colon carcinoma
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ID DOID:1520
Name colon carcinoma
Definition A colon cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.
Source DiseaseOntology.org
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SNOMEDCT_US_2023_03_01:154454005
Path disease disease of cellular proliferation cancer organ system cancer gastrointestinal system cancer intestinal cancer large intestine cancer colorectal cancer colon cancer colon carcinoma

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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
BRAF V600E RXDX-105 colon carcinoma sensitive detail...
MSH6 loss N/A colon carcinoma not applicable detail...
APC inact mut FH535 colon carcinoma sensitive detail...
TP53 loss SP600125 colon carcinoma sensitive detail...
TP53 loss MPI-0479605 colon carcinoma sensitive detail...
TP53 wild-type MPI-0479605 colon carcinoma sensitive detail...
RB1 wild-type TP53 wild-type R547 colon carcinoma sensitive detail...
RB1 wild-type TP53 mut R547 colon carcinoma sensitive detail...
IDH1 R132H Talazoparib colon carcinoma sensitive detail...
IDH1 R132H Olaparib colon carcinoma sensitive detail...
TP53 mutant Camptothecin + CHIR-124 colon carcinoma predicted - sensitive detail...
ALK negative CEP-28122 colon carcinoma resistant detail...
CTNNB1 S45del NTRC 0066-0 colon carcinoma predicted - sensitive detail...
CTNNB1 S45del Mps-BAY2b colon carcinoma predicted - sensitive detail...
CTNNB1 S45del NMS-P715 colon carcinoma predicted - sensitive detail...
CTNNB1 S45del BAY1161909 colon carcinoma predicted - sensitive detail...
CTNNB1 S45del BAY1217389 colon carcinoma predicted - sensitive detail...
CTNNB1 S45del Mps1-IN-1 colon carcinoma predicted - sensitive detail...
CTNNB1 S45del MPI-0479605 colon carcinoma predicted - sensitive detail...
TP53 wild-type AZ32 + Radiotherapy colon carcinoma sensitive detail...
TP53 R248W AZ32 + Radiotherapy colon carcinoma predicted - sensitive detail...
VHL Y112C ARV-771 colon carcinoma resistant detail...
VHL H110L ARV-771 colon carcinoma sensitive detail...
BRAF D594G Cetuximab + Trametinib colon carcinoma predicted - sensitive detail...
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT01309126 Phase III Cetuximab Cetuximab + PGG beta-glucan Study of Imprime PGG in Combination With Cetuximab in Subjects With Recurrent or Progressive KRAS Wild Type Colorectal Cancer Terminated USA | FRA | DEU 1
NCT01985763 Phase Ib/II Genistein Bevacizumab Fluorouracil + Leucovorin + Oxaliplatin + Pembrolizumab Genistein in Treatment of Metastatic Colorectal Cancer Completed USA 0
NCT02723955 Phase I GSK3359609 GSK3359609 + Pembrolizumab Dose Escalation and Expansion Study of GSK3359609 in Subjects With Selected Advanced Solid Tumors (INDUCE-1) Completed USA | NLD | ITA | FRA | ESP | CAN | AUS 2
NCT02890758 Phase I Nogapendekin alfa inbakicept Phase I Trial of Universal Donor NK Cell Therapy in Combination With ALT803 Completed USA 0
NCT03986606 Phase I PSB205 A Study of PSB205 in Subjects With Advanced Solid Tumors Unknown status USA 0