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Molecular Profile | PTEN loss |
Therapy | Everolimus |
Indication/Tumor Type | clear cell renal cell carcinoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
PTEN loss | clear cell renal cell carcinoma | sensitive | Everolimus | Preclinical - Cell culture | Actionable | In a preclinical study, Afinitor (everolimus) inhibited cell proliferation in PTEN-deficient clear cell renal carcinoma cell lines in culture (PMID: 35165399). | 35165399 |
PubMed Id | Reference Title | Details |
---|---|---|
(35165399) | PTEN loss confers sensitivity to rapalogs in clear cell renal cell carcinoma. | Full reference... |