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Molecular Profile | ALK R1192P |
Therapy | Alectinib + Octreotide |
Indication/Tumor Type | malignant pheochromocytoma |
Response Type | no benefit |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
ALK R1192P | malignant pheochromocytoma | no benefit | Alectinib + Octreotide | Case Reports/Case Series | Actionable | In a clinical case study, addition of Alecensa (alectinib) to Octreotide treatment did not lead to a response in a patient with malignant pheochromocytoma harboring ALK R1192P, with a radiological stable disease after 1 month of treatment and disease progression after 5 months of treatment (PMID: 34371380). | 34371380 |
PubMed Id | Reference Title | Details |
---|---|---|
(34371380) | Sustained response to brigatinib in a patient with refractory metastatic pheochromocytoma harboring R1192P anaplastic lymphoma kinase mutation: a case report from the Austrian Group Medical Tumor Therapy next-generation sequencing registry and discussion of the literature. | Full reference... |