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| Molecular Profile | KIT F522C |
| Therapy | Imatinib |
| Indication/Tumor Type | systemic mastocytosis |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| KIT F522C | systemic mastocytosis | sensitive | Imatinib | Case Reports/Case Series | Actionable | In a clinical case study, Gleevec (imatinib) treatment resulted in symptom and pathologic improvements in a patient with systemic mastocytosis harboring germline KIT F522C and inhibited growth of primary bone marrow cells derived from the patient in culture (PMID: 15070706). | 15070706 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (15070706) | A novel form of mastocytosis associated with a transmembrane c-kit mutation and response to imatinib. | Full reference... |