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ID DOID:80347
Name malignant pheochromocytoma
Definition An adrenal medulla cancer that arises within the adrenal medulla, releasing epinephrines and norepinephrines hormones.
Source DiseaseOntology.org
Alt Ids
Path disease disease of cellular proliferation cancer organ system cancer endocrine gland cancer adrenal gland cancer adrenal medulla cancer malignant pheochromocytoma

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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
ALK R1192P Alectinib + Octreotide malignant pheochromocytoma no benefit detail...
ALK R1192P Brigatinib malignant pheochromocytoma predicted - sensitive detail...
RET C634F Selpercatinib malignant pheochromocytoma predicted - sensitive detail...
RET C618S Selpercatinib malignant pheochromocytoma predicted - sensitive detail...
RET M918T Selpercatinib malignant pheochromocytoma predicted - sensitive detail...
RET C634R Selpercatinib malignant pheochromocytoma predicted - sensitive detail...
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT01371201 Phase II Sunitinib First International Randomized Study in Malignant Progressive Pheochromocytoma and Paraganglioma (FIRSTMAPPP) Completed NLD | ITA | FRA | DEU 0
NCT04187404 Phase Ib/II EO2401 + Nivolumab A Novel Therapeutic Vaccine (EO2401) in Metastatic Adrenocortical Carcinoma, or Malignant Pheochromocytoma/Paraganglioma (Spencer) Terminated USA | SWE | NLD | ITA | FRA | ESP | DNK | DEU 0
NCT04394858 Phase II Olaparib + Temozolomide Temozolomide Testing the Addition of an Anticancer Drug, Olaparib, to the Usual Chemotherapy (Temozolomide) for Advanced Neuroendocrine Cancer Recruiting USA 0