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| Molecular Profile | MSH6 loss |
| Therapy | N/A |
| Indication/Tumor Type | colon carcinoma |
| Response Type | not applicable |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| MSH6 loss | colon carcinoma | not applicable | N/A | Preclinical | Emerging | Preclinical shRNA mediated-inhibition of PTEN-induced putative kinase 1 (PINK1) in colon carcinoma cells with MSH6 loss resulted in synthetic lethality, suggesting PINK1 may be a promising therapeutic target for MSH6 deficient cancer cells (PMID: 21242281). | 21242281 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (21242281) | Parallel high-throughput RNA interference screens identify PINK1 as a potential therapeutic target for the treatment of DNA mismatch repair-deficient cancers. | Full reference... |