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| Molecular Profile | PALB2 inact mut |
| Therapy | Olaparib |
| Indication/Tumor Type | Advanced Solid Tumor |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| PALB2 inact mut | Advanced Solid Tumor | sensitive | Olaparib | Preclinical | Actionable | In a preclinical study, Lynparza (olaparib) resulted in decreased cell survival in a PALB2 deficient cell line derived from a Fanconi anemia patient (PMID: 20871615). | 20871615 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (20871615) | Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination. | Full reference... |