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Molecular Profile | KIT K509I |
Therapy | Imatinib |
Indication/Tumor Type | gastrointestinal stromal tumor |
Response Type | no benefit |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
KIT K509I | gastrointestinal stromal tumor | no benefit | Imatinib | Case Reports/Case Series | Actionable | In a clinical case study, Gleevec (imatinib) treatment resulted in stable disease at 9 months in a patient with advanced gastrointestinal stromal tumor harboring a germline KIT K509I mutation, which was later discontinued due to adverse effects and lack of response (PMID: 23610110). | 23610110 |
PubMed Id | Reference Title | Details |
---|---|---|
(23610110) | Rare, germline mutation of KIT with imatinib-resistant multiple GI stromal tumors and mastocytosis. | Full reference... |