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Molecular Profile | BRAF G466V |
Therapy | CFT1946 |
Indication/Tumor Type | lung cancer |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BRAF G466V | lung cancer | predicted - sensitive | CFT1946 | Preclinical - Cell culture | Actionable | In a preclinical study, CFT1946 treatment inhibited proliferation of a lung cancer cell line harboring heterozygous BRAF G466V in culture (Cancer Res 2022;82(12_Suppl):Abstract nr 2158). | detail... |
PubMed Id | Reference Title | Details |
---|---|---|
Preclinical evaluation of CFT1946 as a selective degrader of mutant BRAF for the treatment of BRAF driven cancers | Full reference... |