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| Molecular Profile | EML4 - ALK |
| Therapy | Ensartinib + Sirolimus |
| Indication/Tumor Type | lung non-small cell carcinoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| EML4 - ALK | lung non-small cell carcinoma | sensitive | Ensartinib + Sirolimus | Preclinical | Actionable | In a preclinical study, transformed non-small cell lung cancer cells harboring EML4-ALK demonstrated enhanced growth inhibition to a combination treatment with Afinitor (sirolimus) and Ensacove (ensartinib) (PMID: 21613408). | 21613408 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (21613408) | Insights into ALK-driven cancers revealed through development of novel ALK tyrosine kinase inhibitors. | Full reference... |