Profile Response Detail

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Molecular Profile FGFR1 N546K
Therapy Pemigatinib
Indication/Tumor Type pilocytic astrocytoma
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR1 N546K pilocytic astrocytoma predicted - sensitive Pemigatinib Case Reports/Case Series Actionable In a Phase I trial (FIGHT-101), Pemazyre (pemigatinib) treatment resulted in a partial response with a 52% decrease in tumor size at first restaging and a 91% tumor reduction after 13 cycles in a patient with pilocytic astrocytoma harboring FGFR1 N546K, with the response lasting 18 months (PMID: 35507888; NCT02393248). 35507888
PubMed Id Reference Title Details
(35507888) Activity of Pemigatinib in Pilocytic Astrocytoma and FGFR1N546K Mutation. Full reference...