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| Molecular Profile | NRAS Q61K |
| Therapy | Abemaciclib + LY3214996 |
| Indication/Tumor Type | lung carcinoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| NRAS Q61K | lung carcinoma | sensitive | Abemaciclib + LY3214996 | Preclinical - Pdx | Actionable | In a preclinical study, combination treatment with LY3214996 and Verzenio (abemaciclib) led to additive effects on tumor growth inhibition in a patient-derived xenograft (PDX) model of lung carcinoma harboring NRAS Q61K (PMID: 33536188). | 33536188 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (33536188) | ERK Inhibitor LY3214996-Based Treatment Strategies for RAS-Driven Lung Cancer. | Full reference... |