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| Molecular Profile | IDH2 V305M |
| Therapy | Olaparib |
| Indication/Tumor Type | malignant epithelioid hemangioendothelioma |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| IDH2 V305M | malignant epithelioid hemangioendothelioma | predicted - sensitive | Olaparib | Case Reports/Case Series | Actionable | In a Phase II trial (OLAPCO), Lynparza (olaparib) treatment resulted in stable disease lasting 11 months in a patient with pulmonary epithelioid hemangioendothelioma harboring IDH2 V305M (PMID: 34994649, NCT02576444). | 34994649 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (34994649) | Clinical Efficacy of Olaparib in IDH1/IDH2-Mutant Mesenchymal Sarcomas. | Full reference... |