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ID | DOID:1520 |
Name | colon carcinoma |
Definition | A colon cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells. |
Source | DiseaseOntology.org |
Alt Ids | |
Path | disease disease of cellular proliferation cancer organ system cancer gastrointestinal system cancer intestinal cancer large intestine cancer colorectal cancer colon cancer colon carcinoma |
Molecular Profile | Therapy | Indication/Tumor Type | Response Type | Profile Response Detail |
---|---|---|---|---|
BRAF V600E | RXDX-105 | colon carcinoma | sensitive | detail... |
MSH6 loss | N/A | colon carcinoma | not applicable | detail... |
APC inact mut | FH535 | colon carcinoma | sensitive | detail... |
TP53 loss | SP600125 | colon carcinoma | sensitive | detail... |
TP53 loss | MPI-0479605 | colon carcinoma | sensitive | detail... |
TP53 wild-type | MPI-0479605 | colon carcinoma | sensitive | detail... |
RB1 wild-type TP53 wild-type | R547 | colon carcinoma | sensitive | detail... |
RB1 wild-type TP53 mut | R547 | colon carcinoma | sensitive | detail... |
IDH1 R132H | Talazoparib | colon carcinoma | sensitive | detail... |
IDH1 R132H | Olaparib | colon carcinoma | sensitive | detail... |
TP53 mutant | Camptothecin + CHIR-124 | colon carcinoma | predicted - sensitive | detail... |
ALK negative | CEP-28122 | colon carcinoma | resistant | detail... |
CTNNB1 S45del | NTRC 0066-0 | colon carcinoma | predicted - sensitive | detail... |
CTNNB1 S45del | Mps-BAY2b | colon carcinoma | predicted - sensitive | detail... |
CTNNB1 S45del | NMS-P715 | colon carcinoma | predicted - sensitive | detail... |
CTNNB1 S45del | BAY1161909 | colon carcinoma | predicted - sensitive | detail... |
CTNNB1 S45del | BAY1217389 | colon carcinoma | predicted - sensitive | detail... |
CTNNB1 S45del | Mps1-IN-1 | colon carcinoma | predicted - sensitive | detail... |
CTNNB1 S45del | MPI-0479605 | colon carcinoma | predicted - sensitive | detail... |
TP53 wild-type | AZ32 + Radiotherapy | colon carcinoma | sensitive | detail... |
TP53 R248W | AZ32 + Radiotherapy | colon carcinoma | predicted - sensitive | detail... |
VHL Y112C | ARV-771 | colon carcinoma | resistant | detail... |
VHL H110L | ARV-771 | colon carcinoma | sensitive | detail... |
BRAF D594G | Cetuximab + Trametinib | colon carcinoma | predicted - sensitive | detail... |
Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
---|---|---|---|---|---|---|
NCT01309126 | Phase III | Cetuximab Cetuximab + PGG beta-glucan | Study of Imprime PGG in Combination With Cetuximab in Subjects With Recurrent or Progressive KRAS Wild Type Colorectal Cancer | Terminated | USA | FRA | DEU | 1 |
NCT01985763 | Phase Ib/II | Genistein Bevacizumab Fluorouracil + Leucovorin + Oxaliplatin + Pembrolizumab | Genistein in Treatment of Metastatic Colorectal Cancer | Completed | USA | 0 |
NCT02723955 | Phase I | GSK3359609 GSK3359609 + Pembrolizumab | Dose Escalation and Expansion Study of GSK3359609 in Subjects With Selected Advanced Solid Tumors (INDUCE-1) | Completed | USA | NLD | ITA | FRA | ESP | CAN | AUS | 2 |
NCT02890758 | Phase I | Nogapendekin alfa inbakicept | Phase I Trial of Universal Donor NK Cell Therapy in Combination With ALT803 | Completed | USA | 0 |
NCT03986606 | Phase I | PSB205 | A Study of PSB205 in Subjects With Advanced Solid Tumors | Unknown status | USA | 0 |