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| Molecular Profile | CD274 positive |
| Therapy | Carboplatin + Paclitaxel + Pembrolizumab |
| Indication/Tumor Type | cervical cancer |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| CD274 positive | cervical cancer | sensitive | Carboplatin + Paclitaxel + Pembrolizumab | Guideline | Actionable | Keytruda (pembrolizumab) combined with Taxol (paclitaxel) and Paraplatin (carboplatin) is included in guidelines as first-line therapy for patients with CD274 (PD-L1)-positive cervical cancer (NCCN.org). | detail... |
| CD274 positive | cervical cancer | sensitive | Carboplatin + Paclitaxel + Pembrolizumab | FDA approved - On Companion Diagnostic | Actionable | In a Phase III trial (KEYNOTE-826) that supported FDA approval, first-line Keytruda (pembrolizumab) in combination with platinum-based chemotherapy (Platinol (cisplatin) or Paraplatin (carboplatin) plus Taxol (paclitaxel)), with or without Avastin (bevacizumab), improved progression-free survival (10.4 vs 8.1 mo, HR 0.62, p<0.001) compared to placebo in patients with CD274 (PD-L1)-positive (CPS>=1), persistent, recurrent or metastatic cervical cancer (PMID: 34534429; NCT03635567). | detail... 34534429 detail... |
| PubMed Id | Reference Title | Details |
|---|---|---|
| NCCN.org | Full reference... | |
| Full reference... | ||
| Keytruda (pembrolizumab) FDA Drug Label | Full reference... | |
| (34534429) | Pembrolizumab for Persistent, Recurrent, or Metastatic Cervical Cancer. | Full reference... |