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ID | DOID:80347 |
Name | malignant pheochromocytoma |
Definition | An adrenal medulla cancer that arises within the adrenal medulla, releasing epinephrines and norepinephrines hormones. |
Source | DiseaseOntology.org |
Alt Ids | |
Path | disease disease of cellular proliferation cancer organ system cancer endocrine gland cancer adrenal gland cancer adrenal medulla cancer malignant pheochromocytoma |
Molecular Profile | Therapy | Indication/Tumor Type | Response Type | Profile Response Detail |
---|---|---|---|---|
ALK R1192P | Alectinib + Octreotide | malignant pheochromocytoma | no benefit | detail... |
ALK R1192P | Brigatinib | malignant pheochromocytoma | predicted - sensitive | detail... |
RET C634F | Selpercatinib | malignant pheochromocytoma | predicted - sensitive | detail... |
RET C618S | Selpercatinib | malignant pheochromocytoma | predicted - sensitive | detail... |
RET M918T | Selpercatinib | malignant pheochromocytoma | predicted - sensitive | detail... |
RET C634R | Selpercatinib | malignant pheochromocytoma | predicted - sensitive | detail... |
Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
---|---|---|---|---|---|---|
NCT01371201 | Phase II | Sunitinib | First International Randomized Study in Malignant Progressive Pheochromocytoma and Paraganglioma (FIRSTMAPPP) | Completed | NLD | ITA | FRA | DEU | 0 |
NCT04187404 | Phase Ib/II | EO2401 + Nivolumab | A Novel Therapeutic Vaccine (EO2401) in Metastatic Adrenocortical Carcinoma, or Malignant Pheochromocytoma/Paraganglioma (Spencer) | Terminated | USA | SWE | NLD | ITA | FRA | ESP | DNK | DEU | 0 |
NCT04394858 | Phase II | Olaparib + Temozolomide Temozolomide | Testing the Addition of an Anticancer Drug, Olaparib, to the Usual Chemotherapy (Temozolomide) for Advanced Neuroendocrine Cancer | Recruiting | USA | 0 |