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Molecular Profile EML4 - ALK
Therapy Ensartinib + Sirolimus
Indication/Tumor Type lung non-small cell carcinoma
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
EML4 - ALK lung non-small cell carcinoma sensitive Ensartinib + Sirolimus Preclinical Actionable In a preclinical study, transformed non-small cell lung cancer cells harboring EML4-ALK demonstrated enhanced growth inhibition to a combination treatment with Afinitor (sirolimus) and Ensartinib (X-396) (PMID: 21613408). 21613408
PubMed Id Reference Title Details
(21613408) Insights into ALK-driven cancers revealed through development of novel ALK tyrosine kinase inhibitors. Full reference...