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| Molecular Profile | BRAF N486_P490del |
| Therapy | Cobimetinib |
| Indication/Tumor Type | melanoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| BRAF N486_P490del | melanoma | sensitive | Cobimetinib | Preclinical - Cell culture | Actionable | In a preclinical study, a melanoma cell line harboring BRAF N486_P490del demonstrated sensitivity to Cotellic (cobimetinib), resulting in decreased cell viability in culture (PMID: 26996308). | 26996308 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (26996308) | Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2. | Full reference... |