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| Molecular Profile | RB1 inact mut |
| Therapy | BAY 61-3606 |
| Indication/Tumor Type | retinoblastoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| RB1 inact mut | retinoblastoma | sensitive | BAY 61-3606 | Preclinical | Actionable | In a preclinical study, a retinoblastoma cell line was sensitive to BAY 61-3606 in cell culture and in xenograft models, demonstrating increased apoptosis (PMID: 22237022). | 22237022 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (22237022) | A novel retinoblastoma therapy from genomic and epigenetic analyses. | Full reference... |