malignant pheochromocytoma
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ID DOID:0080347
Name malignant pheochromocytoma
Definition An adrenal medulla cancer that arises within the adrenal medulla, releasing epinephrines and norepinephrines hormones.
Source DiseaseOntology.org
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ICDO:8700/3
Path disease disease of cellular proliferation cancer organ system cancer endocrine gland cancer adrenal gland cancer adrenal medulla cancer malignant pheochromocytoma

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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
ALK R1192P Alectinib + Octreotide malignant pheochromocytoma no benefit detail...
ALK R1192P Brigatinib malignant pheochromocytoma predicted - sensitive detail...
RET C634F Selpercatinib malignant pheochromocytoma predicted - sensitive detail...
RET C618S Selpercatinib malignant pheochromocytoma predicted - sensitive detail...
RET M918T Selpercatinib malignant pheochromocytoma predicted - sensitive detail...
RET C634R Selpercatinib malignant pheochromocytoma predicted - sensitive detail...
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT01371201 Phase II Sunitinib First International Randomized Study in Malignant Progressive Pheochromocytoma and Paraganglioma (FIRSTMAPPP) Completed NLD | ITA | FRA | DEU 0
NCT04187404 Phase Ib/II EO2401 + Nivolumab A Novel Therapeutic Vaccine (EO2401) in Metastatic Adrenocortical Carcinoma, or Malignant Pheochromocytoma/Paraganglioma (Spencer) Terminated USA | SWE | NLD | ITA | FRA | ESP | DNK | DEU 0
NCT04394858 Phase II Olaparib + Temozolomide Temozolomide Testing the Addition of an Anticancer Drug, Olaparib, to the Usual Chemotherapy (Temozolomide) for Advanced Neuroendocrine Cancer Active, not recruiting USA 0
NCT05944237 Phase Ib/II Atezolizumab + HTL0039732 HTL0039732 HTL0039732 in Participants With Advanced Solid Tumours Recruiting GBR 0