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Therapy Name	CPL304110
Synonyms
Therapy Description	CPL304110 inhibits FGFR1, 2, and 3, which may inhibit FGFR signaling pathways, proliferation, and tumor growth (PMID: 33199155).

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
CPL304110		CPL-304110	FGFR1 Inhibitor 28 FGFR2 Inhibitor 24 FGFR3 Inhibitor 21	CPL304110 inhibits FGFR1, 2, and 3, which may inhibit FGFR signaling pathways, proliferation, and tumor growth (PMID: 33199155).

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
FGFR2 amp	lung non-small cell carcinoma	sensitive	CPL304110	Preclinical - Pdx	Actionable	In a preclinical study, CPL304110 inhibited tumor growth in a patient-derived xenograft (PDX) model of FGFR2-amplified non-small cell lung cancer, however, regrowth was observed after treatment was stopped (PMID: 38282676).	38282676
FGFR2 amp	stomach cancer	sensitive	CPL304110	Preclinical - Pdx & cell culture	Actionable	In a preclinical study, CPL304110 inhibited Erk phosphorylation and viability in an FGFR2-amplified gastric cancer cell line in culture, inhibited growth in a cell line xenograft model, and induced tumor regression in a patient-derived xenograft (PDX) model (PMID: 38282676).	38282676
FGFR2 amp	stomach carcinoma	sensitive	CPL304110	Preclinical - Cell line xenograft	Actionable	In a preclinical study, CPL304110 treatment inhibited downstream signaling and proliferation of a gastric carcinoma cell line harboring FGFR2 amplification in culture and inhibited tumor growth in cell line xenograft models (PMID: 33199155).	33199155
FGFR3 S249C	urinary bladder cancer	sensitive	CPL304110	Preclinical - Cell line xenograft	Actionable	In a preclinical study, CPL304110 inhibited Erk phosphorylation in a bladder cancer cell line harboring FGFR3 S249C in culture and inhibited tumor growth in a cell line xenograft model (PMID: 38282676).	38282676
FGFR1 amp	lung non-small cell carcinoma	sensitive	CPL304110	Preclinical - Cell culture	Actionable	In a preclinical study, CPL304110 treatment inhibited proliferation of a non-small cell lung cancer cell line harboring FGFR1 amplification in culture (PMID: 33199155).	33199155
FGFR2 amp	endometrial cancer	sensitive	CPL304110	Preclinical - Cell culture	Actionable	In a preclinical study, CPL304110 inhibited viability of an FGFR2-amplified endometrial cancer cell line in culture (PMID: 38282676).	38282676
FGFR3 fusion FGFR3 amp	bladder carcinoma	sensitive	CPL304110	Preclinical - Cell culture	Actionable	In a preclinical study, CPL304110 treatment inhibited proliferation of a bladder carcinoma cell line harboring FGFR3 amplification and an FGFR3 fusion in culture (PMID: 33199155).	33199155
FGFR3 S249C	bladder carcinoma	sensitive	CPL304110	Preclinical - Cell culture	Actionable	In a preclinical study, CPL304110 treatment inhibited proliferation of a bladder carcinoma cell line harboring FGFR3 S249C in culture (PMID: 33199155).	33199155

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Clinical Trial	Phase	Therapies	Title	Recruitment Status	Covered Countries	Other Countries
NCT04149691	Phase I	CPL304110	Safety, Tolerability and Pharmacokinetics of Oral CPL304110, in Adult Subjects With Advanced Solid Malignancies	Recruiting	POL	0

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