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Molecular Profile | FGFR2 amp |
Therapy | CPL304110 |
Indication/Tumor Type | stomach carcinoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FGFR2 amp | stomach carcinoma | sensitive | CPL304110 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, CPL304110 treatment inhibited downstream signaling and proliferation of a gastric carcinoma cell line harboring FGFR2 amplification in culture and inhibited tumor growth in cell line xenograft models (PMID: 33199155). | 33199155 |
PubMed Id | Reference Title | Details |
---|---|---|
(33199155) | Discovery and optimization of novel pyrazole-benzimidazole CPL304110, as a potent and selective inhibitor of fibroblast growth factor receptors FGFR (1-3). | Full reference... |