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Molecular Profile BRAF V600E
Therapy Nab-paclitaxel + Vemurafenib
Indication/Tumor Type triple-receptor negative breast cancer
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF V600E triple-receptor negative breast cancer predicted - sensitive Nab-paclitaxel + Vemurafenib Case Reports/Case Series Actionable In a clinical case study, Zelboraf (vemurafenib) and Abraxane (nab-paclitaxel) combination treatment resulted in regression of some metastatic pulmonary lesions and a progression-free survival of 4.4 months in a patient with triple-negative breast cancer harboring BRAF V600E, but a biopsy in lesions that progressed showed acquisition of additional mutations in PDGFRB, NF2, GRM3, MLH1, FOXA1, LRP1B, and AR amplification (PMID: 34818649). 34818649
PubMed Id Reference Title Details
(34818649) BRAF V600E Mutation in Triple-Negative Breast Cancer: A Case Report and Literature Review. Full reference...