Therapy Detail
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| Therapy Name | Luminespib + Torin 1 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Luminespib | AUY922|NVP-AUY922 | HSP90 Inhibitor 35 | Luminespib (AUY922) inhibits HSP90, resulting in increased tumor cell apoptosis and decreased tumor cell angiogenesis and proliferation (PMID: 25955495, PMID: 18413753, PMID: 32592377). | |
| Torin 1 | Torin1 | mTOR Inhibitor 51 | Torin 1 inhibits mTOR signaling through mTORC1 and mTORC2, thereby preventing cell proliferation (PMID: 19209957, PMID: 29063293). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| TSC1 loss | urinary bladder cancer | sensitive | Luminespib + Torin 1 | Preclinical | Actionable | In a preclinical study, Luminespib (AUY922), in combination with Torin 1 inhibited growth of bladder cancer cells lacking TSC1 to a greater extent than either therapy alone (PMID: 23401075). | 23401075 |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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