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Molecular Profile | PIK3CA P449T |
Therapy | GSK690693 |
Indication/Tumor Type | colorectal cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
PIK3CA P449T | colorectal cancer | sensitive | GSK690693 | Preclinical - Cell culture | Actionable | In a preclinical study, GSK690693 treatment induced cell death and inhibited proliferation of a colorectal cancer cell line harboring PIK3CA P449T in culture (PMID: 32439931). | 32439931 |
PubMed Id | Reference Title | Details |
---|---|---|
(32439931) | A systematic molecular and pharmacologic evaluation of AKT inhibitors reveals new insight into their biological activity. | Full reference... |