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ID | DOID:349 |
Name | systemic mastocytosis |
Definition | |
Source | DiseaseOntology.org |
Alt Ids | |
Path | disease disease of anatomical entity hematopoietic system disease leukocyte disease mastocytosis systemic mastocytosis |
Molecular Profile | Therapy | Indication/Tumor Type | Response Type | Profile Response Detail |
---|---|---|---|---|
KIT D816V | Imatinib | systemic mastocytosis | resistant | detail... |
KIT D816V | Avapritinib | systemic mastocytosis | sensitive | detail... |
KIT D816V | N/A | systemic mastocytosis | not applicable | detail... |
KIT D816X | N/A | systemic mastocytosis | not applicable | detail... |
CBL mutant | N/A | systemic mastocytosis | not applicable | detail... |
KIT K509I | Imatinib | systemic mastocytosis | sensitive | detail... |
KIT K509I | Dasatinib | systemic mastocytosis | sensitive | detail... |
KIT K509I | Midostaurin | systemic mastocytosis | predicted - sensitive | detail... |
KIT F522C | Imatinib | systemic mastocytosis | sensitive | detail... |
KIT D816_N822delinsMIDSI | Avapritinib | systemic mastocytosis | predicted - sensitive | detail... |
Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
---|---|---|---|---|---|---|
NCT04681105 | Phase I | Acetaminophen + Dexamethasone + Diphenhydramine + Flotetuzumab + Ranitidine Dexamethasone + Diphenhydramine + Flotetuzumab + Ibuprofen + Ranitidine | Flotetuzumab for the Treatment of Relapsed or Refractory Advanced CD123-Positive Hematological Malignancies | Active, not recruiting | USA | 0 |
NCT04996875 | Phase II | PLX9486 | (Apex) Bezuclastinib in Patients With Advanced Systemic Mastocytosis | Recruiting | USA | POL | NOR | NLD | ITA | GBR | FRA | ESP | DEU | CHE | CAN | BEL | AUT | AUS | 0 |
NCT05609942 | Phase Ib/II | Elenestinib Azacitidine + Elenestinib | Study of Elenestinib (BLU-263) in Advanced Systemic Mastocytosis (AdvSM) and and Other KIT Altered Hematologic Malignancies (AZURE) | Recruiting | USA | NOR | NLD | FRA | ESP | DEU | BEL | 0 |