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Molecular Profile | JAK2 R683G JAK2 E864K |
Therapy | NVP-BVB808 |
Indication/Tumor Type | cancer |
Response Type | resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
JAK2 R683G JAK2 E864K | cancer | resistant | NVP-BVB808 | Preclinical | Actionable | In a preclinical study, cells expressing the JAK2 R683G/E864K double mutation demonstrated resistance to NVP-BVB808 in culture (PMID: 22271575). | 22271575 |
PubMed Id | Reference Title | Details |
---|---|---|
(22271575) | Genetic resistance to JAK2 enzymatic inhibitors is overcome by HSP90 inhibition. | Full reference... |