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Molecular Profile | TSC1 loss |
Therapy | Luminespib + Torin 1 |
Indication/Tumor Type | urinary bladder cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
TSC1 loss | urinary bladder cancer | sensitive | Luminespib + Torin 1 | Preclinical | Actionable | In a preclinical study, Luminespib (AUY922), in combination with Torin 1 inhibited growth of bladder cancer cells lacking TSC1 to a greater extent than either therapy alone (PMID: 23401075). | 23401075 |
PubMed Id | Reference Title | Details |
---|---|---|
(23401075) | TSC1 involvement in bladder cancer: diverse effects and therapeutic implications. | Full reference... |