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| ID | DOID:4851 |
| Name | pilocytic astrocytoma |
| Definition | A childhood low-grade glioma that is characterized by cells that look like fibers when viewed under a microscope and is located_in the brain. |
| Source | DiseaseOntology.org |
| Alt Ids | |
| Path | disease disease of cellular proliferation benign neoplasm cell type benign neoplasm low grade glioma childhood low-grade glioma pilocytic astrocytoma |
| Molecular Profile | Therapy | Indication/Tumor Type | Response Type | Profile Response Detail |
|---|---|---|---|---|
| BRAF V600E | Dabrafenib | pilocytic astrocytoma | predicted - sensitive | detail... |
| BRAF V600D | Dabrafenib + Trametinib | pilocytic astrocytoma | predicted - sensitive | detail... |
| BRAF fusion | N/A | pilocytic astrocytoma | not applicable | detail... |
| BRAF V600E | Dabrafenib + Trametinib | pilocytic astrocytoma | sensitive | detail... |
| BRAF V600E | Cobimetinib + Vemurafenib | pilocytic astrocytoma | sensitive | detail... |
| BRAF V600E | Selumetinib | pilocytic astrocytoma | sensitive | detail... |
| BRAF fusion | Selumetinib | pilocytic astrocytoma | sensitive | detail... |
| BRAF V600E | Vemurafenib | pilocytic astrocytoma | predicted - sensitive | detail... |
| FGFR1 N546K | Pemigatinib | pilocytic astrocytoma | predicted - sensitive | detail... |
| BRAF A598_T599insV | Dabrafenib | pilocytic astrocytoma | predicted - sensitive | detail... |
| BRAF V600X | Tovorafenib | pilocytic astrocytoma | sensitive | detail... |
| BRAF rearrange | Tovorafenib | pilocytic astrocytoma | sensitive | detail... |
| BRAF fusion | Tovorafenib | pilocytic astrocytoma | sensitive | detail... |
| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT01089101 | Phase Ib/II | Selumetinib | Selumetinib in Treating Young Patients With Recurrent or Refractory Low Grade Glioma | Active, not recruiting | USA | 0 |
| NCT01734512 | Phase II | Everolimus | PNOC 001: Phase II Study of Everolimus for Recurrent or Progressive Low-grade Gliomas in Children | Completed | USA | 0 |
| NCT01837862 | Phase Ib/II | Carboplatin + Mebendazole + Temozolomide + Vincristine Sulfate Bevacizumab + Irinotecan + Mebendazole | A Phase I/II Study of Mebendazole for the Treatment of Pediatric Gliomas | Completed | USA | 0 |
| NCT01999270 | Phase I | Bevacizumab + Irinotecan | Evaluation of FDOPA-PET/MRI in Pediatric Patients With CNS Tumors | Completed | USA | 0 |
| NCT03975829 | FDA approved | Dabrafenib + Trametinib | Pediatric Long-Term Follow-up and Rollover Study | Active, not recruiting | USA | SWE | NLD | ITA | ISR | GBR | FRA | FIN | ESP | DNK | DEU | CZE | CAN | BRA | BEL | AUS | ARG | 2 |
| NCT04541082 | Phase I | ONC206 | Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms | Recruiting | USA | 0 |
| NCT04923126 | Phase Ib/II | Mirdametinib | SJ901: Evaluation of Mirdametinib in Children, Adolescents, and Young Adults With Low-Grade Glioma | Recruiting | USA | 0 |
| NCT05267106 | Phase II | Pemigatinib | Study to Evaluate the Efficacy and Safety of Pemigatinib in Participants With Previously Treated Glioblastoma or Other Primary Central Nervous System Tumors Harboring Activating FGFR1-3 Alterations (FIGHT-209) | Terminated | USA | NLD | ITA | GBR | FRA | ESP | DNK | DEU | 1 |
| NCT05503797 | Phase II | PLX8394 | A Study to Assess the Efficacy and Safety of FORE8394 in Participants With Cancer Harboring BRAF Alterations | Recruiting | USA | SWE | NOR | ITA | GBR | FRA | ESP | DEU | CAN | AUS | 1 |