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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
KIT D816V Imatinib systemic mastocytosis resistant detail...
KIT D816V Avapritinib systemic mastocytosis sensitive detail...
KIT D816V N/A systemic mastocytosis not applicable detail...
KIT D816X N/A systemic mastocytosis not applicable detail...
CBL mutant N/A systemic mastocytosis not applicable detail...
KIT K509I Imatinib systemic mastocytosis sensitive detail...
KIT K509I Dasatinib systemic mastocytosis sensitive detail...
KIT K509I Midostaurin systemic mastocytosis predicted - sensitive detail...
KIT F522C Imatinib systemic mastocytosis sensitive detail...
KIT D816_N822delinsMIDSI Avapritinib systemic mastocytosis predicted - sensitive detail...
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04681105 Phase I Acetaminophen + Dexamethasone + Diphenhydramine + Flotetuzumab + Ranitidine Dexamethasone + Diphenhydramine + Flotetuzumab + Ibuprofen + Ranitidine Flotetuzumab for the Treatment of Relapsed or Refractory Advanced CD123-Positive Hematological Malignancies Active, not recruiting USA 0
NCT04996875 Phase II PLX9486 (Apex) Bezuclastinib in Patients With Advanced Systemic Mastocytosis Recruiting USA | POL | NOR | NLD | ITA | GBR | FRA | ESP | DEU | CHE | CAN | BEL | AUT | AUS 0
NCT05609942 Phase Ib/II Elenestinib Azacitidine + Elenestinib Study of Elenestinib (BLU-263) in Advanced Systemic Mastocytosis (AdvSM) and and Other KIT Altered Hematologic Malignancies (AZURE) Recruiting USA | NOR | NLD | FRA | ESP | DEU | BEL 0