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Molecular Profile | KIT F522C |
Therapy | Imatinib |
Indication/Tumor Type | systemic mastocytosis |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
KIT F522C | systemic mastocytosis | sensitive | Imatinib | Case Reports/Case Series | Actionable | In a clinical case study, Gleevec (imatinib) treatment resulted in symptom and pathologic improvements in a patient with systemic mastocytosis harboring germline KIT F522C and inhibited growth of primary bone marrow cells derived from the patient in culture (PMID: 15070706). | 15070706 |
PubMed Id | Reference Title | Details |
---|---|---|
(15070706) | A novel form of mastocytosis associated with a transmembrane c-kit mutation and response to imatinib. | Full reference... |