacabtagene autoleucel + Cyclophosphamide Lymphodepleting Total Body Irradiation (TBI) Plus Cyclophosphamide Prior to Ciltacabtagene Autoleucel (Carvykti; Cilta-cel) for Multiple Myeloma (MM) Patients With Impaired Renal Function Not yet recruiting USA 0
NCT06630806 Phase Ib/II SAR446523 A Study to Investigate the Safety and Efficacy of SAR446523 Injected Subcutaneously in Adult Participants With Relapsed/Refractory Myeloma Recruiting AUS 0
NCT06679829 Phase II Melphalan Melphalan + Siltuximab A Study of Melphalan With or Without Siltuximab in People With Multiple Myeloma Having an Autologous Stem Cell Transplant Recruiting USA 0