pilocytic astrocytoma
Disease Detail

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ID DOID:4851
Name pilocytic astrocytoma
Definition A childhood low-grade glioma that is characterized by cells that look like fibers when viewed under a microscope and is located_in the brain.
Source DiseaseOntology.org
Alt Ids
Path disease disease of cellular proliferation benign neoplasm cell type benign neoplasm low grade glioma childhood low-grade glioma pilocytic astrocytoma

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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
BRAF V600E Dabrafenib pilocytic astrocytoma predicted - sensitive detail...
BRAF V600D Dabrafenib + Trametinib pilocytic astrocytoma predicted - sensitive detail...
BRAF fusion N/A pilocytic astrocytoma not applicable detail...
BRAF V600E Dabrafenib + Trametinib pilocytic astrocytoma sensitive detail...
BRAF V600E Cobimetinib + Vemurafenib pilocytic astrocytoma sensitive detail...
BRAF V600E Selumetinib pilocytic astrocytoma sensitive detail...
BRAF fusion Selumetinib pilocytic astrocytoma sensitive detail...
BRAF V600E Vemurafenib pilocytic astrocytoma predicted - sensitive detail...
FGFR1 N546K Pemigatinib pilocytic astrocytoma predicted - sensitive detail...
BRAF A598_T599insV Dabrafenib pilocytic astrocytoma predicted - sensitive detail...
NTRK1 fusion Repotrectinib pilocytic astrocytoma sensitive detail...
NTRK2 fusion Repotrectinib pilocytic astrocytoma sensitive detail...
BRAF V600X Tovorafenib pilocytic astrocytoma sensitive detail...
BRAF rearrange Tovorafenib pilocytic astrocytoma sensitive detail...
BRAF fusion Tovorafenib pilocytic astrocytoma sensitive detail...
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT01089101 Phase Ib/II Selumetinib Selumetinib in Treating Young Patients With Recurrent or Refractory Low Grade Glioma Active, not recruiting USA 0
NCT01734512 Phase II Everolimus PNOC 001: Phase II Study of Everolimus for Recurrent or Progressive Low-grade Gliomas in Children Completed USA 0
NCT01837862 Phase Ib/II Carboplatin + Mebendazole + Temozolomide + Vincristine Sulfate Bevacizumab + Irinotecan + Mebendazole A Phase I/II Study of Mebendazole for the Treatment of Pediatric Gliomas Completed USA 0
NCT01999270 Phase I Bevacizumab + Irinotecan Evaluation of FDOPA-PET/MRI in Pediatric Patients With CNS Tumors Completed USA 0
NCT03975829 FDA approved Dabrafenib + Trametinib Pediatric Long-Term Follow-up and Rollover Study Recruiting USA | SWE | NLD | ITA | ISR | GBR | FRA | FIN | ESP | DNK | DEU | CZE | CAN | BRA | BEL | AUS | ARG 2
NCT04541082 Phase I ONC206 Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms Recruiting USA 0
NCT04923126 Phase Ib/II Mirdametinib SJ901: Evaluation of Mirdametinib in Children, Adolescents, and Young Adults With Low-Grade Glioma Recruiting USA 0
NCT05267106 Phase II Pemigatinib Study to Evaluate the Efficacy and Safety of Pemigatinib in Participants With Previously Treated Glioblastoma or Other Primary Central Nervous System Tumors Harboring Activating FGFR1-3 Alterations (FIGHT-209) Completed USA | NLD | ITA | GBR | FRA | ESP | DNK | DEU 1
NCT05503797 Phase II Cobicistat + PLX8394 PLX8394 A Study to Assess the Efficacy and Safety of FORE8394 in Participants With Cancer Harboring BRAF Alterations Recruiting USA | SWE | ITA | GBR | FRA | ESP | DEU | CAN | AUS 1